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    St7 suppression of tumorigenicity 7 [ Mus musculus (house mouse) ]

    Gene ID: 64213, updated on 5-Mar-2024

    Summary

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    Official Symbol
    St7provided by MGI
    Official Full Name
    suppression of tumorigenicity 7provided by MGI
    Primary source
    MGI:MGI:1927450
    See related
    Ensembl:ENSMUSG00000029534 AllianceGenome:MGI:1927450
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HELG; RAY1; SEN4; TSG7; Fam4a2; 9430001H04Rik
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in brain; early conceptus; secondary oocyte; and spinal cord. Orthologous to human ST7 (suppression of tumorigenicity 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 8.2), whole brain E14.5 (RPKM 7.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 A2; 6 8.0 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (17693579..17943022)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (17693901..17943023)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15256 Neighboring gene predicted gene, 53318 Neighboring gene STARR-positive B cell enhancer ABC_E9662 Neighboring gene capping actin protein of muscle Z-line subunit alpha 2 Neighboring gene STARR-positive B cell enhancer mm9_chr6:17682030-17682331 Neighboring gene four and a half LIM domains 3 pseudogene Neighboring gene metal response element binding transcription factor 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15259 Neighboring gene STARR-positive B cell enhancer mm9_chr6:17726341-17726642 Neighboring gene predicted gene, 52895 Neighboring gene STARR-seq mESC enhancer starr_15260 Neighboring gene STARR-seq mESC enhancer starr_15261 Neighboring gene STARR-seq mESC enhancer starr_15263 Neighboring gene wingless-type MMTV integration site family, member 2 Neighboring gene ankyrin repeat, SAM and basic leucine zipper domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of mouse St7r (St7-like, St7l). Saitoh T, et al. Int J Mol Med, 2002 Jul. PMID 12060862
    2. Identification of a novel gene on chromosome 7q31 that is interrupted by a translocation breakpoint in an autistic individual. Vincent JB, et al. Am J Hum Genet, 2000 Aug. PMID 10889047, Free PMC Article
    3. Assessment of F-MuLV-induced tumorigenesis reveals new candidate tumor genes including Pecam1, St7, and Prim2. Yatsula B, et al. Leukemia, 2006 Jan. PMID 16307020
    4. Met proto-oncogene juxtamembrane rare variations in mouse and humans: differential effects of Arg and Cys alleles on mouse lung tumorigenesis. Zaffaroni D, et al. Oncogene, 2005 Feb 3. PMID 15592501
    5. Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31. Zenklusen JC, et al. Nat Genet, 2001 Apr. PMID 11279520

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. suppressor of tumorigenicity 7 (ST7) and nonmetastatic 23 (NM23) are direct targets of PRMT5-containing BRG1 and hBRM complexes
      Title: Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118540

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    suppressor of tumorigenicity 7 protein
    Names
    4low density lipoprotein-related protein 12
    family with sequence similarity 4, subfamily A, member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083315.2 → NP_001076784.1  suppressor of tumorigenicity 7 protein isoform 2

      See identical proteins and their annotated locations for NP_001076784.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC068561, AK079107, AK132103
      Consensus CDS
      CCDS39431.1
      UniProtKB/TrEMBL
      D3YUM7
      Related
      ENSMUSP00000111077.4, ENSMUST00000115417.4
      Conserved Domains (1) summary
      cd11557
      Location:11 → 475
      ST7; Suppression of tumorigenicity 7

    2. NM_001289624.1 → NP_001276553.1  suppressor of tumorigenicity 7 protein isoform 3

      See identical proteins and their annotated locations for NP_001276553.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AC068561, AC153836
      Consensus CDS
      CCDS71728.1
      UniProtKB/Swiss-Prot
      Q3UA20, Q6Q9W2, Q6Q9W3, Q8R3T3, Q921F6, Q99M89, Q99M90, Q99M91, Q99M92, Q99M93, Q99M94, Q99M96, Q9JID7, Q9JID8
      UniProtKB/TrEMBL
      D3YUM7
      Related
      ENSMUSP00000080341.7, ENSMUST00000081635.13
      Conserved Domains (1) summary
      pfam04184
      Location:19 → 576
      ST7; ST7 protein

    3. NM_001289625.1 → NP_001276554.1  suppressor of tumorigenicity 7 protein isoform 4

      See identical proteins and their annotated locations for NP_001276554.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, uses an alternate in-frame splice site, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AC068561, AC153836
      Consensus CDS
      CCDS80490.1
      UniProtKB/TrEMBL
      D3YUM7
      Related
      ENSMUSP00000111079.2, ENSMUST00000115419.8
      Conserved Domains (1) summary
      pfam04184
      Location:19 → 571
      ST7; ST7 protein

    4. NM_001289626.1 → NP_001276555.1  suppressor of tumorigenicity 7 protein isoform 5

      See identical proteins and their annotated locations for NP_001276555.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and lacks an alternate in-frame exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AC068561, AC153836
      Consensus CDS
      CCDS71729.1
      UniProtKB/TrEMBL
      D3YUM7, Q99M95
      Related
      ENSMUSP00000062886.6, ENSMUST00000052113.12
      Conserved Domains (1) summary
      pfam04184
      Location:19 → 553
      ST7; ST7 protein

    5. NM_001289627.1 → NP_001276556.1  suppressor of tumorigenicity 7 protein isoform 6

      See identical proteins and their annotated locations for NP_001276556.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (6) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC068561, AC153836
      Consensus CDS
      CCDS71730.1
      UniProtKB/TrEMBL
      D3YUM7
      Related
      ENSMUSP00000076334.3, ENSMUST00000077080.9
      Conserved Domains (1) summary
      pfam04184
      Location:4 → 530
      ST7; ST7 protein

    6. NM_001289629.1 → NP_001276558.1  suppressor of tumorigenicity 7 protein isoform 7

      See identical proteins and their annotated locations for NP_001276558.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region and lacks an alternate in-frame exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (7) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC068561, AC153836
      Consensus CDS
      CCDS71731.1
      UniProtKB/TrEMBL
      D3YUM7
      Related
      ENSMUSP00000000674.7, ENSMUST00000000674.13
      Conserved Domains (1) summary
      pfam04184
      Location:4 → 507
      ST7; ST7 protein

    7. NM_022332.3 → NP_071727.2  suppressor of tumorigenicity 7 protein isoform 1

      See identical proteins and their annotated locations for NP_071727.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AK079107, BC108418, BY479263
      Consensus CDS
      CCDS19927.1
      UniProtKB/TrEMBL
      D3YUM7
      Related
      ENSMUSP00000057326.8, ENSMUST00000053148.14
      Conserved Domains (1) summary
      cd11557
      Location:11 → 498
      ST7; Suppression of tumorigenicity 7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      17693579..17943022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241076.4 → XP_011239378.1  suppressor of tumorigenicity 7 protein isoform X1

      Conserved Domains (1) summary
      cd11557
      Location:1 → 377
      ST7; Suppression of tumorigenicity 7

    RNA

    1. XR_004933617.1 RNA Sequence

    2. XR_868763.4 RNA Sequence

    3. XR_868764.4 RNA Sequence

    4. XR_003956242.2 RNA Sequence

    5. XR_377290.5 RNA Sequence

    6. XR_003956244.2 RNA Sequence

    7. XR_003956243.2 RNA Sequence

    8. XR_377291.5 RNA Sequence

    9. XR_003956245.2 RNA Sequence

    10. XR_003956246.2 RNA Sequence

    11. XR_003956247.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99M96.1 GenPept UniProtKB/Swiss-Prot:Q99M96

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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