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    Zfp185 zinc finger protein 185 [ Mus musculus (house mouse) ]

    Gene ID: 22673, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp185provided by MGI
    Official Full Name
    zinc finger protein 185provided by MGI
    Primary source
    MGI:MGI:108095
    See related
    Ensembl:ENSMUSG00000031351 AllianceGenome:MGI:108095
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P1; Znf185
    Summary
    Predicted to enable actin filament binding activity and metal ion binding activity. Predicted to be located in actin cytoskeleton; cell junction; and cytoplasm. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; lung; and trunk mesenchyme. Orthologous to human ZNF185 (zinc finger protein 185 with LIM domain). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in genital fat pad adult (RPKM 63.1), limb E14.5 (RPKM 14.5) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X A7.3; X 37.29 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72030860..72075149)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (72987252..73031543)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene centrin 2 Neighboring gene NAD(P) dependent steroid dehydrogenase-like Neighboring gene microRNA 2137 Neighboring gene STARR-seq mESC enhancer starr_47340 Neighboring gene predicted gene, 52421 Neighboring gene paraneoplastic antigen family 5 Neighboring gene paraneoplastic antigen MA3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression pattern of Zinc finger protein 185 in mouse testis and its role in regulation of testosterone secretion. You X, et al. Mol Med Rep, 2017 Aug. PMID 28627666
    2. [ZNF185 gene cloning and the localization in mouse testis]. Pan ZF, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2010 Oct. PMID 20937232
    3. Molecular cloning and characterization of a novel mouse actin-binding protein Zfp185. Wang N, et al. J Mol Histol, 2008 Jun. PMID 18239999
    4. Genomic structure of a novel LIM domain gene (ZNF185) in Xq28 and comparisons with the orthologous murine transcript. Heiss NS, et al. Genomics, 1997 Aug 1. PMID 9268636
    5. ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells. Suzuki S, et al. Commun Biol, 2023 Jan 11. PMID 36631535, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells.
      Title: ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells.
    2. ZNF185 was highly expressed in Leydig cells of the testis and involved in the secretion of testosterone and the knockdown of ZNF185 expression did not significantly affect cell cycle progression or apoptosis.
      Title: Expression pattern of Zinc finger protein 185 in mouse testis and its role in regulation of testosterone secretion.
    3. ZNF185 is the most abundant in the testes and is located in Leydig cells and sperm. Leydig cells has weak expression and in round spermatids and mature sperm it is highly expressed.
      Title: [ZNF185 gene cloning and the localization in mouse testis].
    4. These data offered evidence for the association of mouse Zfp185 with F-actin, which supports the potential role of Zfp185 in cell fundamental activity.
      Title: Molecular cloning and characterization of a novel mouse actin-binding protein Zfp185.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 185
    Names
    LIM domain protein Zfp185
    P1-A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109043.1 → NP_001102513.1  zinc finger protein 185 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AK014497, AK048188, BB648025, BB663121, BM934903, U46687
      Consensus CDS
      CCDS53091.1
      UniProtKB/TrEMBL
      A2BI37, D7EYE4
      Related
      ENSMUSP00000110193.3, ENSMUST00000114546.9
      Conserved Domains (1) summary
      smart00132
      Location:424 → 480
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3

    2. NM_009549.3 → NP_033575.3  zinc finger protein 185 isoform a

      See identical proteins and their annotated locations for NP_033575.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AK014497, AK048188, BB648025, BB663121, BM934903, U46687
      Consensus CDS
      CCDS30191.2
      UniProtKB/TrEMBL
      D7EYE4, G5E8W8
      Related
      ENSMUSP00000126066.2, ENSMUST00000164800.8
      Conserved Domains (1) summary
      smart00132
      Location:425 → 481
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      72030860..72075149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527963.5 → XP_006528026.1  zinc finger protein 185 isoform X3

      UniProtKB/TrEMBL
      D7EYE4
      Conserved Domains (1) summary
      smart00132
      Location:396 → 452
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3

    2. XM_006527962.5 → XP_006528025.1  zinc finger protein 185 isoform X2

      UniProtKB/TrEMBL
      D7EYE4
      Conserved Domains (1) summary
      smart00132
      Location:403 → 459
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3

    3. XM_006527961.5 → XP_006528024.1  zinc finger protein 185 isoform X1

      See identical proteins and their annotated locations for XP_006528024.1

      UniProtKB/TrEMBL
      D7EYE4, G5E8W8
      Conserved Domains (1) summary
      smart00132
      Location:425 → 481
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62394.1 GenPept UniProtKB/Swiss-Prot:Q62394

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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