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    Atf7ip activating transcription factor 7 interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 54343, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Atf7ipprovided by MGI
    Official Full Name
    activating transcription factor 7 interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1858965
    See related
    Ensembl:ENSMUSG00000030213 AllianceGenome:MGI:1858965
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AM; Mcaf1; 2610204M12Rik; 5830415B17Rik
    Summary
    Enables ATP hydrolysis activity and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; male reproductive gland or organ; and sensory organ. Orthologous to human ATF7IP (activating transcription factor 7 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 11.1), whole brain E14.5 (RPKM 7.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6; 6 G1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (136495787..136587848)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (136518789..136610850)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:136440301-136440484 Neighboring gene ribosomal protein L36A, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_17596 Neighboring gene predicted gene, 44140 Neighboring gene coenzyme Q2 homolog, prenyltransferase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E691 Neighboring gene STARR-positive B cell enhancer ABC_E9106 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:136480481-136480679 Neighboring gene STARR-seq mESC enhancer starr_17599 Neighboring gene STARR-positive B cell enhancer ABC_E9282 Neighboring gene STARR-positive B cell enhancer ABC_E1715 Neighboring gene STARR-positive B cell enhancer ABC_E10415 Neighboring gene STARR-seq mESC enhancer starr_17605 Neighboring gene phospholipase B domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E4875 Neighboring gene predicted gene, 40409 Neighboring gene protein S100-A10 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8(+) T Cell Effector and Memory Responses. Sin JH, et al. J Immunol, 2022 Mar 1. PMID 35110421, Free PMC Article
    2. The fibronectin type-III (FNIII) domain of ATF7IP contributes to efficient transcriptional silencing mediated by the SETDB1 complex. Tsusaka T, et al. Epigenetics Chromatin, 2020 Nov 30. PMID 33256805, Free PMC Article
    3. Atf7ip Inhibits Osteoblast Differentiation via Negative Regulation of the Sp7 Transcription Factor. Hu G, et al. Int J Mol Sci, 2023 Feb 21. PMID 36901736, Free PMC Article
    4. The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses. Sin JH, et al. J Exp Med, 2019 Sep 2. PMID 31217192, Free PMC Article
    5. Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation. Uchimura Y, et al. J Biol Chem, 2006 Aug 11. PMID 16757475

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Atf7ip Inhibits Osteoblast Differentiation via Negative Regulation of the Sp7 Transcription Factor.
      Title: Atf7ip Inhibits Osteoblast Differentiation via Negative Regulation of the Sp7 Transcription Factor.
    2. ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8(+) T Cell Effector and Memory Responses.
      Title: ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8(+) T Cell Effector and Memory Responses.
    3. The fibronectin type-III (FNIII) domain of ATF7IP contributes to efficient transcriptional silencing mediated by the SETDB1 complex.
      Title: The fibronectin type-III (FNIII) domain of ATF7IP contributes to efficient transcriptional silencing mediated by the SETDB1 complex.
    4. ATF7ip is an inhibitor of Il2 gene expression
      Title: The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses.
    5. We demonstrated the importance of Aire's interaction with the ATF7ip-MBD1 protein complex in maintaining central tolerance
      Title: The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.
    6. mAM/hAM facilitates conversion of H3-K9 dimethyl to trimethyl by ESET/SETDB1
      Title: mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (5) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA methylation-dependent heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA methylation-dependent heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    activating transcription factor 7-interacting protein 1
    Names
    ATFa-associated Modulator
    MBD1-containing chromatin-associated factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001388194.1 → NP_001375123.1  activating transcription factor 7-interacting protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124779, AC134474
      Conserved Domains (5) summary
      PHA03247
      Location:869 → 1213
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83 → 362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290 → 626
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:601 → 812
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:1199 → 1299
      fn3_4; Fibronectin-III type domain

    2. NM_001388195.1 → NP_001375124.1  activating transcription factor 7-interacting protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124779, AC134474
      Conserved Domains (5) summary
      PHA03247
      Location:868 → 1212
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83 → 362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290 → 623
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:598 → 811
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:1198 → 1298
      fn3_4; Fibronectin-III type domain

    3. NM_001388196.1 → NP_001375125.1  activating transcription factor 7-interacting protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC124779, AC134474
      Conserved Domains (5) summary
      PHA03247
      Location:866 → 1208
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83 → 362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290 → 623
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:598 → 809
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:1194 → 1294
      fn3_4; Fibronectin-III type domain

    4. NM_001388197.1 → NP_001375126.1  activating transcription factor 7-interacting protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC124779, AC134474
      Conserved Domains (3) summary
      PHA03247
      Location:271 → 615
      PHA03247; large tegument protein UL36; Provisional
      pfam16788
      Location:3 → 214
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:601 → 701
      fn3_4; Fibronectin-III type domain

    5. NM_019426.3 → NP_062299.2  activating transcription factor 7-interacting protein 1 isoform 3

      See identical proteins and their annotated locations for NP_062299.2

      Status: VALIDATED

      Source sequence(s)
      AC124779, AC134474
      Consensus CDS
      CCDS20651.1
      UniProtKB/Swiss-Prot
      Q3TJ86, Q3TZW1, Q3UVK5, Q3UYZ7, Q7TT18, Q80ZK7, Q8C4A1, Q9JK31
      Related
      ENSMUSP00000032335.7, ENSMUST00000032335.13
      Conserved Domains (5) summary
      PHA03247
      Location:866 → 1210
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83 → 362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290 → 623
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:598 → 809
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:1196 → 1296
      fn3_4; Fibronectin-III type domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      136495787..136587848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166296.1 → XP_036022189.1  activating transcription factor 7-interacting protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3TJ86, Q3TZW1, Q3UVK5, Q3UYZ7, Q7TT18, Q80ZK7, Q8C4A1, Q9JK31
      Conserved Domains (5) summary
      PHA03247
      Location:866 → 1210
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83 → 362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290 → 623
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:598 → 809
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:1196 → 1296
      fn3_4; Fibronectin-III type domain

    2. XM_036166295.1 → XP_036022188.1  activating transcription factor 7-interacting protein 1 isoform X1

      Conserved Domains (5) summary
      PHA03247
      Location:869 → 1213
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83 → 362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290 → 626
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:601 → 812
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:1199 → 1299
      fn3_4; Fibronectin-III type domain

    3. XM_017321681.3 → XP_017177170.1  activating transcription factor 7-interacting protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3TJ86, Q3TZW1, Q3UVK5, Q3UYZ7, Q7TT18, Q80ZK7, Q8C4A1, Q9JK31
      Conserved Domains (5) summary
      PHA03247
      Location:866 → 1210
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83 → 362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290 → 623
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:598 → 809
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:1196 → 1296
      fn3_4; Fibronectin-III type domain

    4. XM_006506390.5 → XP_006506453.1  activating transcription factor 7-interacting protein 1 isoform X3

      Conserved Domains (5) summary
      PHA03247
      Location:877 → 1221
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:91 → 370
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:298 → 634
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:609 → 820
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:1207 → 1307
      fn3_4; Fibronectin-III type domain

    5. XM_030255502.2 → XP_030111362.1  activating transcription factor 7-interacting protein 1 isoform X4

      Conserved Domains (5) summary
      PHA03247
      Location:874 → 1218
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:91 → 370
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:298 → 631
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:606 → 817
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:1204 → 1304
      fn3_4; Fibronectin-III type domain

    6. XM_006506388.5 → XP_006506451.2  activating transcription factor 7-interacting protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006506451.2

      Conserved Domains (5) summary
      PHA03247
      Location:869 → 1213
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83 → 362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290 → 626
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:601 → 812
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:1199 → 1299
      fn3_4; Fibronectin-III type domain

    7. XM_006506389.5 → XP_006506452.2  activating transcription factor 7-interacting protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006506452.2

      UniProtKB/Swiss-Prot
      Q3TJ86, Q3TZW1, Q3UVK5, Q3UYZ7, Q7TT18, Q80ZK7, Q8C4A1, Q9JK31
      Conserved Domains (5) summary
      PHA03247
      Location:866 → 1210
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83 → 362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290 → 623
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:598 → 809
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:1196 → 1296
      fn3_4; Fibronectin-III type domain

    8. XM_036166294.1 → XP_036022187.1  activating transcription factor 7-interacting protein 1 isoform X1

      Conserved Domains (5) summary
      PHA03247
      Location:869 → 1213
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83 → 362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290 → 626
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:601 → 812
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:1199 → 1299
      fn3_4; Fibronectin-III type domain

    9. XM_030255503.2 → XP_030111363.1  activating transcription factor 7-interacting protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3TJ86, Q3TZW1, Q3UVK5, Q3UYZ7, Q7TT18, Q80ZK7, Q8C4A1, Q9JK31
      Conserved Domains (5) summary
      PHA03247
      Location:866 → 1210
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83 → 362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290 → 623
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:598 → 809
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:1196 → 1296
      fn3_4; Fibronectin-III type domain

    10. XM_006506392.3 → XP_006506455.1  activating transcription factor 7-interacting protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006506455.1

      Conserved Domains (5) summary
      PHA03247
      Location:869 → 1213
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:83 → 362
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5271
      Location:290 → 626
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam16788
      Location:601 → 812
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:1199 → 1299
      fn3_4; Fibronectin-III type domain

    RNA

    1. XR_004942987.1 RNA Sequence

    2. XR_004942986.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TT18.1 GenPept UniProtKB/Swiss-Prot:Q7TT18

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