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    Strn4 striatin, calmodulin binding protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 97387, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Strn4provided by MGI
    Official Full Name
    striatin, calmodulin binding protein 4provided by MGI
    Primary source
    MGI:MGI:2142346
    See related
    Ensembl:ENSMUSG00000030374 AllianceGenome:MGI:2142346
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZIN; zinedin
    Summary
    Predicted to enable armadillo repeat domain binding activity; calmodulin binding activity; and protein phosphatase 2A binding activity. Predicted to be located in dendritic spine. Predicted to be part of FAR/SIN/STRIPAK complex. Predicted to be active in dendrite. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and musculoskeletal system. Orthologous to human STRN4 (striatin 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 50.8), CNS E18 (RPKM 43.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A2; 7 9.15 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (16549814..16574856)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16815889..16840931)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4899 Neighboring gene STARR-positive B cell enhancer ABC_E6517 Neighboring gene adaptor-related protein complex 2, sigma 1 subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:17351790-17352086 Neighboring gene STARR-positive B cell enhancer ABC_E694 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:17368547-17368700 Neighboring gene solute carrier family 1 (neutral amino acid transporter), member 5 Neighboring gene fukutin related protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:17426612-17426765 Neighboring gene STARR-positive B cell enhancer ABC_E9686 Neighboring gene STARR-positive B cell enhancer ABC_E4900 Neighboring gene protein kinase D2 Neighboring gene RIKEN cDNA 9330104G04 gene Neighboring gene STARR-positive B cell enhancer ABC_E3701

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain. Castets F, et al. J Biol Chem, 2000 Jun 30. PMID 10748158
    2. Functional consequences of necdin nucleocytoplasmic localization. Lavi-Itzkovitz A, et al. PLoS One, 2012. PMID 22442722, Free PMC Article
    3. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
    4. Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747
    5. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables armadillo repeat domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables armadillo repeat domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase 2A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    striatin-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039878.2 → NP_001034967.1  striatin-4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal 7-aa segment, compared to isoform 1.
      Source sequence(s)
      AC148981, AK136155, BC066805
      Consensus CDS
      CCDS39787.1
      UniProtKB/TrEMBL
      Q3U3S0
      Related
      ENSMUSP00000104135.2, ENSMUST00000108495.9
      Conserved Domains (4) summary
      COG2319
      Location:416 → 746
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:430 → 752
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08232
      Location:64 → 189
      Striatin; Striatin family
      sd00039
      Location:443 → 489
      7WD40; WD40 repeat [structural motif]

    2. NM_133789.3 → NP_598550.2  striatin-4 isoform 1

      See identical proteins and their annotated locations for NP_598550.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC148981, BC066805, BC080283
      Consensus CDS
      CCDS39786.1
      UniProtKB/Swiss-Prot
      E9QKX6, P58404, Q68EF5
      UniProtKB/TrEMBL
      Q3U3S0
      Related
      ENSMUSP00000019220.9, ENSMUST00000019220.16
      Conserved Domains (4) summary
      COG2319
      Location:423 → 753
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:437 → 759
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08232
      Location:64 → 189
      Striatin; Striatin family
      sd00039
      Location:450 → 496
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      16549814..16574856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312409.2 → XP_017167898.1  striatin-4 isoform X3

      Conserved Domains (1) summary
      pfam08232
      Location:64 → 189
      Striatin; Striatin family

    2. XM_036153606.1 → XP_036009499.1  striatin-4 isoform X4

      Conserved Domains (1) summary
      pfam08232
      Location:65 → 189
      Striatin; Striatin family

    3. XM_006540446.3 → XP_006540509.1  striatin-4 isoform X1

      UniProtKB/TrEMBL
      Q3U3S0
      Conserved Domains (3) summary
      cd00200
      Location:318 → 640
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:331 → 377
      7WD40; WD40 repeat [structural motif]
      pfam08232
      Location:1 → 70
      Striatin; Striatin family

    4. XM_017312408.2 → XP_017167897.1  striatin-4 isoform X2

      UniProtKB/TrEMBL
      Q3U3S0
      Conserved Domains (3) summary
      cd00200
      Location:311 → 633
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:324 → 370
      7WD40; WD40 repeat [structural motif]
      pfam08232
      Location:1 → 70
      Striatin; Striatin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58404.2 GenPept UniProtKB/Swiss-Prot:P58404

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