Erp29 endoplasmic reticulum protein 29 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Erp29provided by MGI
Official Full Name: endoplasmic reticulum protein 29provided by MGI
Primary source: MGI:MGI:1914647
See related: Ensembl:ENSMUSG00000029616 AllianceGenome:MGI:1914647
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Erp28; Erp31; PDI-Db; 1200015M03Rik; 2810446M09Rik
Summary: Predicted to enable chaperone binding activity and protein homodimerization activity. Involved in regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in cell surface. Is expressed in Meckel's cartilage and pancreas epithelium. Orthologous to human ERP29 (endoplasmic reticulum protein 29). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 91.8), ovary adult (RPKM 52.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 61.8 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (121582816..121590537, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (121444753..121452474, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulatory role of endoplasmic reticulum resident chaperone protein ERp29 in anti-murine beta-coronavirus host cell response.
Title: Regulatory role of endoplasmic reticulum resident chaperone protein ERp29 in anti-murine β-coronavirus host cell response.
The anti-aggregation peptide ReACp53 significantly decreased ERP29 expression and suppressed the chemoresistant effect. These findings highlight a role of ERP29 in the acquired chemoresistance of cancer cells expressing the aggregating p53 mutant Arg282Trp.
Title: Proteomic identification of ERP29 as a key chemoresistant factor activated by the aggregating p53 mutant Arg282Trp.
Erp29 may have an important role in Endoplasmic reticulum stress in islet beta cells.
Title: Endoplasmic reticulum protein 29 is involved in endoplasmic reticulum stress in islet beta cells.
ERp29 acts as an escort factor for ATF6 and promotes its transport from ER to Golgi apparatus under ER stress conditions.
Title: ERp29 deficiency affects sensitivity to apoptosis via impairment of the ATF6-CHOP pathway of stress response.
Results identify ERp29 as a novel regulator of PERK and provide evidence for the role of ER resident factors in the regulation of chemotherapeutic efficacy.
Title: ERp29 regulates response to doxorubicin by a PERK-mediated mechanism.
A network of endoplasmic reticulum ERp57, ERp72, and ERp29 facilitate polyomavirus infection.
Title: A PDI family network acts distinctly and coordinately with ERp29 to facilitate polyomavirus infection.
Endoplasmic reticulum protein 29 (ERp29) is involved in sperm-oocyte fusion in mouse.
Title: Endoplasmic reticulum protein 29 (ERp29), a protein related to sperm maturation is involved in sperm-oocyte fusion in mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info	PubMed
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in smooth endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: endoplasmic reticulum resident protein 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026129.2 → NP_080405.1 endoplasmic reticulum resident protein 29 precursor

See identical proteins and their annotated locations for NP_080405.1

Status: PROVISIONAL

Source sequence(s)

BC017125

Consensus CDS

CCDS19634.1

UniProtKB/Swiss-Prot

P57759, Q3THW3, Q9CQ42

Related

ENSMUSP00000117347.2, ENSMUST00000130451.2

Conserved Domains (2) summary

pfam07749
Location:159 → 252

ERp29; Endoplasmic reticulum protein ERp29, C-terminal domain

cl00388
Location:35 → 157

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold