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    Acsm5 acyl-CoA synthetase medium-chain family member 5 [ Mus musculus (house mouse) ]

    Gene ID: 272428, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Acsm5provided by MGI
    Official Full Name
    acyl-CoA synthetase medium-chain family member 5provided by MGI
    Primary source
    MGI:MGI:2444086
    See related
    Ensembl:ENSMUSG00000030972 AllianceGenome:MGI:2444086
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C730019D22; C730027J19Rik
    Summary
    Predicted to enable fatty acid ligase activity and fatty-acyl-CoA synthase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Is expressed in axial skeleton; basisphenoid bone; and thoracic segment skeleton. Orthologous to human ACSM5 (acyl-CoA synthetase medium chain family member 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 23.3) and kidney adult (RPKM 20.2) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F2; 7 63.94 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119125354..119142583)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (119526131..119543360)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene glycoprotein 2 zymogen granule membrane Neighboring gene uromodulin Neighboring gene protein disulfide isomerase-like, testis expressed Neighboring gene acyl-CoA synthetase medium-chain family member 2 Neighboring gene predicted gene, 39078

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ACSM5 inhibits ligamentum flavum hypertrophy by regulating lipid accumulation mediated by FABP4/PPAR signaling pathway.
      Title: ACSM5 inhibits ligamentum flavum hypertrophy by regulating lipid accumulation mediated by FABP4/PPAR signaling pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (5) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables butyrate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty-acyl-CoA synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables medium-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    acyl-coenzyme A synthetase ACSM5, mitochondrial
    NP_848873.1
    XP_006507967.1
    XP_006507968.1
    XP_011240127.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178758.3 → NP_848873.1  acyl-coenzyme A synthetase ACSM5, mitochondrial precursor

      See identical proteins and their annotated locations for NP_848873.1

      Status: VALIDATED

      Source sequence(s)
      BC095985
      Consensus CDS
      CCDS40106.1
      UniProtKB/Swiss-Prot
      Q8BGA8, Q8BJS0, Q8BM02, Q8BWQ8, Q8BWS7
      UniProtKB/TrEMBL
      A0A140LHR8
      Related
      ENSMUSP00000063416.2, ENSMUST00000066465.3
      Conserved Domains (2) summary
      COG0365
      Location:48 → 572
      Acs; Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]
      cl17068
      Location:48 → 576
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      119125354..119142583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507905.2 → XP_006507968.1  acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006507968.1

      Conserved Domains (1) summary
      cl17068
      Location:22 → 343
      AFD_class_I; Adenylate forming domain, Class I superfamily

    2. XM_006507904.2 → XP_006507967.1  acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006507967.1

      UniProtKB/TrEMBL
      A0A140LHR8
      Conserved Domains (1) summary
      cl17068
      Location:61 → 589
      AFD_class_I; Adenylate forming domain, Class I superfamily

    3. XM_011241825.4 → XP_011240127.1  acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_011240127.1

      Conserved Domains (1) summary
      cl17068
      Location:22 → 343
      AFD_class_I; Adenylate forming domain, Class I superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGA8.1 GenPept UniProtKB/Swiss-Prot:Q8BGA8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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