Rhoh ras homolog family member H [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rhohprovided by MGI
Official Full Name: ras homolog family member Hprovided by MGI
Primary source: MGI:MGI:1921984
See related: Ensembl:ENSMUSG00000029204 AllianceGenome:MGI:1921984
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Arhh; 5830400A04Rik
Summary: Predicted to enable several functions, including GTP binding activity; GTPase activity; and kinase inhibitor activity. Involved in T cell differentiation and mast cell activation. Located in cytoplasm and immunological synapse. Is expressed in cranial ganglion; dorsal root ganglion; and sensory organ. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human RHOH (ras homolog family member H). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 18.6), spleen adult (RPKM 6.0) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C3.1; 5 33.8 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (66018092..66054043)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (65860742..65896700)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nascent RHOH acts as a molecular brake on actomyosin-mediated effector functions of inflammatory neutrophils.
Title: Nascent RHOH acts as a molecular brake on actomyosin-mediated effector functions of inflammatory neutrophils.
Deletion of murine Rhoh leads to de-repression of Bcl-6 via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma.
Title: Deletion of murine Rhoh leads to de-repression of Bcl-6 via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma.
RhoH deficiency in mice induced TH17 polarization during effector T-cell differentiation, thereby inducing psoriasis-like chronic dermatitis
Title: Ras homolog gene family H (RhoH) deficiency induces psoriasis-like chronic dermatitis by promoting T(H)17 cell polarization.
These results highlight a novel negative regulatory role for RhoH in eosinophil differentiation, most likely in consequence of altered GATA-2 levels.
Title: RhoH is a negative regulator of eosinophilopoiesis.
An excess amount of RhoH is able to initiate pre-TCR signaling in the absence of pre-TCR complexes.
Title: Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint.
The C-terminal insert domain regulates RhoH protein stability via chaperone-mediated autophagy.
Title: A unique carboxyl-terminal insert domain in the hematopoietic-specific, GTPase-deficient Rho GTPase RhoH regulates post-translational processing.
RhoH plays a critical role in prosurvival chronic lymphocytic leukemia cell-cell and cell-microenvironment interactions with this agent.
Title: RhoH is critical for cell-microenvironment interactions in chronic lymphocytic leukemia in mice and humans.
Results suggest that RhoH regulates TCR signaling via recruitment of ZAP-70 and Lck to CD3zeta in the immunological synapse.
Title: RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling.
These findings stress the importance of Rhoh for the function of peripheral T cells.
Title: Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection.
RhoH has a function in the progression of B-cell chronic lymphocytic leukemia (CLL) in a murine model and show RhoH expression is altered in human primary lymphocytic (CLL) samples.
Title: Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB155983 (e-PCR)
- UniSTS:185624

RH136287 (e-PCR)
- UniSTS:210280

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mast cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: rho-related GTP-binding protein RhoH

Names: ras homolog gene family, member H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081105.2 → NP_001074574.1 rho-related GTP-binding protein RhoH

See identical proteins and their annotated locations for NP_001074574.1

Status: VALIDATED

Source sequence(s)

AC156029

Consensus CDS

CCDS39100.1

UniProtKB/Swiss-Prot

Q9D3G9

UniProtKB/TrEMBL

Q3TEI3, Q504M6

Related

ENSMUSP00000143810.2, ENSMUST00000201533.2

Conserved Domains (1) summary

cd00157
Location:5 → 169

Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)
NM_001363454.1 → NP_001350383.1 rho-related GTP-binding protein RhoH

Status: VALIDATED

Source sequence(s)

AC156029, AI448508, AK137909, AK138090

Consensus CDS

CCDS39100.1

UniProtKB/Swiss-Prot

Q9D3G9

UniProtKB/TrEMBL

Q3TEI3, Q504M6

Related

ENSMUSP00000031106.5, ENSMUST00000031106.8

Conserved Domains (1) summary

cd00157
Location:5 → 169

Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

66018092..66054043

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254861.2 → XP_030110721.1 rho-related GTP-binding protein RhoH isoform X1

UniProtKB/Swiss-Prot

Q9D3G9

UniProtKB/TrEMBL

Q3TEI3, Q504M6

Conserved Domains (1) summary

cd00157
Location:5 → 169

Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)
XM_011240779.4 → XP_011239081.1 rho-related GTP-binding protein RhoH isoform X1

See identical proteins and their annotated locations for XP_011239081.1

UniProtKB/Swiss-Prot

Q9D3G9

UniProtKB/TrEMBL

Q3TEI3, Q504M6

Conserved Domains (1) summary

cd00157
Location:5 → 169

Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)