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    Snrnp35 small nuclear ribonucleoprotein 35 (U11/U12) [ Mus musculus (house mouse) ]

    Gene ID: 76167, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Snrnp35provided by MGI
    Official Full Name
    small nuclear ribonucleoprotein 35 (U11/U12)provided by MGI
    Primary source
    MGI:MGI:1923417
    See related
    Ensembl:ENSMUSG00000029402 AllianceGenome:MGI:1923417
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330548G22Rik
    Summary
    Predicted to enable mRNA binding activity and snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleolus. Predicted to be part of U12-type spliceosomal complex. Is expressed in several structures, including brain; central nervous system ganglion; and retina. Orthologous to human SNRNP35 (small nuclear ribonucleoprotein U11/U12 subunit 35). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 8.8), CNS E11.5 (RPKM 6.3) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 F; 5 63.61 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124621099..124631649)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124483081..124493586)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene lysine methyltransferase 5A Neighboring gene Rab interacting lysosomal protein-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E8082 Neighboring gene STARR-positive B cell enhancer ABC_E11302 Neighboring gene STARR-positive B cell enhancer ABC_E2178 Neighboring gene STARR-positive B cell enhancer ABC_E6382 Neighboring gene peptidylprolyl isomerase A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10352 Neighboring gene predicted gene, 52789 Neighboring gene Rab interacting lysosomal protein-like 1 Neighboring gene ribosomal protein L32 5C pseudogene Neighboring gene transmembrane p24 trafficking protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent introns. Doktor TK, et al. Nucleic Acids Res, 2017 Jan 9. PMID 27557711, Free PMC Article
    2. Minor spliceosome components are predominantly localized in the nucleus. Pessa HK, et al. Proc Natl Acad Sci U S A, 2008 Jun 24. PMID 18559850, Free PMC Article
    3. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article
    4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Elevated U12-intron retention has been demonstrated in all examined tissues from spinal muscular atrophy mice.
      Title: RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent introns.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U12-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U12-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U11/U12 small nuclear ribonucleoprotein 35 kDa protein
    Names
    U1 snRNP-binding protein homolog
    U11/U12 snRNP 35 kDa protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029532.2 → NP_083808.1  U11/U12 small nuclear ribonucleoprotein 35 kDa protein

      See identical proteins and their annotated locations for NP_083808.1

      Status: PROVISIONAL

      Source sequence(s)
      BC043031
      Consensus CDS
      CCDS19677.1
      UniProtKB/Swiss-Prot
      Q8CAC7, Q9D384
      Related
      ENSMUSP00000031349.9, ENSMUST00000031349.9
      Conserved Domains (1) summary
      cd12237
      Location:48 → 137
      RRM_snRNP35; RNA recognition motif found in U11/U12 small nuclear ribonucleoprotein 35 kDa protein (U11/U12-35K) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      124621099..124631649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530495.5 → XP_006530558.1  U11/U12 small nuclear ribonucleoprotein 35 kDa protein isoform X1

      See identical proteins and their annotated locations for XP_006530558.1

      UniProtKB/Swiss-Prot
      Q8CAC7, Q9D384
      Conserved Domains (1) summary
      cd12237
      Location:48 → 137
      RRM_snRNP35; RNA recognition motif found in U11/U12 small nuclear ribonucleoprotein 35 kDa protein (U11/U12-35K) and similar proteins

    2. XM_006530494.5 → XP_006530557.1  U11/U12 small nuclear ribonucleoprotein 35 kDa protein isoform X1

      See identical proteins and their annotated locations for XP_006530557.1

      UniProtKB/Swiss-Prot
      Q8CAC7, Q9D384
      Related
      ENSMUSP00000107080.2, ENSMUST00000111453.2
      Conserved Domains (1) summary
      cd12237
      Location:48 → 137
      RRM_snRNP35; RNA recognition motif found in U11/U12 small nuclear ribonucleoprotein 35 kDa protein (U11/U12-35K) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D384.1 GenPept UniProtKB/Swiss-Prot:Q9D384

    Gene LinkOut

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