Per3 period circadian clock 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Per3provided by MGI
Official Full Name: period circadian clock 3provided by MGI
Primary source: MGI:MGI:1277134
See related: Ensembl:ENSMUSG00000028957 AllianceGenome:MGI:1277134
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mPer3; 2810049O06Rik
Summary: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Expression: Broad expression in bladder adult (RPKM 14.0), cortex adult (RPKM 6.1) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 81.53 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (151081475..151129167, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (150997018..151044707, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clock gene Per3 deficiency disrupts circadian alterations of gut microbiota in mice.
Title: Clock gene Per3 deficiency disrupts circadian alterations of gut microbiota in mice.
The studies demonstrate that the Per1, Per2, and Par3 genes are not necessary for the expression of food anticipatory activity in mice.
Title: mPeriod2 (Brdm1) and other single Period mutant mice have normal food anticipatory activity.
Period genes not only orchestrate dynamic changes in metabolic activity, but also regulate homeostatic self-renewal of hepatocytes through Mkp1-Erk1/2 signaling pathway.
Title: Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway.
When treated with imipramine, neither Per3(-/-) nor WT mice exhibited an anhedonia-like phenotype, and neither genotypes exhibited a delay in behavioural timing in responses to dLAN. While the association between both Per3(-/-) phenotypes remains unclear, both are alleviated by imipramine treatment during dim night-time light.
Title: Transient anhedonia phenotype and altered circadian timing of behaviour during night-time dim light exposure in Per3(-/-) mice, but not wildtype mice.
The findings demonstrate that Per3 has a major role in the APC clock and regulates adipogenesis in vivo.
Title: The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15.
TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1
Title: TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1.
Post-transcriptional mRNA stability modulation controls the phase for circadian mPer3 expression.
Title: Rhythmic control of mRNA stability modulates circadian amplitude of mouse Period3 mRNA.
Per3 is involved in the suppression of behavioural activity in direct response to light.
Title: The effect of different photoperiods in circadian rhythms of per3 knockout mice.
evidence for an association of PER3 polymorphisms with juvenile myoclonic epilepsy.
Title: PER2 rs2304672, CLOCK rs1801260, and PER3 rs57875989 polymorphisms are not associated with juvenile myoclonic epilepsy.
Our data provide strong evidence that variation in the Per3 transcript is causally associated with and also responsive to stress and alcohol.
Title: A promoter polymorphism in the Per3 gene is associated with alcohol and stress response.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:235102 (e-PCR)
- UniSTS:235102

AU043392 (e-PCR)
- UniSTS:159329

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in circadian regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
involved_in entrainment of circadian clock by photoperiod	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian sleep/wake cycle, sleep	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: period circadian protein homolog 3

Names: circadian clock protein PERIOD 3; period homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289877.1 → NP_001276806.1 period circadian protein homolog 3 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AL607143

UniProtKB/TrEMBL

B9EIT7

Conserved Domains (3) summary

cd00130
Location:280 → 372

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08447
Location:280 → 368

PAS_3; PAS fold

pfam12114
Location:908 → 1111

Period_C; Period protein 2/3C-terminal region
NM_001289878.1 → NP_001276807.1 period circadian protein homolog 3 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate exon and uses a downstream start codon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL607143

Conserved Domains (1) summary

pfam12114
Location:701 → 797

Period_C; Period protein 2/3C-terminal region
NM_011067.3 → NP_035197.2 period circadian protein homolog 3 isoform 2

See identical proteins and their annotated locations for NP_035197.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.

Source sequence(s)

AL607143

Consensus CDS

CCDS18978.1

UniProtKB/Swiss-Prot

A2A894, O70361

UniProtKB/TrEMBL

B9EIT7

Related

ENSMUSP00000099493.5, ENSMUST00000103204.11

Conserved Domains (3) summary

cd00130
Location:280 → 372

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08447
Location:280 → 368

PAS_3; PAS fold

pfam12114
Location:907 → 1110

Period_C; Period protein 2/3C-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

151081475..151129167 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163827.1 → XP_036019720.1 period circadian protein homolog 3 isoform X7

UniProtKB/TrEMBL

B9EIT7

Conserved Domains (2) summary

pfam08447
Location:280 → 368

PAS_3; PAS fold

pfam12114
Location:864 → 1040

Period_C; Period protein 2/3C-terminal region
XM_017320034.3 → XP_017175523.2 period circadian protein homolog 3 isoform X4

UniProtKB/TrEMBL

B9EIT7

Conserved Domains (2) summary

pfam08447
Location:280 → 368

PAS_3; PAS fold

pfam12114
Location:905 → 1081

Period_C; Period protein 2/3C-terminal region
XM_017320032.3 → XP_017175521.1 period circadian protein homolog 3 isoform X2

UniProtKB/TrEMBL

B9EIT7

Conserved Domains (2) summary

pfam08447
Location:280 → 368

PAS_3; PAS fold

pfam12114
Location:906 → 1082

Period_C; Period protein 2/3C-terminal region
XM_017320033.3 → XP_017175522.1 period circadian protein homolog 3 isoform X3

UniProtKB/TrEMBL

B9EIT7

Conserved Domains (2) summary

pfam08447
Location:280 → 368

PAS_3; PAS fold

pfam12114
Location:906 → 1082

Period_C; Period protein 2/3C-terminal region
XM_017320031.3 → XP_017175520.1 period circadian protein homolog 3 isoform X1

UniProtKB/TrEMBL

B9EIT7

Conserved Domains (2) summary

pfam08447
Location:280 → 368

PAS_3; PAS fold

pfam12114
Location:907 → 1083

Period_C; Period protein 2/3C-terminal region
XM_030253311.2 → XP_030109171.1 period circadian protein homolog 3 isoform X8

Conserved Domains (1) summary

pfam12114
Location:591 → 767

Period_C; Period protein 2/3C-terminal region
XM_017320036.3 → XP_017175525.1 period circadian protein homolog 3 isoform X9

Conserved Domains (1) summary

pfam12114
Location:588 → 764

Period_C; Period protein 2/3C-terminal region
XM_036163826.1 → XP_036019719.1 period circadian protein homolog 3 isoform X6

UniProtKB/TrEMBL

B9EIT7

Conserved Domains (2) summary

pfam08447
Location:280 → 368

PAS_3; PAS fold

pfam12114
Location:905 → 1109

Period_C; Period protein 2/3C-terminal region
XM_011250203.4 → XP_011248505.1 period circadian protein homolog 3 isoform X5

UniProtKB/TrEMBL

B9EIT7

Conserved Domains (2) summary

pfam08447
Location:280 → 368

PAS_3; PAS fold

pfam12114
Location:906 → 1110

Period_C; Period protein 2/3C-terminal region