U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 [ Mus musculus (house mouse) ]

    Gene ID: 21941, updated on 21-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tnfrsf8provided by MGI
    Official Full Name
    tumor necrosis factor receptor superfamily, member 8provided by MGI
    Primary source
    MGI:MGI:99908
    See related
    Ensembl:ENSMUSG00000028602 AllianceGenome:MGI:99908
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ki; Cd30; Ki-1; D1S166E
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in positive regulation of NF-kappaB transcription factor activity; positive regulation of apoptotic process; and positive regulation of tumor necrosis factor superfamily cytokine production. Predicted to be located in plasma membrane. Is expressed in several structures, including adrenal gland; brain; female reproductive system; intestine; and thymus. Orthologous to human TNFRSF8 (TNF receptor superfamily member 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thymus adult (RPKM 4.6), testis adult (RPKM 0.6) and 4 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    4 E1; 4 78.17 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (144993702..145041734, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (145267132..145315164, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor receptor superfamily, member 1b Neighboring gene STARR-positive B cell enhancer ABC_E11265 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:144832691-144832800 Neighboring gene STARR-positive B cell enhancer ABC_E8008 Neighboring gene predicted gene, 36233 Neighboring gene STARR-seq mESC enhancer starr_12014 Neighboring gene STARR-seq mESC enhancer starr_12016 Neighboring gene STARR-positive B cell enhancer mm9_chr4:144885570-144885871 Neighboring gene STARR-positive B cell enhancer ABC_E1663 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:144909212-144909413 Neighboring gene STARR-seq mESC enhancer starr_12020 Neighboring gene STARR-positive B cell enhancer ABC_E9608 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:144957328-144957437 Neighboring gene STARR-seq mESC enhancer starr_12022 Neighboring gene STARR-positive B cell enhancer mm9_chr4:144995732-144996033 Neighboring gene high mobility group box 2 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr4:144997421-144997722 Neighboring gene STARR-seq mESC enhancer starr_12024 Neighboring gene predicted gene, 42346 Neighboring gene STARR-seq mESC enhancer starr_12025 Neighboring gene STARR-positive B cell enhancer ABC_E9609 Neighboring gene STARR-positive B cell enhancer ABC_E2132 Neighboring gene STARR-positive B cell enhancer mm9_chr4:145039173-145039474 Neighboring gene STARR-positive B cell enhancer mm9_chr4:145043961-145044261

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Chronic CD30 signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells. Sperling S, et al. Blood, 2019 Jun 13. PMID 30962205
    2. Requirement of CD30 expression on CD4 T cells in the pathogenesis of experimental autoimmune encephalomyelitis. Shinoda K, et al. J Neuroimmunol, 2016 Feb 15. PMID 26857493
    3. NK cells protect secondary lymphoid tissue from cytomegalovirus via a CD30-dependent mechanism. Bekiaris V, et al. Eur J Immunol, 2009 Oct. PMID 19731363
    4. CD30 is required for CCL21 expression and CD4 T cell recruitment in the absence of lymphotoxin signals. Bekiaris V, et al. J Immunol, 2009 Apr 15. PMID 19342654
    5. Delayed recruitment of lymphocytes into the lungs of CD30-deficient mice during aerogenic Mycobacterium avium infections. Flórido M, et al. Immunobiology, 2009. PMID 19250702

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD30 plays a role in T-dependent immune response and T cell proliferation.
      Title: CD30 plays a role in T-dependent immune response and T cell proliferation.
    2. CD30 co-stimulation drives differentiation of protective T cells during Mycobacterium tuberculosis infection.
      Title: CD30 co-stimulation drives differentiation of protective T cells during Mycobacterium tuberculosis infection.
    3. CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury.
      Title: CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury.
    4. Blockade of tumor necrosis factor superfamily members CD30 and OX40 abrogates disease activity in murine immune-mediated glomerulonephritis.
      Title: Blockade of tumor necrosis factor superfamily members CD30 and OX40 abrogates disease activity in murine immune-mediated glomerulonephritis.
    5. Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation.
      Title: Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation.
    6. CD30L/CD30 signaling regulates the formation of the tumor immune microenvironment and inhibits intestinal tumor development of colitis-associated colon cancer in mice.
      Title: CD30L/CD30 signaling regulates the formation of the tumor immune microenvironment and inhibits intestinal tumor development of colitis-associated colon cancer in mice.
    7. chronic CD30 signaling increases the risk of B-cell lymphomagenesis.
      Title: Chronic CD30 signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells.
    8. This study demonstrated the amelioration of MOG35-55 peptide-induced active EAE in CD30 KO mice. CD30 was expressed limitedly on CD4 T cells at the induction phase of experimental autoimmune encephalomyelitis.
      Title: Requirement of CD30 expression on CD4 T cells in the pathogenesis of experimental autoimmune encephalomyelitis.
    9. Data indicate that CD30L/CD30 axis plays a modulatory role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE).
      Title: CD30 ligand is a new therapeutic target for central nervous system autoimmunity.
    10. role in the maintenance and activation of IL-17A-producing gammadelta T cells
      Title: CD30L/CD30 is critical for maintenance of IL-17A-producing γδ T cells bearing Vγ6 in mucosa-associated tissues in mice.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of TRAIL production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tumor necrosis factor receptor superfamily member 8
    Names
    CD30L receptor
    lymphocyte activation antigen CD30

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009401.3 → NP_033427.1  tumor necrosis factor receptor superfamily member 8 precursor

      See identical proteins and their annotated locations for NP_033427.1

      Status: VALIDATED

      Source sequence(s)
      AL627099
      Consensus CDS
      CCDS18915.1
      UniProtKB/Swiss-Prot
      A1L3C9, Q60846
      Related
      ENSMUSP00000030339.7, ENSMUST00000030339.13
      Conserved Domains (1) summary
      cd13409
      Location:3 → 127
      TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      144993702..145041734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163966.1 → XP_036019859.1  tumor necrosis factor receptor superfamily member 8 isoform X1

      Conserved Domains (2) summary
      PTZ00449
      Location:117 → 274
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd13409
      Location:6 → 112
      TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60846.1 GenPept UniProtKB/Swiss-Prot:Q60846

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous