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    Kif26b kinesin family member 26B [ Mus musculus (house mouse) ]

    Gene ID: 269152, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Kif26bprovided by MGI
    Official Full Name
    kinesin family member 26Bprovided by MGI
    Primary source
    MGI:MGI:2447076
    See related
    Ensembl:ENSMUSG00000026494 AllianceGenome:MGI:2447076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4832420M10; D230039L06Rik
    Summary
    Predicted to enable microtubule binding activity and microtubule motor activity. Acts upstream of or within establishment of cell polarity; positive regulation of cell-cell adhesion; and ureteric bud invasion. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hindlimb interdigital region; and sensory organ. Orthologous to human KIF26B (kinesin family member 26B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 3.6), CNS E18 (RPKM 3.1) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kif26b in Genome Data Viewer
    Location:
    1 H4; 1 83.16 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (178356690..178766765)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (178529125..178932857)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03154 Neighboring gene STARR-seq mESC enhancer starr_03155 Neighboring gene predicted gene, 31289 Neighboring gene predicted gene, 39709 Neighboring gene predicted gene, 24405 Neighboring gene STARR-seq mESC enhancer starr_03157 Neighboring gene STARR-seq mESC enhancer starr_03158 Neighboring gene coiled-coil domain-containing protein 121-like Neighboring gene STARR-seq mESC enhancer starr_03160 Neighboring gene SET and MYND domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_03161 Neighboring gene STARR-seq mESC enhancer starr_03163 Neighboring gene STARR-seq mESC enhancer starr_03164 Neighboring gene STARR-seq mESC enhancer starr_03166 Neighboring gene STARR-seq mESC enhancer starr_03168 Neighboring gene STARR-seq mESC enhancer starr_03170 Neighboring gene predicted gene, 31349 Neighboring gene STARR-seq mESC enhancer starr_03171 Neighboring gene STARR-seq mESC enhancer starr_03172 Neighboring gene STARR-positive B cell enhancer ABC_E10067 Neighboring gene STARR-positive B cell enhancer ABC_E3339 Neighboring gene STARR-positive B cell enhancer mm9_chr1:181437064-181437364 Neighboring gene STARR-positive B cell enhancer mm9_chr1:181447992-181448293 Neighboring gene ribosomal protein L29 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Kif26b contributes to the progression of interstitial fibrosis via migration and myofibroblast differentiation in renal fibroblast. Yamamura Y, et al. FASEB J, 2022 Nov. PMID 36250931
    2. Novel mechanistic role of Kif26b in adipogenic differentiation of murine multipotent stromal cells. Yan M, et al. Biochem Biophys Res Commun, 2022 Feb 12. PMID 35066304
    3. KIF26B Silencing Prevents Osseous Transdifferentiation of Progenitor/Stem Cells and Attenuates Ectopic Calcification in a Murine Model. Yan M, et al. J Bone Miner Res, 2022 Feb. PMID 34787331
    4. The postsynaptic density protein Abelson interactor protein 1 interacts with the motor protein Kinesin family member 26B in hippocampal neurons. Heinrich J, et al. Neuroscience, 2012 Sep 27. PMID 22766233
    5. Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity-signaling pathway. Guillabert-Gourgues A, et al. Mol Biol Cell, 2016 Mar 15. PMID 26792835, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kif26b contributes to the progression of interstitial fibrosis via migration and myofibroblast differentiation in renal fibroblast.
      Title: Kif26b contributes to the progression of interstitial fibrosis via migration and myofibroblast differentiation in renal fibroblast.
    2. KIF26B Silencing Prevents Osseous Transdifferentiation of Progenitor/Stem Cells and Attenuates Ectopic Calcification in a Murine Model.
      Title: KIF26B Silencing Prevents Osseous Transdifferentiation of Progenitor/Stem Cells and Attenuates Ectopic Calcification in a Murine Model.
    3. Novel mechanistic role of Kif26b in adipogenic differentiation of murine multipotent stromal cells.
      Title: Novel mechanistic role of Kif26b in adipogenic differentiation of murine multipotent stromal cells.
    4. Kif26b links Wnt5a-Ror signaling to the control of morphogenetic cell and tissue behaviors in vertebrates and reveal a new role for regulated proteolysis in noncanonical Wnt5a-Ror signal transduction.
      Title: Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates.
    5. Kif26b, together with Dvl3/Daam1, initiates cell polarity through the control of planar cell polarity-signaling pathway-dependent activation in endothelial cells.
      Title: Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity-signaling pathway.
    6. Kif26b degradation in the metanephric mesenchyme via the ubiquitin-proteasome pathway may be important for proper kidney development.
      Title: Phosphorylation of Kif26b promotes its polyubiquitination and subsequent proteasomal degradation during kidney development.
    7. Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme.
      Title: Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme.
    8. KIF26B may play a role in embryogenesis, specifically in the development of limbs, face, and somites
      Title: An enhancer-trap LacZ transgene reveals a distinct expression pattern of Kinesin family 26B in mouse embryos.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156028, MGC169313

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell-cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ureteric bud invasion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF26B
    Names
    N-11 kinesin
    kinesin family protein 26b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161665.1 → NP_001155137.1  kinesin-like protein KIF26B

      See identical proteins and their annotated locations for NP_001155137.1

      Status: VALIDATED

      Source sequence(s)
      AC140776, AK052046, BC068141, CD348243
      Consensus CDS
      CCDS48464.1
      UniProtKB/Swiss-Prot
      D5MP63, E9PXV6, Q0VB48, Q7TNC6, Q8BHX2, Q8BKH6
      Related
      ENSMUSP00000124462.2, ENSMUST00000161017.8
      Conserved Domains (2) summary
      smart00129
      Location:451 → 798
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00106
      Location:450 → 798
      KISc; Kinesin motor domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      178356690..178766765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496865.4 → XP_006496928.1  kinesin-like protein KIF26B isoform X1

      UniProtKB/TrEMBL
      E9PX64
      Related
      ENSMUSP00000124608.2, ENSMUST00000160789.2
      Conserved Domains (1) summary
      cd00106
      Location:68 → 416
      KISc; Kinesin motor domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177724.4: Suppressed sequence

      Description
      NM_177724.4: This RefSeq was permanently suppressed because the CDS was partial.

    2. NM_177757.3: Suppressed sequence

      Description
      NM_177757.3: This RefSeq was permanently suppressed because the CDS was partial.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TNC6.3 GenPept UniProtKB/Swiss-Prot:Q7TNC6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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