Dkk2 dickkopf WNT signaling pathway inhibitor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dkk2provided by MGI
Official Full Name: dickkopf WNT signaling pathway inhibitor 2provided by MGI
Primary source: MGI:MGI:1890663
See related: Ensembl:ENSMUSG00000028031 AllianceGenome:MGI:1890663
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables co-receptor binding activity. Involved in negative regulation of Wnt signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; eye; and genitourinary system. Orthologous to human DKK2 (dickkopf WNT signaling pathway inhibitor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in limb E14.5 (RPKM 20.3), bladder adult (RPKM 10.5) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 61.32 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (131791027..131886065)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (132085266..132180304)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mesenchymal Stem Cell-Derived Extracellular Vesicles Inhibit Osteoporosis via MicroRNA-27a-Induced Inhibition of DKK2-Mediated Wnt/beta-Catenin Pathway.
Title: Mesenchymal Stem Cell-Derived Extracellular Vesicles Inhibit Osteoporosis via MicroRNA-27a-Induced Inhibition of DKK2-Mediated Wnt/β-Catenin Pathway.
Dickkopf-2 knockdown protects against classic macrophage polarization and lipid loading by activation of Wnt/beta-catenin signaling.
Title: Dickkopf-2 knockdown protects against classic macrophage polarization and lipid loading by activation of Wnt/β-catenin signaling.
Dickkopf (Dkk)-2 is a beige fat-enriched adipokine to regulate adipogenesis.
Title: Dickkopf (Dkk)-2 is a beige fat-enriched adipokine to regulate adipogenesis.
In the absence of Dkk2, Wnt/beta-catenin signaling activity is initially broadly elevated in embryonic plantar skin and gradually becomes patterned, mimicking follicular development in normally haired areas.
Title: Regional Control of Hairless versus Hair-Bearing Skin by Dkk2.
Reprogramming of damaged erectile tissue toward neurovascular repair by use of a DKK2 therapeutic protein may represent viable treatment option for this condition.
Title: Dickkopf2 rescues erectile function by enhancing penile neurovascular regeneration in a mouse model of cavernous nerve injury.
Data (including data from studies in transgenic mice) suggest that Dkk2 secreted from pericytes promotes angiogenesis and neurogenesis/neural regeneration via Angpt1/Tie2/Wnt signaling; here, overexpression of Dkk2 in diabetic mice enhances penile angiogenesis/neural regeneration and restores erectile function. (Dkk2 = dickkopf-2; Angpt1= angiopoietin-1; Tie2 = endothelial-specific receptor tyrosine kinase Tie2)
Title: Pericyte-Derived Dickkopf2 Regenerates Damaged Penile Neurovasculature Through an Angiopoietin-1-Tie2 Pathway.
Dkk2 deletion results in alterations of liver morphology leading to an increased frequency of liver cancer
Title: Increased liver carcinogenesis and enrichment of stem cell properties in livers of Dickkopf 2 (Dkk2) deleted mice.
Spermatogenesis-associated protein 3 (Spata3) and dickkopf-related protein 2 (Dkk2) were confirmed to interact with MIC3. The tandem repeat EGF domains of MIC3 were critical in mediating the interactions with the identified host proteins. The results show that MIC3 interacts with host proteins that are involved in reproduction, growth, and development.
Title: Identification of host proteins, Spata3 and Dkk2, interacting with Toxoplasma gondii micronemal protein MIC3.
these data reveal a novel mechanism that the Bmp4-Msx1 pathway and Osr2 control tooth organogenesis through antagonistic regulation of expression of secreted Wnt antagonists.
Title: Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists.
These findings demonstrate that DKK1 and DKK2 have differential roles in normalization and functionality of tumor blood vessels, in addition to angiogenesis.
Title: Distinct roles of DKK1 and DKK2 in tumor angiogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (5)

General gene information

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Markers

Dkk2 (e-PCR), detects polymorphism
- UniSTS:471822

Dkk2 (e-PCR), detects polymorphism
- UniSTS:508431

Dkk2 (e-PCR), detects polymorphism
- UniSTS:508432

Dkk2 (e-PCR), detects polymorphism
- UniSTS:527121

D3Nds2 (e-PCR), detects polymorphism
- UniSTS:142403

D3Nds3 (e-PCR), detects polymorphism
- UniSTS:142406

Dkk2 (e-PCR), detects polymorphism
- UniSTS:472902

Dkk2 (e-PCR), detects polymorphism
- UniSTS:277878

NoName (e-PCR)
- UniSTS:548470

Dkk2 (e-PCR), detects polymorphism
- UniSTS:528042

Dkk2 (e-PCR), detects polymorphism
- UniSTS:506848

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables co-receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables co-receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor antagonist activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dickkopf-related protein 2

Names: dickkopf 2; dickkopf homolog 1; dickkopf homolog 2; dkk-2; mDkk-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020265.4 → NP_064661.2 dickkopf-related protein 2 precursor

See identical proteins and their annotated locations for NP_064661.2

Status: VALIDATED

Source sequence(s)

AC127260

Consensus CDS

CCDS17844.1

UniProtKB/Swiss-Prot

Q8BFW0, Q9QYZ8

Related

ENSMUSP00000029665.6, ENSMUST00000029665.7

Conserved Domains (1) summary

pfam04706
Location:78 → 128

Dickkopf_N; Dickkopf N-terminal cysteine-rich region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

131791027..131886065

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501818.5 → XP_006501881.1 dickkopf-related protein 2 isoform X1

Conserved Domains (1) summary

pfam04706
Location:91 → 141

Dickkopf_N; Dickkopf N-terminal cysteine-rich region