Hapln3 hyaluronan and proteoglycan link protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hapln3provided by MGI
Official Full Name: hyaluronan and proteoglycan link protein 3provided by MGI
Primary source: MGI:MGI:1914916
See related: Ensembl:ENSMUSG00000030606 AllianceGenome:MGI:1914916
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lpr3; 4930554N11Rik
Summary: Predicted to enable hyaluronic acid binding activity. Predicted to be involved in central nervous system development and skeletal system development. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Orthologous to human HAPLN3 (hyaluronan and proteoglycan link protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in placenta adult (RPKM 1.7), genital fat pad adult (RPKM 1.7) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D2; 7 44.9 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (78766775..78783100, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (79117027..79133173, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hyaluronic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in glial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuroblast proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal system development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in perineuronal net	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hyaluronan and proteoglycan link protein 3

Names: link protein 3

NP_839986.2

EC 3.1.2.15

XP_006541190.1

EC 3.1.2.15

XP_006541191.1

EC 3.1.2.15

XP_036009276.1

EC 3.1.2.15

XP_036009277.1

EC 3.1.2.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178255.3 → NP_839986.2 hyaluronan and proteoglycan link protein 3 precursor

See identical proteins and their annotated locations for NP_839986.2

Status: PROVISIONAL

Source sequence(s)

AY262757

Consensus CDS

CCDS21378.1

UniProtKB/Swiss-Prot

Q3UVT2, Q80WM5, Q80XX3

UniProtKB/TrEMBL

Q2NLE4

Related

ENSMUSP00000146090.2, ENSMUST00000206092.2

Conserved Domains (3) summary

cd03518
Location:166 → 260

Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...

cd03519
Location:267 → 356

Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...

cd05877
Location:52 → 168

Ig_LP_like; Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

78766775..78783100 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006541128.5 → XP_006541191.1 hyaluronan and proteoglycan link protein 3 isoform X2

See identical proteins and their annotated locations for XP_006541191.1

UniProtKB/Swiss-Prot

Q3UVT2, Q80WM5, Q80XX3

UniProtKB/TrEMBL

Q2NLE4

Conserved Domains (3) summary

cd03518
Location:166 → 260

Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...

cd03519
Location:267 → 356

Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...

cd05877
Location:52 → 168

Ig_LP_like; Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains
XM_006541127.5 → XP_006541190.1 hyaluronan and proteoglycan link protein 3 isoform X2

See identical proteins and their annotated locations for XP_006541190.1

UniProtKB/Swiss-Prot

Q3UVT2, Q80WM5, Q80XX3

UniProtKB/TrEMBL

Q2NLE4

Conserved Domains (3) summary

cd03518
Location:166 → 260

Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...

cd03519
Location:267 → 356

Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...

cd05877
Location:52 → 168

Ig_LP_like; Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains
XM_036153384.1 → XP_036009277.1 hyaluronan and proteoglycan link protein 3 isoform X2

UniProtKB/Swiss-Prot

Q3UVT2, Q80WM5, Q80XX3

UniProtKB/TrEMBL

Q2NLE4

Conserved Domains (3) summary

cd03518
Location:166 → 260

Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...

cd03519
Location:267 → 356

Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...

cd05877
Location:52 → 168

Ig_LP_like; Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains
XM_036153383.1 → XP_036009276.1 hyaluronan and proteoglycan link protein 3 isoform X1

UniProtKB/TrEMBL

Q2NLE4

Conserved Domains (3) summary

cd03518
Location:189 → 283

Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...

cd03519
Location:290 → 379

Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...

cd05877
Location:75 → 191

Ig_LP_like; Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains