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    Fbxl14 F-box and leucine-rich repeat protein 14 [ Mus musculus (house mouse) ]

    Gene ID: 101358, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fbxl14provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 14provided by MGI
    Primary source
    MGI:MGI:2141676
    See related
    Ensembl:ENSMUSG00000030019 AllianceGenome:MGI:2141676
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbx14l
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL14 (F-box and leucine rich repeat protein 14). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human all
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    Genomic context

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    Location:
    6 F1; 6 56.86 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (119456629..119460847)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (119479668..119483886)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene adiponectin receptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E9099 Neighboring gene STARR-seq mESC enhancer starr_17147 Neighboring gene STARR-seq mESC enhancer starr_17149 Neighboring gene wingless-type MMTV integration site family, member 5B Neighboring gene predicted gene, 40397 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:119472087-119472240 Neighboring gene predicted gene, 30690 Neighboring gene predicted gene, 52875

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The E3 ubiquitin ligase SCF(FBXL14) complex stimulates neuronal differentiation by targeting the Notch signaling factor HES1 for proteolysis. Chen F, et al. J Biol Chem, 2017 Dec 8. PMID 29070679, Free PMC Article
    2. The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation. Viñas-Castells R, et al. J Biol Chem, 2010 Feb 5. PMID 19955572, Free PMC Article
    3. A conserved F-box gene with unusual transcript localization. Das T, et al. Dev Genes Evol, 2002 Apr. PMID 11976951
    4. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest that SCF(FBXL14) promotes neuronal differentiation by targeting HES1 for ubiquitin-dependent proteolysis and that the C-terminal WRPW motif in HES1 is required for this process
      Title: The E3 ubiquitin ligase SCF(FBXL14) complex stimulates neuronal differentiation by targeting the Notch signaling factor HES1 for proteolysis.
    2. Data show that Twist1 small interfering RNA prevents hypoxia-induced Fbxl14 down-regulation and SNAIL1 stabilization.
      Title: The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133940.3 → NP_598701.2  F-box/LRR-repeat protein 14

      See identical proteins and their annotated locations for NP_598701.2

      Status: VALIDATED

      Source sequence(s)
      AC126607
      Consensus CDS
      CCDS20475.1
      UniProtKB/Swiss-Prot
      Q3U2Q9, Q8BID8, Q8R5H7, Q8VDT7, Q922N5
      Related
      ENSMUSP00000032094.6, ENSMUST00000032094.7
      Conserved Domains (3) summary
      cd09293
      Location:228 → 395
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:145 → 170
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:5 → 46
      F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      119456629..119460847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BID8.1 GenPept UniProtKB/Swiss-Prot:Q8BID8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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