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    Slc45a3 solute carrier family 45, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 212980, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Slc45a3provided by MGI
    Official Full Name
    solute carrier family 45, member 3provided by MGI
    Primary source
    MGI:MGI:1922082
    See related
    Ensembl:ENSMUSG00000026435 AllianceGenome:MGI:1922082
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PRST; IPCA-6; Pcanap6; 2210413P12Rik
    Summary
    Enables sucrose:proton symporter activity. Involved in positive regulation of fatty acid biosynthetic process; positive regulation of glucose metabolic process; and regulation of oligodendrocyte differentiation. Acts upstream of or within sucrose transport. Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in several structures, including alimentary system; genitourinary system; liver and biliary system; nervous system; and sensory organ. Orthologous to human SLC45A3 (solute carrier family 45 member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in ovary adult (RPKM 64.4), stomach adult (RPKM 39.0) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc45a3 in Genome Data Viewer
    Location:
    1 E4; 1 57.24 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131890653..131910710)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131962915..131982972)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5799 Neighboring gene STARR-seq mESC enhancer starr_02227 Neighboring gene RAB29, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_02228 Neighboring gene STARR-seq mESC enhancer starr_02229 Neighboring gene nuclear casein kinase and cyclin-dependent kinase substrate 1 Neighboring gene STARR-positive B cell enhancer mm9_chr1:133879500-133879800 Neighboring gene STARR-positive B cell enhancer ABC_E5800 Neighboring gene STARR-positive B cell enhancer ABC_E5801 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133904735-133904947 Neighboring gene STARR-positive B cell enhancer ABC_E10036 Neighboring gene STARR-positive B cell enhancer ABC_E11086 Neighboring gene STARR-positive B cell enhancer ABC_E5802 Neighboring gene ELK4, member of ETS oncogene family Neighboring gene major facilitator superfamily domain containing 4A Neighboring gene RIKEN cDNA 4833413N01 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DNA microarray analysis of region-specific gene expression in the mouse epididymis. Hsia N, et al. Biol Reprod, 2004 Feb. PMID 14561649
    2. miR-32 and its target SLC45A3 regulate the lipid metabolism of oligodendrocytes and myelin. Shin D, et al. Neuroscience, 2012 Jun 28. PMID 22521588, Free PMC Article
    3. Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae. Bartölke R, et al. Biochem J, 2014 Dec 1. PMID 25164149
    4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC32471

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables sucrose:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sucrose:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sucrose transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 45 member 3
    Names
    Prostein
    prostate cancer-associated protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177628.2 → NP_001171099.1  solute carrier family 45 member 3

      See identical proteins and their annotated locations for NP_001171099.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC107837, AK035428, BY713333
      Consensus CDS
      CCDS15278.1
      UniProtKB/Swiss-Prot
      Q8K0H7, Q8K252, Q8R1I0
      Related
      ENSMUSP00000136190.2, ENSMUST00000177943.8
      Conserved Domains (1) summary
      cd17313
      Location:18 → 537
      MFS_SLC45_SUC; Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters

    2. NM_145977.2 → NP_666089.1  solute carrier family 45 member 3

      See identical proteins and their annotated locations for NP_666089.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC107837
      Consensus CDS
      CCDS15278.1
      UniProtKB/Swiss-Prot
      Q8K0H7, Q8K252, Q8R1I0
      Related
      ENSMUSP00000027695.7, ENSMUST00000027695.8
      Conserved Domains (1) summary
      cd17313
      Location:18 → 537
      MFS_SLC45_SUC; Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      131890653..131910710
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529341.3 → XP_006529404.1  solute carrier family 45 member 3 isoform X1

      See identical proteins and their annotated locations for XP_006529404.1

      UniProtKB/Swiss-Prot
      Q8K0H7, Q8K252, Q8R1I0
      Conserved Domains (1) summary
      cd17313
      Location:18 → 537
      MFS_SLC45_SUC; Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters

    2. XM_006529342.3 → XP_006529405.1  solute carrier family 45 member 3 isoform X1

      See identical proteins and their annotated locations for XP_006529405.1

      UniProtKB/Swiss-Prot
      Q8K0H7, Q8K252, Q8R1I0
      Conserved Domains (1) summary
      cd17313
      Location:18 → 537
      MFS_SLC45_SUC; Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K0H7.1 GenPept UniProtKB/Swiss-Prot:Q8K0H7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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