Bcl2l11 BCL2 like 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bcl2l11provided by MGI
Official Full Name: BCL2 like 11provided by MGI
Primary source: MGI:MGI:1197519
See related: Ensembl:ENSMUSG00000027381 AllianceGenome:MGI:1197519
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bim; Bod; bcl2-L-11; 1500006F24Rik
Summary: Enables dynein complex binding activity; microtubule binding activity; and protein kinase binding activity. Involved in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including animal organ development; apoptotic signaling pathway; and lymphocyte homeostasis. Located in mitochondrion. Is extrinsic component of membrane. Part of Bcl-2 family protein complex. Is expressed in brain; hair outer root sheath; metanephros; spleen; and trunk unsegmented mesenchyme. Orthologous to human BCL2L11 (BCL2 like 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 7.8), lung adult (RPKM 4.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 62.23 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (127967958..128004467)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (128126038..128162547)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

circ_0000018 downregulation peripherally ameliorates neuroprotection against acute ischemic stroke through the miR-871/BCL2L11 axis.
Title: circ_0000018 downregulation peripherally ameliorates neuroprotection against acute ischemic stroke through the miR‑871/BCL2L11 axis.
Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity.
Title: Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity.
MNT suppresses T cell apoptosis via BIM and is critical for T lymphomagenesis.
Title: MNT suppresses T cell apoptosis via BIM and is critical for T lymphomagenesis.
Bim Deletion Reduces Functional Deficits Following Ischemic Stroke in Association with Modulation of Apoptosis and Inflammation.
Title: Bim Deletion Reduces Functional Deficits Following Ischemic Stroke in Association with Modulation of Apoptosis and Inflammation.
Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced Obesity in Mice.
Title: Nova1 or Bim Deficiency in Pancreatic β-Cells Does Not Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced Obesity in Mice.
Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation.
Title: Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation.
Absence of Bim sensitizes mice to experimental Trypanosoma cruzi infection.
Title: Absence of Bim sensitizes mice to experimental Trypanosoma cruzi infection.
Suppression of Sox4 protects against myocardial ischemic injury by reduction of cardiac apoptosis in mice.
Title: Suppression of Sox4 protects against myocardial ischemic injury by reduction of cardiac apoptosis in mice.
miR17~92 restrains pro-apoptotic BIM to ensure survival of haematopoietic stem and progenitor cells.
Title: miR17~92 restrains pro-apoptotic BIM to ensure survival of haematopoietic stem and progenitor cells.
T-cell receptor signal strength and epigenetic control of Bim predict memory CD8(+) T-cell fate.
Title: T-cell receptor signal strength and epigenetic control of Bim predict memory CD8(+) T-cell fate.

Submit: New GeneRIF Correction See all GeneRIFs (239)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (19) 1 citation
Endonuclease-mediated (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB257531 (e-PCR)
- UniSTS:207396

RH131553 (e-PCR)
- UniSTS:214836

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to microtubule binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within B cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of T cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within T cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process involved in embryonic digit morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within developmental pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ear development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within kidney development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within leukocyte homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within leukocyte homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of lymphocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymphocyte homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lymphocyte homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male gonad development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mammary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiosis I	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myeloid cell homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of T cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of T cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy in response to ER overload	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of lymphocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of mitochondrial membrane permeability involved in apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of developmental pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within spleen development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within symbiont-mediated activation of host apoptosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within thymocyte apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within thymus development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within tube formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of BIM-BCL-2 complex	ISO Inferred from Sequence Orthology more info
part_of BIM-BCL-xl complex	ISO Inferred from Sequence Orthology more info
part_of Bcl-2 family protein complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of Bcl-2 family protein complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with microtubule	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: bcl-2-like protein 11

Names: BCL2-like 11 (apoptosis facilitator); Bcl2 interacting mediator of cell death; bcl2-interacting mediator of cell death

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001284410.3 → NP_001271339.2 bcl-2-like protein 11 isoform 4

Status: VALIDATED

Source sequence(s)

AL805950

UniProtKB/TrEMBL

Q6PEB3
NM_001291016.1 → NP_001277945.1 bcl-2-like protein 11 isoform 4

See identical proteins and their annotated locations for NP_001277945.1

Status: VALIDATED

Source sequence(s)

AK037885, AK162975

Consensus CDS

CCDS71141.1

UniProtKB/TrEMBL

Q6PEB3

Related

ENSMUSP00000087062.6, ENSMUST00000089634.12

Conserved Domains (1) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus
NM_001406057.1 → NP_001392986.1 bcl-2-like protein 11 isoform 2

Status: VALIDATED

Source sequence(s)

AL805950
NM_001406058.1 → NP_001392987.1 bcl-2-like protein 11 isoform 3

Status: VALIDATED

Source sequence(s)

AL805950

UniProtKB/TrEMBL

Q3U7X3
NM_001406059.1 → NP_001392988.1 bcl-2-like protein 11 isoform 6

Status: VALIDATED

Source sequence(s)

AL805950
NM_001406060.1 → NP_001392989.1 bcl-2-like protein 11 isoform 6

Status: VALIDATED

Source sequence(s)

AL805950
NM_001406061.1 → NP_001392990.1 bcl-2-like protein 11 isoform 7

Status: VALIDATED

Source sequence(s)

AL805950
NM_009754.3 → NP_033884.1 bcl-2-like protein 11 isoform 3

See identical proteins and their annotated locations for NP_033884.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.

Source sequence(s)

AA881651, AF032461, AK037885, AK082613, BE136124, CA321725, CB521709

Consensus CDS

CCDS16712.1

UniProtKB/TrEMBL

Q3U7X3

Related

ENSMUSP00000099500.2, ENSMUST00000103211.8

Conserved Domains (2) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus

pfam08945
Location:42 → 76

Bclx_interact; Bcl-x interacting, BH3 domain
NM_207680.2 → NP_997563.1 bcl-2-like protein 11 isoform 1

See identical proteins and their annotated locations for NP_997563.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AA881651, AK037885, AK082613, BE136124, CA321725, CB521709

Consensus CDS

CCDS16713.1

UniProtKB/Swiss-Prot

A2ALQ6, O54918, O54919, O54920

UniProtKB/TrEMBL

Q542N5

Related

ENSMUSP00000105970.3, ENSMUST00000110341.9

Conserved Domains (2) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus

pfam08945
Location:128 → 164

Bclx_interact; Bcl-x interacting, BH3 domain
NM_207681.2 → NP_997564.1 bcl-2-like protein 11 isoform 2

See identical proteins and their annotated locations for NP_997564.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.

Source sequence(s)

AA881651, AK037885, AK050192, AK082613, BE136124, CA321725, CB521709

Consensus CDS

CCDS16714.1

UniProtKB/Swiss-Prot

O54918

UniProtKB/TrEMBL

Q542N5

Related

ENSMUSP00000099499.2, ENSMUST00000103210.2

Conserved Domains (2) summary

pfam06773
Location:4 → 40

Bim_N; Bim protein N-terminus

pfam08945
Location:72 → 106

Bclx_interact; Bcl-x interacting, BH3 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

127967958..128004467

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498614.4 → XP_006498677.1 bcl-2-like protein 11 isoform X1

Conserved Domains (2) summary

pfam06773
Location:78 → 114

Bim_N; Bim protein N-terminus

pfam08945
Location:202 → 236

Bclx_interact; Bcl-x interacting, BH3 domain
XM_006498615.4 → XP_006498678.1 bcl-2-like protein 11 isoform X2

Conserved Domains (1) summary

pfam06773
Location:78 → 114

Bim_N; Bim protein N-terminus