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    Wnt16 wingless-type MMTV integration site family, member 16 [ Mus musculus (house mouse) ]

    Gene ID: 93735, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Wnt16provided by MGI
    Official Full Name
    wingless-type MMTV integration site family, member 16provided by MGI
    Primary source
    MGI:MGI:2136018
    See related
    Ensembl:ENSMUSG00000029671 AllianceGenome:MGI:2136018
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E130309I19Rik
    Summary
    Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within bone remodeling and cardiac epithelial to mesenchymal transition. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; heart; and limb. Orthologous to human WNT16 (Wnt family member 16). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in ovary adult (RPKM 2.9), subcutaneous fat pad adult (RPKM 1.0) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 A3.1; 6 9.22 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (22288179..22298521)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (22288178..22298522)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene cadherin-like and PC-esterase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_15308 Neighboring gene 60S ribosomal protein L32 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15309 Neighboring gene predicted gene 42573 Neighboring gene STARR-seq mESC enhancer starr_15310 Neighboring gene FAM3 metabolism regulating signaling molecule C Neighboring gene STARR-seq mESC enhancer starr_15315 Neighboring gene predicted gene, 38773

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Induced inactivation of Wnt16 in young adult mice has no impact on osteoarthritis development. Törnqvist AE, et al. PLoS One, 2022. PMID 36367882, Free PMC Article
    2. WNT16 is upregulated early in mouse TMJ osteoarthritis and protects fibrochondrocytes against IL-1β induced inflammatory response by regulation of RUNX2/MMP13 cascade. Liu X, et al. Bone, 2021 Feb. PMID 33301961
    3. Wnt16 Overexpression in Osteoblasts Increases the Subchondral Bone Mass but has no Impact on Osteoarthritis in Young Adult Female Mice. Törnqvist AE, et al. Calcif Tissue Int, 2020 Jul. PMID 32140758, Free PMC Article
    4. Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo. Hildebrandt S, et al. Sci Rep, 2018 Jun 7. PMID 29880826, Free PMC Article
    5. Inducible Wnt16 inactivation: WNT16 regulates cortical bone thickness in adult mice. Ohlsson C, et al. J Endocrinol, 2018 May. PMID 29530924, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz (Wwtr1) Activation in Male LDLR-/- Mice.
      Title: Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz (Wwtr1) Activation in Male LDLR-/- Mice.
    2. WNT16b promotes the proliferation and self-renewal of human limbal epithelial stem/progenitor cells via activating the calcium/calcineurin A/NFATC2 pathway.
      Title: WNT16b promotes the proliferation and self-renewal of human limbal epithelial stem/progenitor cells via activating the calcium/calcineurin A/NFATC2 pathway.
    3. Induced inactivation of Wnt16 in young adult mice has no impact on osteoarthritis development.
      Title: Induced inactivation of Wnt16 in young adult mice has no impact on osteoarthritis development.
    4. WNT16B enhances the proliferation and self-renewal of limbal epithelial cells via CXCR4/MEK/ERK signaling.
      Title: WNT16B enhances the proliferation and self-renewal of limbal epithelial cells via CXCR4/MEK/ERK signaling.
    5. WNT16 is upregulated early in mouse TMJ osteoarthritis and protects fibrochondrocytes against IL-1beta induced inflammatory response by regulation of RUNX2/MMP13 cascade.
      Title: WNT16 is upregulated early in mouse TMJ osteoarthritis and protects fibrochondrocytes against IL-1β induced inflammatory response by regulation of RUNX2/MMP13 cascade.
    6. Wnt16 Overexpression in Osteoblasts Increases the Subchondral Bone Mass but has no Impact on Osteoarthritis in Young Adult Female Mice.
      Title: Wnt16 Overexpression in Osteoblasts Increases the Subchondral Bone Mass but has no Impact on Osteoarthritis in Young Adult Female Mice.
    7. Lower WNT16 expression in patients with adolescent idiopathic scoliosis - potential link to lower bone mass in AIS?
      Title: Lower WNT16 expression in patients with adolescent idiopathic scoliosis - potential link to lower bone mass in AIS?
    8. GC treatment with dexamethasone (DEX) decreased Wnt16 mRNA levels in murine bone marrow stromal cells (mBMSCs) time- and dose-dependently.
      Title: Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo.
    9. WNT16 is a crucial regulator of cortical bone thickness in young adult and old mice. New treatment strategies targeting the adult regulation of WNT16 might be useful to reduce fracture risk at cortical bone sites.
      Title: Inducible Wnt16 inactivation: WNT16 regulates cortical bone thickness in adult mice.
    10. Glucocorticoids (GC) treatment decreases Wnt16 mRNA levels in bone and WNT16 overexpression partly protects against GC-induced bone loss.
      Title: WNT16 overexpression partly protects against glucocorticoid-induced bone loss.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cardiac epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oxidative stress-induced premature senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replicative senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein Wnt-16
    Names
    wingless-related MMTV integration site 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053116.4 → NP_444346.3  protein Wnt-16 precursor

      See identical proteins and their annotated locations for NP_444346.3

      Status: VALIDATED

      Source sequence(s)
      AK053805, AK054110, BC115925
      Consensus CDS
      CCDS19936.1
      UniProtKB/Swiss-Prot
      Q14BF7, Q9QYS1
      UniProtKB/TrEMBL
      Q8C6P4
      Related
      ENSMUSP00000031681.4, ENSMUST00000031681.10
      Conserved Domains (1) summary
      pfam00110
      Location:52 → 364
      wnt; wnt family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      22288179..22298521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505214.5 → XP_006505277.1  protein Wnt-16 isoform X1

      See identical proteins and their annotated locations for XP_006505277.1

      UniProtKB/TrEMBL
      H3BJ29, Q8BRT3
      Related
      ENSMUSP00000135016.2, ENSMUST00000148639.2
      Conserved Domains (1) summary
      cl38924
      Location:52 → 210
      Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYS1.2 GenPept UniProtKB/Swiss-Prot:Q9QYS1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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