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    Klrg1 killer cell lectin-like receptor subfamily G, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 50928, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Klrg1provided by MGI
    Official Full Name
    killer cell lectin-like receptor subfamily G, member 1provided by MGI
    Primary source
    MGI:MGI:1355294
    See related
    Ensembl:ENSMUSG00000030114 AllianceGenome:MGI:1355294
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MAFA; 2F1-Ag; MAFA-L
    Summary
    Predicted to enable carbohydrate binding activity. Predicted to act upstream of or within cell surface receptor signaling pathway. Predicted to be located in intracellular membrane-bounded organelle. Orthologous to human KLRG1 (killer cell lectin like receptor G1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 F1; 6 57.52 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (122247555..122259792, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (122270596..122282833, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene murinoglobulin pseudogene Neighboring gene murinoglobulin, pseudogene 1 Neighboring gene predicted gene, 46974 Neighboring gene STARR-positive B cell enhancer ABC_E6483 Neighboring gene predicted gene, 53340 Neighboring gene predicted gene 6637

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers. Tata A, et al. Oncoimmunology, 2021 Jun 15. PMID 34188973, Free PMC Article
    2. Antigen Nonspecific Induction of Distinct Regulatory T Cell States in Oncogene-Driven Hyperproliferative Skin. Zhou C, et al. Immunohorizons, 2021 Feb 22. PMID 33619159
    3. KLRG1 impairs regulatory T-cell competitive fitness in the gut. Meinicke H, et al. Immunology, 2017 Sep. PMID 28437578, Free PMC Article
    4. Murine autoimmune cholangitis requires two hits: cytotoxic KLRG1(+) CD8 effector cells and defective T regulatory cells. Huang W, et al. J Autoimmun, 2014 May. PMID 24556277, Free PMC Article
    5. Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmune encephalomyelitis. Tauro S, et al. Eur J Immunol, 2013 May. PMID 23436224, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Antigen Nonspecific Induction of Distinct Regulatory T Cell States in Oncogene-Driven Hyperproliferative Skin.
      Title: Antigen Nonspecific Induction of Distinct Regulatory T Cell States in Oncogene-Driven Hyperproliferative Skin.
    2. Single-Cell Sequencing Reveals the Novel Role of Ezh2 in NK Cell Maturation and Function.
      Title: Single-Cell Sequencing Reveals the Novel Role of Ezh2 in NK Cell Maturation and Function.
    3. Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8+ T cells in skin.
      Title: Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8+ T cells in skin.
    4. KLRG1(+) Memory CD8 T Cells Combine Properties of Short-Lived Effectors and Long-Lived Memory.
      Title: KLRG1(+) Memory CD8 T Cells Combine Properties of Short-Lived Effectors and Long-Lived Memory.
    5. This paper demonstrates that developmental plasticity of KLRG1(+) effector CD8(+) T cells is important in promoting functionally versatile memory cells and long-term protective immunity.
      Title: KLRG1(+) Effector CD8(+) T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.
    6. KLRG1 expression identifies short-lived Foxp3(+) Treg effector cells with functional plasticity in islets of NOD mice.
      Title: KLRG1 expression identifies short-lived Foxp3(+) T(reg) effector cells with functional plasticity in islets of NOD mice.
    7. Although absence of KLRG1 is not enough to increase intestinal Treg cells in KLRG1 knockout mice, KLRG1 ligation reduces T-cell receptor signals and the competitive fitness of individual Treg cells in the intestine.
      Title: KLRG1 impairs regulatory T-cell competitive fitness in the gut.
    8. Treg cell accumulation in intestinal tumours from APC(min/+) mice was exclusively due to the increase in KLRG1(+) GATA3(+) Treg cells.
      Title: Tumour-associated changes in intestinal epithelial cells cause local accumulation of KLRG1(+) GATA3(+) regulatory T cells in mice.
    9. Ly6C, 4-1BB, and KLRG1 have roles in the activation of lamina propria lymphocytes in the small intestine in a mouse model of Crohn's disease
      Title: Involvement of Ly6C, 4-1BB, and KLRG1 in the activation of lamina propria lymphocytes in the small intestine of sanroque mice.
    10. This finding provides a rationale for the reciprocal expression of KLRG1 and CD103 in different CD8(+) T-cell subsets.
      Title: TGF-β downregulates KLRG1 expression in mouse and human CD8(+) T cells.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123930

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    killer cell lectin-like receptor subfamily G member 1
    Names
    mast cell function-associated antigen 2F1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016970.1 → NP_058666.1  killer cell lectin-like receptor subfamily G member 1

      See identical proteins and their annotated locations for NP_058666.1

      Status: PROVISIONAL

      Source sequence(s)
      AF097357
      Consensus CDS
      CCDS20492.1
      UniProtKB/Swiss-Prot
      O88713, Q3T1F0
      Related
      ENSMUSP00000032207.9, ENSMUST00000032207.9
      Conserved Domains (1) summary
      cd03593
      Location:75 → 185
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      122247555..122259792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88713.2 GenPept UniProtKB/Swiss-Prot:O88713

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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