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    Pigo phosphatidylinositol glycan anchor biosynthesis, class O [ Mus musculus (house mouse) ]

    Gene ID: 56703, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Pigoprovided by MGI
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Oprovided by MGI
    Primary source
    MGI:MGI:1861452
    See related
    Ensembl:ENSMUSG00000028454 AllianceGenome:MGI:1861452
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PIG-O
    Summary
    Predicted to enable mannose-ethanolamine phosphotransferase activity. Involved in GPI anchor biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and skeleton. Orthologous to human PIGO (phosphatidylinositol glycan anchor biosynthesis class O). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 11.6), duodenum adult (RPKM 11.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 A5; 4 22.98 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43016964..43026369, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43017626..43027696, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10043 Neighboring gene STARR-positive B cell enhancer ABC_E46 Neighboring gene STARR-positive B cell enhancer ABC_E1029 Neighboring gene STARR-seq mESC enhancer starr_10044 Neighboring gene valosin containing protein Neighboring gene Fanconi anemia, complementation group G Neighboring gene STARR-positive B cell enhancer ABC_E6165 Neighboring gene STARR-positive B cell enhancer ABC_E1642 Neighboring gene STARR-positive B cell enhancer ABC_E9237 Neighboring gene stomatin (Epb7.2)-like 2 Neighboring gene atos homolog B Neighboring gene unc-13 homolog B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol. Hong Y, et al. J Biol Chem, 2000 Jul 7. PMID 10781593
    2. GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol. Shishioh N, et al. J Biol Chem, 2005 Mar 11. PMID 15632136
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ00350, mFLJ00350

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mannose-ethanolamine phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannose-ethanolamine phosphotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphotransferase activity, for other substituted phosphate groups TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GPI ethanolamine phosphate transferase 3
    Names
    phosphatidylinositol-glycan biosynthesis class O protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305386.2 → NP_001292315.1  GPI ethanolamine phosphate transferase 3 isoform 2

      See identical proteins and their annotated locations for NP_001292315.1

      Status: VALIDATED

      Source sequence(s)
      AL672276
      UniProtKB/Swiss-Prot
      Q9CRY2, Q9JJI6
      Conserved Domains (1) summary
      cd16023
      Location:64 → 344
      GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O

    2. NM_001305387.2 → NP_001292316.1  GPI ethanolamine phosphate transferase 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL672276
      Consensus CDS
      CCDS84720.1
      UniProtKB/Swiss-Prot
      Q9CRY2, Q9JJI6
      UniProtKB/TrEMBL
      A2AG36
      Related
      ENSMUSP00000069749.6, ENSMUST00000067481.6
      Conserved Domains (2) summary
      COG1524
      Location:42 → 433
      Npp1; Predicted pyrophosphatase or phosphodiesterase, AlkP superfamily [General function prediction only]
      cd16023
      Location:64 → 344
      GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O

    3. NM_001423488.1 → NP_001410417.1  GPI ethanolamine phosphate transferase 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672276

    4. NM_020035.4 → NP_064419.3  GPI ethanolamine phosphate transferase 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672276
      Consensus CDS
      CCDS18088.1
      Related
      ENSMUSP00000095713.3, ENSMUST00000098109.9

    RNA

    1. NR_186838.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL672276

    2. NR_186839.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL672276

    3. NR_186840.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL672276

    4. NR_186841.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL672276

    5. NR_186842.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL672276

    6. NR_186843.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL672276

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      43016964..43026369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253685.2 → XP_030109545.1  GPI ethanolamine phosphate transferase 3 isoform X2

      Conserved Domains (1) summary
      cl23718
      Location:1 → 65
      ALP_like; alkaline phosphatases and sulfatases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJI6.2 GenPept UniProtKB/Swiss-Prot:Q9JJI6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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