Epha1 Eph receptor A1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Epha1provided by MGI
Official Full Name: Eph receptor A1provided by MGI
Primary source: MGI:MGI:107381
See related: Ensembl:ENSMUSG00000029859 AllianceGenome:MGI:107381
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Eph; Esk; 5730453L17Rik
Summary: Enables ephrin receptor activity. Involved in positive regulation of stress fiber assembly. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; genitourinary system; and unsegmented mesenchyme. Orthologous to human EPHA1 (EPH receptor A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in duodenum adult (RPKM 22.5), small intestine adult (RPKM 20.3) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B2.1; 6 20.65 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (42335421..42350249, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (42358487..42373314, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EphA1 aggravates neuropathic pain by activating CXCR4/RhoA/ROCK2 pathway in mice.
Title: EphA1 aggravates neuropathic pain by activating CXCR4/RhoA/ROCK2 pathway in mice.
EphA1 receptor tyrosine kinase is localized to the nucleus in rhabdomyosarcoma from multiple species.
Title: EphA1 receptor tyrosine kinase is localized to the nucleus in rhabdomyosarcoma from multiple species.
EphA1 Activation Induces Neuropathological Changes in a Mouse Model of Parkinson's Disease Through the CXCL12/CXCR4 Signaling Pathway.
Title: EphA1 Activation Induces Neuropathological Changes in a Mouse Model of Parkinson's Disease Through the CXCL12/CXCR4 Signaling Pathway.
Activation of EphA1-Epha receptor axis attenuates diabetic nephropathy in mice.
Title: Activation of EphA1-Epha receptor axis attenuates diabetic nephropathy in mice.
These findings suggest that the ternary complex of EphA, FGFR and FRS2alpha formed by ligand stimulation regulates self-renewal and differentiation of mouse embryonic neural stem/progenitor cells
Title: Trans-Activation between EphA and FGFR Regulates Self-Renewal and Differentiation of Mouse Embryonic Neural Stem/Progenitor Cells via Differential Activation of FRS2α.
These results highlight the complex role of Eph:ephrin signaling in the development of the sensory-motor circuit innervating the limb.
Title: Eph:ephrin-B1 forward signaling controls fasciculation of sensory and motor axons.
Whole-mount in situ hybridization revealed overlapping expression of the Epha1 receptor and its high-affinity ligands ephrin A1 (Efna1) and ephrin A3 (Efna3) in the primitive streak and the posterior paraxial mesoderm during early mouse development.
Title: Expression analysis of the Epha1 receptor tyrosine kinase and its high-affinity ligands Efna1 and Efna3 during early mouse development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Epha1 (e-PCR), detects polymorphism
- UniSTS:506882

RH124207 (e-PCR)
- UniSTS:161029

UniSTS:495879 (e-PCR)
- UniSTS:495879

Epha1 (e-PCR), detects polymorphism
- UniSTS:495879

NoName (e-PCR)
- UniSTS:548477

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ephrin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane-ephrin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of stress fiber assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ephrin type-A receptor 1

Names: embryonic stem cell kinase; mEpha1; tyrosine-protein kinase receptor ESK

NP_076069.2

EC 2.7.10.1

XP_011239505.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023580.4 → NP_076069.2 ephrin type-A receptor 1 precursor

See identical proteins and their annotated locations for NP_076069.2

Status: PROVISIONAL

Source sequence(s)

AC153915

Consensus CDS

CCDS20067.1

UniProtKB/Swiss-Prot

Q60750, Q8CED9, Q9ESJ2

UniProtKB/TrEMBL

Q6IR19

Related

ENSMUSP00000073099.3, ENSMUST00000073387.5

Conserved Domains (8) summary

cd09542
Location:913 → 975

SAM_EPH-A1; SAM domain of EPH-A1 subfamily of tyrosine kinase receptors

smart00454
Location:912 → 977

SAM; Sterile alpha motif

cd10479
Location:28 → 204

EphR_LBD_A1; Ligand Binding Domain of Ephrin type-A Receptor 1

cd00063
Location:454 → 536

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:335 → 426

fn3; Fibronectin type III domain

pfam07714
Location:625 → 881

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:597 → 620

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl21453
Location:620 → 885

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

42335421..42350249 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241203.4 → XP_011239505.1 ephrin type-A receptor 1 isoform X1

Conserved Domains (6) summary

cd10479
Location:28 → 204

EphR_LBD_A1; Ligand Binding Domain of Ephrin type-A Receptor 1

cd12841
Location:537 → 554

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

cd00063
Location:454 → 536

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00185
Location:281 → 312

TNFRSF; CRD2 [structural motif]

pfam00041
Location:335 → 426

fn3; Fibronectin type III domain

cl22855
Location:252 → 320

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)