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    Kcnip4 Kv channel interacting protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 80334, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Kcnip4provided by MGI
    Official Full Name
    Kv channel interacting protein 4provided by MGI
    Primary source
    MGI:MGI:1933131
    See related
    Ensembl:ENSMUSG00000029088 AllianceGenome:MGI:1933131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Calp; KChIP4; Calp250; KChIP4a
    Summary
    Enables calcium ion binding activity and potassium channel regulator activity. Involved in regulation of potassium ion transmembrane transport. Part of voltage-gated potassium channel complex. Is expressed in brain; dorsal root ganglion; meninges; retina; and spinal cord. Orthologous to human KCNIP4 (potassium voltage-gated channel interacting protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 12.2), cortex adult (RPKM 6.6) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 B3; 5 26.26 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (48546845..49682464, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (48389503..49525122, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene slit guidance ligand 2 Neighboring gene microRNA 218-1 Neighboring gene STARR-seq mESC enhancer starr_13026 Neighboring gene STARR-positive B cell enhancer ABC_E4755 Neighboring gene RIKEN cDNA 5730480H06 gene Neighboring gene PARK2 co-regulated-like Neighboring gene STARR-seq mESC enhancer starr_13027 Neighboring gene predicted gene, 52772 Neighboring gene STARR-seq mESC enhancer starr_13028 Neighboring gene STARR-seq mESC enhancer starr_13030 Neighboring gene STARR-seq mESC enhancer starr_13031 Neighboring gene dyskeratosis congenita 1, dyskerin homolog pseudogene Neighboring gene predicted gene 10048 Neighboring gene STARR-seq mESC enhancer starr_13032 Neighboring gene STARR-seq mESC enhancer starr_13033 Neighboring gene cytochrome c-like Neighboring gene STARR-seq mESC enhancer starr_13034 Neighboring gene predicted gene, 54297 Neighboring gene NSFL1 (p97) cofactor (p47) pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NMR analysis of KChIP4a reveals structural basis for control of surface expression of Kv4 channel complexes. Schwenk J, et al. J Biol Chem, 2008 Jul 4. PMID 18458082, Free PMC Article
    2. Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. Himes BE, et al. PLoS One, 2013. PMID 23457522, Free PMC Article
    3. Functional rescue of Kv4.3 channel tetramerization mutants by KChIP4a. Liang P, et al. Biophys J, 2010 Jun 16. PMID 20550899, Free PMC Article
    4. Structural Insights into KChIP4a Modulation of Kv4.3 Inactivation. Liang P, et al. J Biol Chem, 2009 Feb 20. PMID 19109250
    5. Differential distribution of KChIPs mRNAs in adult mouse brain. Xiong H, et al. Brain Res Mol Brain Res, 2004 Sep 28. PMID 15363885

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genome-wide association study identifies KCNIP4 as an asthma gene in human and in mouse.
      Title: Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene.
    2. KChIP4a functions to promote tetrameric assembly and enhance surface expression of Kv4 channels.
      Title: Functional rescue of Kv4.3 channel tetramerization mutants by KChIP4a.
    3. These data demonstrate that PKA phosphorylation of Kv4.2 plays an important role in the trafficking of Kv4.2 through its specific interaction with KChIP4a.
      Title: KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation.
    4. N-terminal binding of Kv4.3 to the core of KChIP4a mobilizes the KChIP4a N terminus, which serves as the slow inactivation gate.
      Title: Structural Insights into KChIP4a Modulation of Kv4.3 Inactivation.
    5. Surface expression of Kv4 complexes may thus be controlled by an auto-inhibitory domain in the KChIP subunit.
      Title: NMR analysis of KChIP4a reveals structural basis for control of surface expression of Kv4 channel complexes.
    6. KChIP4 was highly expressed by neurons in layers II-IV of cortex and in hippocampus, thalamus and the Purkinje cell layer of the cerebellum.
      Title: Differential distribution of KChIPs mRNAs in adult mouse brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Kv channel-interacting protein 4
    Names
    A-type potassium channel modulatory protein 4
    calsenilin-like protein
    potassium channel interacting protein 4

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199242.1 → NP_001186171.1  Kv channel-interacting protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001186171.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1)
      Source sequence(s)
      AK148685, BC051130
      Consensus CDS
      CCDS57342.1
      UniProtKB/Swiss-Prot
      Q6DTJ3, Q6PHZ8, Q8CAD0, Q8R4I2, Q9EQ01
      UniProtKB/TrEMBL
      Q3YAA8
      Related
      ENSMUSP00000084656.5, ENSMUST00000087395.11
      Conserved Domains (1) summary
      COG5126
      Location:80 → 239
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. NM_001199243.1 → NP_001186172.1  Kv channel-interacting protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001186172.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame 5' exon, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AK148685, BC051130, DQ148502
      Consensus CDS
      CCDS57341.1
      UniProtKB/TrEMBL
      Q3YAA7
      Related
      ENSMUSP00000135071.3, ENSMUST00000176191.8
      Conserved Domains (1) summary
      COG5126
      Location:46 → 205
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    3. NM_001199244.1 → NP_001186173.1  Kv channel-interacting protein 4 isoform 5

      See identical proteins and their annotated locations for NP_001186173.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has a distinct 5' end, compared to variant (1), which results in an isoform (5) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK148685
      Consensus CDS
      CCDS57340.1
      UniProtKB/TrEMBL
      Q3UFC0
      Related
      ENSMUSP00000135799.2, ENSMUST00000175660.5
      Conserved Domains (1) summary
      COG5126
      Location:55 → 214
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    4. NM_001199245.1 → NP_001186174.1  Kv channel-interacting protein 4 isoform 6

      See identical proteins and their annotated locations for NP_001186174.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has a distinct 5' end, compared to variant (1), which results in an isoform (6) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK148685, DQ148504
      Consensus CDS
      CCDS57339.1
      UniProtKB/TrEMBL
      Q3YAA5
      Related
      ENSMUSP00000131276.2, ENSMUST00000166924.8
      Conserved Domains (1) summary
      COG5126
      Location:63 → 222
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    5. NM_030265.3 → NP_084541.3  Kv channel-interacting protein 4 isoform 4

      See identical proteins and their annotated locations for NP_084541.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has a distinct 5' end, compared to variant (1), which results in an isoform (4) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK039048, AK148685
      Consensus CDS
      CCDS39084.1
      UniProtKB/TrEMBL
      Q3YAA6
      Related
      ENSMUSP00000134758.2, ENSMUST00000176978.8
      Conserved Domains (1) summary
      COG5126
      Location:59 → 218
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      48546845..49682464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165622.1 → XP_036021515.1  Kv channel-interacting protein 4 isoform X5

      Conserved Domains (1) summary
      COG5126
      Location:29 → 188
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. XM_036165624.1 → XP_036021517.1  Kv channel-interacting protein 4 isoform X7

      UniProtKB/TrEMBL
      Q3V060
      Conserved Domains (1) summary
      COG5126
      Location:18 → 177
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    3. XM_030254922.2 → XP_030110782.1  Kv channel-interacting protein 4 isoform X7

      UniProtKB/TrEMBL
      Q3V060
      Conserved Domains (1) summary
      COG5126
      Location:18 → 177
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    4. XM_030254920.1 → XP_030110780.1  Kv channel-interacting protein 4 isoform X4

      Conserved Domains (1) summary
      COG5126
      Location:46 → 152
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    5. XM_030254917.1 → XP_030110777.1  Kv channel-interacting protein 4 isoform X1

      Conserved Domains (1) summary
      COG5126
      Location:80 → 186
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    6. XM_030254919.1 → XP_030110779.1  Kv channel-interacting protein 4 isoform X3

      Conserved Domains (1) summary
      COG5126
      Location:59 → 165
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    7. XM_036165623.1 → XP_036021516.1  Kv channel-interacting protein 4 isoform X6

      Conserved Domains (1) summary
      COG5126
      Location:18 → 124
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    8. XM_030254921.1 → XP_030110781.1  Kv channel-interacting protein 4 isoform X6

      Conserved Domains (1) summary
      COG5126
      Location:18 → 124
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    9. XM_030254918.1 → XP_030110778.1  Kv channel-interacting protein 4 isoform X2

      Conserved Domains (1) summary
      COG5126
      Location:63 → 169
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PHZ8.1 GenPept UniProtKB/Swiss-Prot:Q6PHZ8

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