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    Rrbp1 ribosome binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 81910, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rrbp1provided by MGI
    Official Full Name
    ribosome binding protein 1provided by MGI
    Primary source
    MGI:MGI:1932395
    See related
    Ensembl:ENSMUSG00000027422 AllianceGenome:MGI:1932395
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p180; mRRp0; mRRp2; ES/130; mRRp10; mRRp41; mRRp47; mRRp1.8; mRRp15a; mRRp15b; mRRp5.4; mRRp16.8; mKIAA1398; 1700087N07Rik; 5730465C04Rik
    Summary
    Predicted to act upstream of or within protein transport. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in embryo. Orthologous to human RRBP1 (ribosome binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 37.3), liver E18 (RPKM 30.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 G1; 2 70.89 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (143789315..143853216, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (143947395..144011296, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene beaded filament structural protein 1, in lens-CP94 Neighboring gene predicted gene 11686 Neighboring gene STARR-seq mESC enhancer starr_05893 Neighboring gene STARR-positive B cell enhancer ABC_E9072 Neighboring gene STARR-seq mESC enhancer starr_05895 Neighboring gene destrin Neighboring gene predicted gene, 33804 Neighboring gene predicted gene, 54119 Neighboring gene STARR-seq mESC enhancer starr_05899 Neighboring gene STARR-positive B cell enhancer ABC_E513 Neighboring gene STARR-positive B cell enhancer ABC_E2050 Neighboring gene STARR-seq mESC enhancer starr_05901 Neighboring gene BANF family member 2 Neighboring gene barrier to autointegration factor 2, opposite strand Neighboring gene STARR-positive B cell enhancer mm9_chr2:143918460-143918761 Neighboring gene predicted gene, 53188

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of multiple isoforms of a mouse ribosome receptor. Kim YJ, et al. Gene, 2000 Dec 31. PMID 11167022
    2. Mitochondria-ER cooperation: NLRX1 detects mitochondrial protein import stress and promotes mitophagy through the ER protein RRBP1. Killackey SA, et al. Autophagy, 2023 May. PMID 36170592, Free PMC Article
    3. Genetic analysis of albuminuria in a cross between C57BL/6J and DBA/2J mice. Sheehan S, et al. Am J Physiol Renal Physiol, 2007 Nov. PMID 17804484
    4. Identification of positional candidate genes for body weight and adiposity in subcongenic mice. Chiu S, et al. Physiol Genomics, 2007 Sep 19. PMID 17536020
    5. RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Lo JC, et al. PLoS Genet, 2012. PMID 23055941, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mitochondria-ER cooperation: NLRX1 detects mitochondrial protein import stress and promotes mitophagy through the ER protein RRBP1.
      Title: Mitochondria-ER cooperation: NLRX1 detects mitochondrial protein import stress and promotes mitophagy through the ER protein RRBP1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosome-binding protein 1
    Names
    RRp
    mRRp
    ribosome receptor protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024281.2 → NP_077243.2  ribosome-binding protein 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AK019964, AK039114, AL929550, BE943663, CK787870, W75337
      Consensus CDS
      CCDS38252.1
      UniProtKB/Swiss-Prot
      A2AVJ8, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q99PL5, Q9CS20
      UniProtKB/TrEMBL
      A2AVJ7
      Related
      ENSMUSP00000016072.6, ENSMUST00000016072.12
      Conserved Domains (4) summary
      PRK02224
      Location:968 → 1448
      PRK02224; chromosome segregation protein; Provisional
      pfam00261
      Location:833 → 1081
      Tropomyosin; Tropomyosin
      pfam05104
      Location:33 → 171
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
      cl02488
      Location:877 → 1071
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    2. NM_133626.2 → NP_598329.1  ribosome-binding protein 1 isoform b

      See identical proteins and their annotated locations for NP_598329.1

      Status: VALIDATED

      Source sequence(s)
      AK039114, AL929550, BQ033142
      Consensus CDS
      CCDS38253.1
      UniProtKB/Swiss-Prot
      Q99PL5
      UniProtKB/TrEMBL
      Q8CAB9
      Related
      ENSMUSP00000040560.6, ENSMUST00000037875.6
      Conserved Domains (1) summary
      pfam05104
      Location:33 → 171
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      143789315..143853216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500441.2 → XP_006500504.1  ribosome-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      Q6ZPS0
      Conserved Domains (1) summary
      TIGR02168
      Location:155 → 857
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_006500440.2 → XP_006500503.1  ribosome-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A2AVJ8, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q99PL5, Q9CS20
      Conserved Domains (3) summary
      TIGR00927
      Location:260 → 513
      2A1904; K+-dependent Na+/Ca+ exchanger
      TIGR02168
      Location:760 → 1430
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05104
      Location:33 → 168
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    3. XM_006500443.1 → XP_006500506.1  ribosome-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      Q6ZPS0
      Conserved Domains (1) summary
      TIGR02168
      Location:111 → 813
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. XM_006500444.5 → XP_006500507.1  ribosome-binding protein 1 isoform X5

      UniProtKB/TrEMBL
      Q6ZPS0
      Conserved Domains (1) summary
      TIGR02168
      Location:63 → 765
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. XM_036162731.1 → XP_036018624.1  ribosome-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      Q6ZPS0
      Conserved Domains (1) summary
      TIGR02168
      Location:203 → 847
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99PL5.2 GenPept UniProtKB/Swiss-Prot:Q99PL5

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