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    Zbp1 Z-DNA binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 58203, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Zbp1provided by MGI
    Official Full Name
    Z-DNA binding protein 1provided by MGI
    Primary source
    MGI:MGI:1927449
    See related
    Ensembl:ENSMUSG00000027514 AllianceGenome:MGI:1927449
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dai; Dlm1; mZaDLM; 2010010H03Rik
    Summary
    Enables double-stranded RNA binding activity and left-handed Z-DNA binding activity. Involved in several processes, including positive regulation of defense response; positive regulation of programmed cell death; and regulation of interleukin-1-mediated signaling pathway. Acts upstream of or within positive regulation of type I interferon-mediated signaling pathway. Located in cytoplasm and nucleus. Is expressed in eye and heart. Orthologous to human ZBP1 (Z-DNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 22.2), thymus adult (RPKM 15.0) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H3; 2 95.83 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (173048405..173060715, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (173206612..173218959, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06610 Neighboring gene predicted gene, 36691 Neighboring gene predicted gene, 36749 Neighboring gene STARR-positive B cell enhancer ABC_E9076 Neighboring gene phosphoenolpyruvate carboxykinase 1, cytosolic Neighboring gene STARR-seq mESC enhancer starr_06613 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:173055154-173055337 Neighboring gene prostate transmembrane protein, androgen induced 1 Neighboring gene STARR-seq mESC enhancer starr_06615 Neighboring gene prostate transmembrane protein, androgen induced 1, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibition of DAI refrains dendritic cells from maturation and prolongs murine islet and skin allograft survival. Cheng P, et al. Front Immunol, 2023. PMID 37197662, Free PMC Article
    2. ZBP1 Protects Against mtDNA-Induced Myocardial Inflammation in Failing Hearts. Enzan N, et al. Circ Res, 2023 Apr 28. PMID 36974722, Free PMC Article
    3. ZBP1 promotes inflammatory responses downstream of TLR3/TLR4 via timely delivery of RIPK1 to TRIF. Muendlein HI, et al. Proc Natl Acad Sci U S A, 2022 Jun 14. PMID 35666872, Free PMC Article
    4. Z-DNA binding protein 1 mediates necroptotic and apoptotic cell death pathways in murine astrocytes following herpes simplex virus-1 infection. Jeffries AM, et al. J Neuroinflammation, 2022 May 13. PMID 35549723, Free PMC Article
    5. Zbp1-positive cells are osteogenic progenitors in periodontal ligament. Ueda T, et al. Sci Rep, 2021 Apr 6. PMID 33824390, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZBP1 activation triggers hematopoietic stem and progenitor cell death resulting in bone marrow failure in mice.
      Title: ZBP1 activation triggers hematopoietic stem and progenitor cell death resulting in bone marrow failure in mice.
    2. Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and NLRP12-PANoptosome activation and inflammatory cell death (PANoptosis).
      Title: Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and NLRP12-PANoptosome activation and inflammatory cell death (PANoptosis).
    3. Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
      Title: Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
    4. Inhibition of DAI refrains dendritic cells from maturation and prolongs murine islet and skin allograft survival.
      Title: Inhibition of DAI refrains dendritic cells from maturation and prolongs murine islet and skin allograft survival.
    5. ZBP1 Protects Against mtDNA-Induced Myocardial Inflammation in Failing Hearts.
      Title: ZBP1 Protects Against mtDNA-Induced Myocardial Inflammation in Failing Hearts.
    6. SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses.
      Title: SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses.
    7. Differential transcriptomic changes in the central nervous system and urinary bladders of mice infected with a coronavirus.
      Title: Differential transcriptomic changes in the central nervous system and urinary bladders of mice infected with a coronavirus.
    8. Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis.
      Title: Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis.
    9. ADAR1 averts fatal type I interferon induction by ZBP1.
      Title: ADAR1 averts fatal type I interferon induction by ZBP1.
    10. ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis.
      Title: ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis.
    Submit: New GeneRIF Correction See all GeneRIFs (44)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded RNA adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables left-handed Z-DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in activation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of necroptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of necroptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of necroptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of type I interferon-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within programmed cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyroptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of interleukin-1-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Z-DNA-binding protein 1
    Names
    DNA-dependent activator of IFN-regulatory factors
    tumor stroma and activated macrophage protein DLM-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001139519.1 → NP_001132991.1  Z-DNA-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001132991.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and has multiple differences in the 3' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK008179, BY170802
      Consensus CDS
      CCDS50813.1
      UniProtKB/Swiss-Prot
      Q9QY24
      Related
      ENSMUSP00000104744.3, ENSMUST00000109116.3
      Conserved Domains (1) summary
      cl02659
      Location:8 → 72
      z-alpha; Adenosine deaminase z-alpha domain

    2. NM_021394.2 → NP_067369.2  Z-DNA-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_067369.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI643886, AL837509, AX775969, BY170802
      Consensus CDS
      CCDS17142.1
      UniProtKB/Swiss-Prot
      Q8VE02, Q9D8B9, Q9QY24
      UniProtKB/TrEMBL
      A2APF7
      Related
      ENSMUSP00000029018.8, ENSMUST00000029018.14
      Conserved Domains (2) summary
      smart00550
      Location:8 → 72
      Zalpha; Z-DNA-binding domain in adenosine deaminases
      cl02659
      Location:84 → 147
      z-alpha; Adenosine deaminase z-alpha domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      173048405..173060715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QY24.1 GenPept UniProtKB/Swiss-Prot:Q9QY24

    Gene LinkOut

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