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    Acap3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 [ Mus musculus (house mouse) ]

    Gene ID: 140500, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Acap3provided by MGI
    Official Full Name
    ArfGAP with coiled-coil, ankyrin repeat and PH domains 3provided by MGI
    Primary source
    MGI:MGI:2153589
    See related
    Ensembl:ENSMUSG00000029033 AllianceGenome:MGI:2153589
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Centb5; mKIAA1716; Kiaa1716-hp
    Summary
    Enables GTPase activator activity. Acts upstream of or within neuron migration and regulation of neuron projection development. Located in growth cone. Is expressed in several structures, including adipose tissue; brain; genitourinary system; liver; and spleen. Orthologous to human ACAP3 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 26.0), CNS E18 (RPKM 24.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 E2; 4 87.66 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155976332..155991708)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155891875..155907251)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1671 Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene integrator complex subunit 11 Neighboring gene STARR-positive B cell enhancer ABC_E9250 Neighboring gene STARR-seq mESC enhancer starr_12276 Neighboring gene pseudouridylate synthase-like 1 Neighboring gene sodium channel, nonvoltage-gated 1, delta Neighboring gene STARR-positive B cell enhancer ABC_E10298 Neighboring gene STARR-seq mESC enhancer starr_12277 Neighboring gene ubiquitin-conjugating enzyme E2J 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. [CENTB5 gene expression in human and mouse]. Shubina DM, et al. Mol Biol (Mosk), 2009 May-Jun. PMID 19548526
    2. ACAP3, the GTPase-activating protein specific to the small GTPase Arf6, regulates neuronal migration in the developing cerebral cortex. Miura Y, et al. Biochem Biophys Res Commun, 2017 Nov 18. PMID 28919417
    3. ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons. Miura Y, et al. Biochem J, 2016 Sep 1. PMID 27330119
    4. Positional cloning of the mouse saccharin preference (Sac) locus. Bachmanov AA, et al. Chem Senses, 2001 Sep. PMID 11555487, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ACAP3 is involved in neuronal migration in the developing cerebral cortex of mice. Knockdown of ACAP3 in the developing cortical neurons of mice in utero significantly abrogated neuronal migration in the cortical layer, which was restored by ectopic expression of wild type of ACAP3, but not by its GTPase-activating protein - inactive mutant.
      Title: ACAP3, the GTPase-activating protein specific to the small GTPase Arf6, regulates neuronal migration in the developing cerebral cortex.
    2. cycling between active and inactive forms of Arf6, which is precisely regulated by ACAP3 in concert with a guanine-nucleotide-exchange factor(s), seems to be required for neurite outgrowth of hippocampal neurons
      Title: ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons.
    3. minisatellite locus UPS29 can regulate an activity of CENTB5, SCNN1D and ACOT7 in nervous system cells.
      Title: [CENTB5 gene expression in human and mouse].
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3
    Names
    centaurin, beta 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207223.1 → NP_997106.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3

      See identical proteins and their annotated locations for NP_997106.1

      Status: PROVISIONAL

      Source sequence(s)
      BC067016
      Consensus CDS
      CCDS38997.1
      UniProtKB/TrEMBL
      Q3UH98, Q6NXL5
      Related
      ENSMUSP00000101209.4, ENSMUST00000105584.10
      Conserved Domains (7) summary
      cd07637
      Location:16 → 215
      BAR_ACAP3; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 3
      cd00204
      Location:671 → 786
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:271 → 367
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:269 → 363
      PH; PH domain
      pfam01412
      Location:403 → 521
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:671 → 764
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:700 → 731
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      155976332..155991708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538541.5 → XP_006538604.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006538604.1

      UniProtKB/TrEMBL
      Q3UH98
      Related
      ENSMUST00000137726.8
      Conserved Domains (5) summary
      PTZ00322
      Location:663 → 758
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd13250
      Location:229 → 325
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:658 → 689
      ANK; ANK repeat [structural motif]
      cd08850
      Location:361 → 476
      ArfGap_ACAP3; ArfGAP domain of ACAP3 (ArfGAP with Coiled-coil, ANK repeat and PH domains 3)
      cl12013
      Location:1 → 173
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_006538542.3 → XP_006538605.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006538605.1

      UniProtKB/TrEMBL
      Q3UH98
      Conserved Domains (5) summary
      PTZ00322
      Location:663 → 758
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd13250
      Location:229 → 325
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:658 → 689
      ANK; ANK repeat [structural motif]
      cd08850
      Location:361 → 476
      ArfGap_ACAP3; ArfGAP domain of ACAP3 (ArfGAP with Coiled-coil, ANK repeat and PH domains 3)
      cl12013
      Location:1 → 173
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein Strain
    Heading Accession and Version

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