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    Fam3a FAM3 metabolism regulating signaling molecule A [ Mus musculus (house mouse) ]

    Gene ID: 66294, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Fam3aprovided by MGI
    Official Full Name
    FAM3 metabolism regulating signaling molecule Aprovided by MGI
    Primary source
    MGI:MGI:1913544
    See related
    Ensembl:ENSMUSG00000031399 AllianceGenome:MGI:1913544
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810037C20Rik
    Summary
    Predicted to be involved in antifungal humoral response; antimicrobial humoral immune response mediated by antimicrobial peptide; and negative regulation of antifungal innate immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human FAM3A (FAM3 metabolism regulating signaling molecule A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 19.5), genital fat pad adult (RPKM 19.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X A7.3; X 38.0 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73427816..73436856, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74384210..74393274, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted readthrough transcript (NMD candidate), 44504 Neighboring gene ubiquitin-like 4A Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 3 Neighboring gene inhibitor of kappaB kinase gamma Neighboring gene STARR-seq mESC enhancer starr_47367 Neighboring gene glucose-6-phosphate dehydrogenase X-linked Neighboring gene STARR-positive B cell enhancer ABC_E11050 Neighboring gene predicted gene, 54057

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Imipramine activates FAM3A-FOXA2-CPT2 pathway to ameliorate hepatic steatosis. Liu X, et al. Metabolism, 2022 Nov. PMID 35995281
    2. VSMC-Specific Deletion of FAM3A Attenuated Ang II-Promoted Hypertension and Cardiovascular Hypertrophy. Xiang R, et al. Circ Res, 2020 Jun 5. PMID 32279581
    3. FAM3A mediates PPARγ's protection in liver ischemia-reperfusion injury by activating Akt survival pathway and repressing inflammation and oxidative stress. Chen Z, et al. Oncotarget, 2017 Jul 25. PMID 28562339, Free PMC Article
    4. FAM3A enhances adipogenesis of 3T3-L1 preadipocytes via activation of ATP-P2 receptor-Akt signaling pathway. Chi Y, et al. Oncotarget, 2017 Jul 11. PMID 28515350, Free PMC Article
    5. FAM3A maintains metabolic homeostasis by interacting with F1-ATP synthase to regulate the activity and assembly of ATP synthase. Yan H, et al. Metabolism, 2023 Feb. PMID 36470472

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FAM3A Deficiency - Induced Mitochondrial Dysfunction Underlies Post-Infarct Mortality and Heart Failure.
      Title: FAM3A Deficiency - Induced Mitochondrial Dysfunction Underlies Post-Infarct Mortality and Heart Failure.
    2. FAM3A reshapes VSMC fate specification in abdominal aortic aneurysm by regulating KLF4 ubiquitination.
      Title: FAM3A reshapes VSMC fate specification in abdominal aortic aneurysm by regulating KLF4 ubiquitination.
    3. FAM3A maintains metabolic homeostasis by interacting with F1-ATP synthase to regulate the activity and assembly of ATP synthase.
      Title: FAM3A maintains metabolic homeostasis by interacting with F1-ATP synthase to regulate the activity and assembly of ATP synthase.
    4. Intracellular ATP Signaling Contributes to FAM3A-Induced PDX1 Upregulation in Pancreatic Beta Cells.
      Title: Intracellular ATP Signaling Contributes to FAM3A-Induced PDX1 Upregulation in Pancreatic Beta Cells.
    5. VSMC-Specific Deletion of FAM3A Attenuated Ang II-Promoted Hypertension and Cardiovascular Hypertrophy.
      Title: VSMC-Specific Deletion of FAM3A Attenuated Ang II-Promoted Hypertension and Cardiovascular Hypertrophy.
    6. FAM3A attenuates IL-1beta-induced chondrocyte apoptosis through activating the pro-survival PI3K/Akt/mTOR pathway.
      Title: FAM3A protects chondrocytes against interleukin-1β-induced apoptosis through regulating PI3K/Akt/mTOR pathway.
    7. our data demonstrate that FAM3A positively regulates angiogenesis through activation of VEGFA transcription, suggesting that FAM3A may constitute a novel molecular therapeutic target for ischaemic vascular disease.
      Title: Endothelial FAM3A positively regulates post-ischaemic angiogenesis.
    8. Study identified Fam3a, a cytokine-like protein, as a major Stat3 downstream effector in muscle stem cells and demonstrated that Fam3a is required for muscle stem cell commitment and skeletal muscle development. These findings indicate that Fam3a is a Stat3-regulated secreted factor that promotes muscle stem cell oxidative metabolism and differentiation.
      Title: The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration.
    9. FAM3A protects against liver IRI by activating Akt survival pathways, repressing inflammation and attenuating oxidative stress. Moreover, the protective effects of PPARgamma agonist(s) on liver IRI are dependent on FAM3A-ATP-Akt pathway.
      Title: FAM3A mediates PPARγ's protection in liver ischemia-reperfusion injury by activating Akt survival pathway and repressing inflammation and oxidative stress.
    10. FAM3A enhances the adipogenesis of preadipocytes by activating ATP-P2 receptor-Akt pathway. Under obese condition, a decrease in FAM3A expression in adipose tissues plays important roles in the development of adipose dysfunction and type 2 diabetes.
      Title: FAM3A enhances adipogenesis of 3T3-L1 preadipocytes via activation of ATP-P2 receptor-Akt signaling pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Clone Names

    • MGC30343

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in antifungal humoral response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of antifungal innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM3A
    Names
    family with sequence similarity 3, member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313725.2 → NP_001300654.1  protein FAM3A isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL807376
      Consensus CDS
      CCDS41022.1
      UniProtKB/Swiss-Prot
      Q9D8T0
      UniProtKB/TrEMBL
      A0A158SIT7, I7HJS7
      Related
      ENSMUSP00000114748.2, ENSMUST00000122894.8
      Conserved Domains (1) summary
      cd13940
      Location:55 → 224
      ILEI_FAM3C; Interleukin-like EMT inducer

    2. NM_001379181.2 → NP_001366110.1  protein FAM3A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL807376
      UniProtKB/TrEMBL
      I7HJS7
      Conserved Domains (1) summary
      cd13940
      Location:55 → 249
      ILEI_FAM3C; Interleukin-like EMT inducer

    3. NM_001379182.2 → NP_001366111.1  protein FAM3A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL807376
      Conserved Domains (1) summary
      cd13940
      Location:14 → 183
      ILEI_FAM3C; Interleukin-like EMT inducer

    4. NM_001403517.1 → NP_001390446.1  protein FAM3A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL807376

    5. NM_001403518.1 → NP_001390447.1  protein FAM3A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL807376
      UniProtKB/TrEMBL
      I7HPY1
      Related
      ENSMUSP00000109775.2, ENSMUST00000114139.8

    6. NM_001403519.1 → NP_001390448.1  protein FAM3A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL807376

    7. NM_001403521.1 → NP_001390450.1  protein FAM3A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL807376

    8. NM_001403522.1 → NP_001390451.1  protein FAM3A isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AL807376

    9. NM_001403523.1 → NP_001390452.1  protein FAM3A isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AL807376

    10. NM_025473.5 → NP_079749.1  protein FAM3A isoform 1 precursor

      See identical proteins and their annotated locations for NP_079749.1

      Status: VALIDATED

      Source sequence(s)
      AL807376
      Consensus CDS
      CCDS41022.1
      UniProtKB/Swiss-Prot
      Q9D8T0
      UniProtKB/TrEMBL
      A0A158SIT7, I7HJS7
      Related
      ENSMUSP00000109779.4, ENSMUST00000114143.10
      Conserved Domains (1) summary
      cd13940
      Location:55 → 224
      ILEI_FAM3C; Interleukin-like EMT inducer

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      73427816..73436856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247660.4 → XP_011245962.1  protein FAM3A isoform X2

      Conserved Domains (1) summary
      cd13940
      Location:14 → 208
      ILEI_FAM3C; Interleukin-like EMT inducer
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8T0.1 GenPept UniProtKB/Swiss-Prot:Q9D8T0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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