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    Slc5a11 solute carrier family 5 (sodium/glucose cotransporter), member 11 [ Mus musculus (house mouse) ]

    Gene ID: 233836, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Slc5a11provided by MGI
    Official Full Name
    solute carrier family 5 (sodium/glucose cotransporter), member 11provided by MGI
    Primary source
    MGI:MGI:1919316
    See related
    Ensembl:ENSMUSG00000030769 AllianceGenome:MGI:1919316
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kst1; RKST2; SMIT2; Slc5a10; 2010013B02Rik
    Summary
    Predicted to enable glucose:sodium symporter activity. Involved in regulation of transporter activity. Predicted to be located in membrane. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Is expressed in glans of male genital tubercle and urethra. Orthologous to human SLC5A11 (solute carrier family 5 member 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in duodenum adult (RPKM 46.1), small intestine adult (RPKM 29.5) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F3; 7 67.42 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (122813817..122873612)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (123214594..123274388)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51498 Neighboring gene trinucleotide repeat containing 6a Neighboring gene VISTA enhancer mm1484 Neighboring gene predicted gene, 39084 Neighboring gene STARR-seq mESC enhancer starr_20085 Neighboring gene STARR-positive B cell enhancer ABC_E11366 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:130281644-130281845 Neighboring gene STARR-seq mESC enhancer starr_20086 Neighboring gene STARR-seq mESC enhancer starr_20088 Neighboring gene STARR-seq mESC enhancer starr_20089 Neighboring gene STARR-seq mESC enhancer starr_20090 Neighboring gene Rho GTPase activating protein 17 Neighboring gene STARR-positive B cell enhancer ABC_E4974 Neighboring gene STARR-seq mESC enhancer starr_20097 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:130521438-130521621 Neighboring gene leucine carboxyl methyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sodium/myo-Inositol transporters: substrate transport requirements and regional brain expression in the TgCRND8 mouse model of amyloid pathology. Fenili D, et al. PLoS One, 2011. PMID 21887366, Free PMC Article
    2. Contributions in astrocytes of SMIT1/2 and HMIT to myo-inositol uptake at different concentrations and pH. Fu H, et al. Neurochem Int, 2012 Jul. PMID 22564531
    3. Identification of a novel Na+/myo-inositol cotransporter. Coady MJ, et al. J Biol Chem, 2002 Sep 20. PMID 12133831
    4. KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability. Abbott GW, et al. Sci Signal, 2014 Mar 4. PMID 24595108, Free PMC Article
    5. Characterization of the null murine sodium/myo-inositol cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is independent of expression of its cognate mitochondrial ribosomal protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels in neonatal brain. Buccafusca R, et al. Mol Genet Metab, 2008 Sep-Oct. PMID 18675571

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. At low concentration, where SMIT1/2 activity gains importance, myo-inositol uptake is reduced by ammonia-induced intracellular acidification
      Title: Contributions in astrocytes of SMIT1/2 and HMIT to myo-inositol uptake at different concentrations and pH.
    2. For SMIT2, at all three ages both cortical and cerebellar SMIT2 levels were significantly higher than hippocampal levels (p<0.05) and at 4 and 6 months of age
      Title: Sodium/myo-Inositol transporters: substrate transport requirements and regional brain expression in the TgCRND8 mouse model of amyloid pathology.
    3. Rabbit homologue acts as a low affinity Na/myo-inositol cotransporter.
      Title: Identification of a novel Na+/myo-inositol cotransporter.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC25910

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glucose:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myo-inositol transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in myo-inositol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium/myo-inositol cotransporter 2
    Names
    Na(+)/myo-inositol cotransporter 2
    na+/myo-inositol cotransporter 2
    sodium-coupled cotransporter KST1
    sodium-dependent glucose cotransporter
    sodium/glucose cotransporter KST1
    sodium/myo-inositol transporter 2
    solute carrier family 5 (sodium/glucose cotransporter), member 10
    solute carrier family 5 member 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146198.2 → NP_666310.1  sodium/myo-inositol cotransporter 2

      See identical proteins and their annotated locations for NP_666310.1

      Status: PROVISIONAL

      Source sequence(s)
      AC138364
      Consensus CDS
      CCDS21819.1
      UniProtKB/Swiss-Prot
      Q6EZ51, Q8K0E3
      Related
      ENSMUSP00000033035.7, ENSMUST00000033035.13
      Conserved Domains (1) summary
      cl00456
      Location:28 → 673
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      122813817..122873612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241767.4 → XP_011240069.1  sodium/myo-inositol cotransporter 2 isoform X1

      See identical proteins and their annotated locations for XP_011240069.1

      UniProtKB/Swiss-Prot
      Q6EZ51, Q8K0E3
      Conserved Domains (1) summary
      cl00456
      Location:28 → 673
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. XM_011241766.3 → XP_011240068.1  sodium/myo-inositol cotransporter 2 isoform X1

      See identical proteins and their annotated locations for XP_011240068.1

      UniProtKB/Swiss-Prot
      Q6EZ51, Q8K0E3
      Conserved Domains (1) summary
      cl00456
      Location:28 → 673
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. XM_011241768.3 → XP_011240070.1  sodium/myo-inositol cotransporter 2 isoform X1

      See identical proteins and their annotated locations for XP_011240070.1

      UniProtKB/Swiss-Prot
      Q6EZ51, Q8K0E3
      Conserved Domains (1) summary
      cl00456
      Location:28 → 673
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. XM_006507712.4 → XP_006507775.1  sodium/myo-inositol cotransporter 2 isoform X1

      See identical proteins and their annotated locations for XP_006507775.1

      UniProtKB/Swiss-Prot
      Q6EZ51, Q8K0E3
      Related
      ENSMUSP00000127977.3, ENSMUST00000167299.9
      Conserved Domains (1) summary
      cl00456
      Location:28 → 673
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    5. XM_011241769.1 → XP_011240071.1  sodium/myo-inositol cotransporter 2 isoform X2

      Conserved Domains (1) summary
      cl00456
      Location:2 → 570
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RNA

    1. XR_001785540.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K0E3.1 GenPept UniProtKB/Swiss-Prot:Q8K0E3

    Gene LinkOut

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