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    Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 [ Mus musculus (house mouse) ]

    Gene ID: 59029, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Psmd14provided by MGI
    Official Full Name
    proteasome (prosome, macropain) 26S subunit, non-ATPase, 14provided by MGI
    Primary source
    MGI:MGI:1913284
    See related
    Ensembl:ENSMUSG00000026914 AllianceGenome:MGI:1913284
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pad1; Poh1; rpm11; 2610312C03Rik; 3200001M20Rik
    Summary
    Predicted to enable endopeptidase activator activity; peptidase activity; and proteasome binding activity. Predicted to be involved in double-strand break repair; proteolysis; and regulation of proteasomal protein catabolic process. Predicted to act upstream of or within DNA repair and proteolysis. Part of proteasome accessory complex. Is expressed in genitourinary system. Orthologous to human PSMD14 (proteasome 26S subunit, non-ATPase 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 35.4), liver E14 (RPKM 33.6) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 C1.3; 2 35.56 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (61542038..61630720)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (61711694..61800376)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 33841 Neighboring gene STARR-seq mESC enhancer starr_04631 Neighboring gene STARR-positive B cell enhancer ABC_E808 Neighboring gene STARR-positive B cell enhancer ABC_E5924 Neighboring gene STARR-positive B cell enhancer ABC_E506 Neighboring gene STARR-positive B cell enhancer ABC_E7821 Neighboring gene TRAF family member-associated Nf-kappa B activator Neighboring gene STARR-positive B cell enhancer mm9_chr2:61481154-61481454 Neighboring gene STARR-seq mESC enhancer starr_04632 Neighboring gene STARR-positive B cell enhancer ABC_E4457 Neighboring gene T-box brain transcription factor 1 Neighboring gene STARR-seq mESC enhancer starr_04635 Neighboring gene predicted gene, 39837

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Specific Modification of Aged Proteasomes Revealed by Tag-Exchangeable Knock-In Mice. Tomita T, et al. Mol Cell Biol, 2019 Jan 1. PMID 30348842, Free PMC Article
    2. An Arsenite Relay between PSMD14 and AIRAP Enables Revival of Proteasomal DUB Activity. Sukenik S, et al. Biomolecules, 2021 Sep 6. PMID 34572530, Free PMC Article
    3. POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity. Zhang L, et al. Nat Commun, 2018 Oct 12. PMID 30315153, Free PMC Article
    4. Requirement for POH1 in differentiation and maintenance of regulatory T cells. Liu Y, et al. Cell Death Differ, 2019 Mar. PMID 30038387, Free PMC Article
    5. POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation. Wang B, et al. Nat Commun, 2015 Oct 29. PMID 26510456, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An Arsenite Relay between PSMD14 and AIRAP Enables Revival of Proteasomal DUB Activity.
      Title: An Arsenite Relay between PSMD14 and AIRAP Enables Revival of Proteasomal DUB Activity.
    2. T cell-specific deletion of the gene encoding the deubiquitinase POH1 compromised the development of mature T cells, especially CD4(+)Foxp3(+) Treg cells. Moreover, POH1 deficiency significantly attenuated the transition of CD25(+) Treg cell precursors into Foxp3(+) Treg cells accompanied by downregulation of interleukin 2 (IL-2)-STAT5 signaling.
      Title: Requirement for POH1 in differentiation and maintenance of regulatory T cells.
    3. Study thereby reveals that POH1-mediated deubiquitination of pro-IL-1beta is an important regulatory event that restrains inflammatory responses for the maintenance of immune homeostasis.
      Title: POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity.
    4. Conditional knockout of Poh1 alleles results in reduced E2F1 expression in primary mouse liver cells.
      Title: POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation.
    5. These results identify a novel mechanism of Mitf regulation in osteoclasts by POH1.
      Title: The 19S proteasomal lid subunit POH1 enhances the transcriptional activation by Mitf in osteoclasts.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal-dependent deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal-dependent deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteasome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome accessory complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of proteasome regulatory particle, lid subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome regulatory particle, lid subcomplex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    26S proteasome non-ATPase regulatory subunit 14
    Names
    26S proteasome non-ATPase subunit
    26S proteasome regulatory subunit rpn11
    26S proteasome-associated pad1 homolog
    MAD1
    proteasome 26S subunit, non-ATPase 14
    NP_067501.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021526.2 → NP_067501.2  26S proteasome non-ATPase regulatory subunit 14

      See identical proteins and their annotated locations for NP_067501.2

      Status: VALIDATED

      Source sequence(s)
      AI448878, AK012013, BY324928
      Consensus CDS
      CCDS38127.1
      UniProtKB/Swiss-Prot
      O35593, Q3UB50, Q9CZY6
      UniProtKB/TrEMBL
      Q3UD26
      Related
      ENSMUSP00000028278.8, ENSMUST00000028278.14
      Conserved Domains (1) summary
      cd08069
      Location:21 → 286
      MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      61542038..61630720
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35593.2 GenPept UniProtKB/Swiss-Prot:O35593

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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