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    Rragc Ras-related GTP binding C [ Mus musculus (house mouse) ]

    Gene ID: 54170, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rragcprovided by MGI
    Official Full Name
    Ras-related GTP binding Cprovided by MGI
    Primary source
    MGI:MGI:1858751
    See related
    Ensembl:ENSMUSG00000028646 AllianceGenome:MGI:1858751
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gtr2; RAGC; TIB929; YGR163W
    Summary
    Predicted to enable several functions, including GTPase binding activity; guanyl ribonucleotide binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; cellular response to amino acid stimulus; and regulation of TOR signaling. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosome and nucleus. Orthologous to human RRAGC (Ras related GTP binding C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 33.1), subcutaneous fat pad adult (RPKM 30.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.2; 4 57.42 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (123811226..123830790)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (123917433..123936997)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D130007C19 gene Neighboring gene predicted gene, 31309 Neighboring gene STARR-positive B cell enhancer ABC_E2120 Neighboring gene STARR-positive B cell enhancer ABC_E11255 Neighboring gene MYC binding protein Neighboring gene STARR-seq mESC enhancer starr_11317 Neighboring gene predicted gene, 40241 Neighboring gene STARR-seq mESC enhancer starr_11320 Neighboring gene STARR-seq mESC enhancer starr_11321 Neighboring gene STARR-seq mESC enhancer starr_11322 Neighboring gene STARR-positive B cell enhancer mm9_chr4:123832926-123833227 Neighboring gene predicted gene, 40242

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A new member of the GTPase superfamily that is upregulated in highly metastatic cells. Nakaji T, et al. Cancer Lett, 1999 Dec 1. PMID 10660099
    2. Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs. Ortega-Molina A, et al. Cell Rep, 2021 Jul 13. PMID 34260908, Free PMC Article
    3. Oncogenic Rag GTPase signaling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR. Ortega-Molina A, et al. Nat Metab, 2019 Aug. PMID 31579886, Free PMC Article
    4. TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism. Alesi N, et al. Nat Commun, 2021 Jul 12. PMID 34253722, Free PMC Article
    5. Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine. Hong-Brown LQ, et al. Am J Physiol Cell Physiol, 2012 May 15. PMID 22442136, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism.
      Title: TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism.
    2. The constitutively active RagA-RagC heterodimer blocks the inhibitory effect of alcohol (EtOH).
      Title: Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC47404

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-membrane adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to amino acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of FNIP-folliculin RagC/D GAP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Gtr1-Gtr2 GTPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras-related GTP-binding protein C
    Names
    GTPase-interacting protein 2
    rag C
    small GTPase, homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017475.2 → NP_059503.2  ras-related GTP-binding protein C

      See identical proteins and their annotated locations for NP_059503.2

      Status: VALIDATED

      Source sequence(s)
      AK159355, AL606962, BE628749, CJ172014
      Consensus CDS
      CCDS18622.1
      UniProtKB/Swiss-Prot
      A2A7K7, Q3TL69, Q6IQZ6, Q8CFT7, Q99K70, Q9Z124
      Related
      ENSMUSP00000030399.7, ENSMUST00000030399.7
      Conserved Domains (1) summary
      cd11385
      Location:62 → 236
      RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      123811226..123830790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99K70.1 GenPept UniProtKB/Swiss-Prot:Q99K70

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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