Steap3 STEAP family member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Steap3provided by MGI
Official Full Name: STEAP family member 3provided by MGI
Primary source: MGI:MGI:1915678
See related: Ensembl:ENSMUSG00000026389 AllianceGenome:MGI:1915678
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tsap6; pHyde; 1010001D01Rik
Summary: Enables cupric reductase activity and ferric-chelate reductase (NADPH) activity. Acts upstream of or within exosomal secretion; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and transition metal ion transport. Located in endosome and plasma membrane. Is expressed in several structures, including bone; genitourinary system; liver; nervous system; and white fat. Orthologous to human STEAP3 (STEAP3 metalloreductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 51.4), mammary gland adult (RPKM 39.1) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E2.3; 1 52.66 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (120154137..120198810, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (120226414..120271081, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

STEAP3 (Six-Transmembrane Epithelial Antigen of Prostate 3) Inhibits Pathological Cardiac Hypertrophy.
Title: STEAP3 (Six-Transmembrane Epithelial Antigen of Prostate 3) Inhibits Pathological Cardiac Hypertrophy.
Six-Transmembrane Epithelial Antigen of the Prostate 3 Deficiency in Hepatocytes Protects the Liver Against Ischemia-Reperfusion Injury by Suppressing Transforming Growth Factor-beta-Activated Kinase 1.
Title: Six-Transmembrane Epithelial Antigen of the Prostate 3 Deficiency in Hepatocytes Protects the Liver Against Ischemia-Reperfusion Injury by Suppressing Transforming Growth Factor-β-Activated Kinase 1.
TSAP6 deficiency results in abnormal erythroid maturation and leads to microcytic anemia.
Title: Abnormal erythroid maturation leads to microcytic anemia in the TSAP6/Steap3 null mouse model.
Steap3 deficiency causes abnormal iron status and homeostasis, which leads to impaired TLR4-mediated inflammatory responses in macrophages.
Title: Metalloreductase Steap3 coordinates the regulation of iron homeostasis and inflammatory responses.
Data show that the STEAP3/TSAP6 is absent in the mouse embryo fibroblasts derived from the STEAP3/TSAP6 knock-out mice (MEFs KO), but present in the wild type MEFs.
Title: A novel type of congenital hypochromic anemia associated with a nonsense mutation in the STEAP3/TSAP6 gene.
hypochromic microcytic anemia results from a Y228H substitution in the ferrireductase Steap3 (Steap3(Y288H))
Title: Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism.
The DNA damage-induced p53-dependent nonclassical exosomal secretory pathway is abrogated in TSAP6-null cells.
Title: Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice.
TSAP6 may augment Myt1 activity and act downstream to p53 to interface apoptosis and cell-cycle progression
Title: The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (5) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables FAD binding	ISO Inferred from Sequence Orthology more info
enables cupric reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cupric reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables ferric-chelate reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables ferric-chelate reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables ferric-chelate reductase (NADPH) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ferric-chelate reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables ferric-chelate reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables ferric-chelate reductase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables heme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in copper ion import	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within copper ion import	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within copper ion import	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exosomal secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within iron import into cell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within iron ion import across cell outer membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within iron ion import across cell outer membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within iron ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein secretion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein secretion	ISO Inferred from Sequence Orthology more info
involved_in protein secretion	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in multivesicular body	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: metalloreductase STEAP3

Names: dudulin 2; protein nm1054; six-transmembrane epithelial antigen of prostate 3; tumor suppressor-activated pathway protein 6

NP_001078878.1

EC 1.16.1.-

NP_001366283.1

EC 1.16.1.-

NP_001366284.1

EC 1.16.1.-

NP_573449.2

EC 1.16.1.-

XP_006529908.1

EC 1.16.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085409.2 → NP_001078878.1 metalloreductase STEAP3 isoform b

See identical proteins and their annotated locations for NP_001078878.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 all encode the same isoform (b).

Source sequence(s)

AC084310, AC139867

Consensus CDS

CCDS48343.1

UniProtKB/Swiss-Prot

Q3TKE4, Q80ZF3, Q8C5F0, Q8CI59, Q924Z1

UniProtKB/TrEMBL

A0A0R4J1G9

Related

ENSMUSP00000108260.2, ENSMUST00000112641.8

Conserved Domains (2) summary

COG2085
Location:29 → 209

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:262 → 405

Ferric_reduct; Ferric reductase like transmembrane component
NM_001379354.1 → NP_001366283.1 metalloreductase STEAP3 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3), as well as variants 1 and 2, encodes isoform b.

Source sequence(s)

AC084310, AC139867

UniProtKB/Swiss-Prot

Q3TKE4, Q80ZF3, Q8C5F0, Q8CI59, Q924Z1

UniProtKB/TrEMBL

A0A0R4J1G9

Related

ENSMUSP00000108258.2, ENSMUST00000112639.8

Conserved Domains (2) summary

COG2085
Location:29 → 209

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:262 → 405

Ferric_reduct; Ferric reductase like transmembrane component
NM_001379355.1 → NP_001366284.1 metalloreductase STEAP3 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (4) encodes the longer isoform (a).

Source sequence(s)

AC084310, AC139867

UniProtKB/Swiss-Prot

Q3TKE4, Q80ZF3, Q8C5F0, Q8CI59, Q924Z1

Conserved Domains (2) summary

COG2085
Location:39 → 219

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:272 → 415

Ferric_reduct; Ferric reductase like transmembrane component
NM_133186.4 → NP_573449.2 metalloreductase STEAP3 isoform b

See identical proteins and their annotated locations for NP_573449.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (b).

Source sequence(s)

AC084310, AC139867

Consensus CDS

CCDS48343.1

UniProtKB/Swiss-Prot

Q3TKE4, Q80ZF3, Q8C5F0, Q8CI59, Q924Z1

UniProtKB/TrEMBL

A0A0R4J1G9

Related

ENSMUSP00000108259.2, ENSMUST00000112640.8

Conserved Domains (2) summary

COG2085
Location:29 → 209

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:262 → 405

Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

120154137..120198810 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529845.4 → XP_006529908.1 metalloreductase STEAP3 isoform X1

UniProtKB/Swiss-Prot

Q3TKE4, Q80ZF3, Q8C5F0, Q8CI59, Q924Z1

UniProtKB/TrEMBL

E9QN92

Related

ENSMUSP00000108262.2, ENSMUST00000112643.2

Conserved Domains (2) summary

COG2085
Location:67 → 247

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:300 → 443

Ferric_reduct; Ferric reductase like transmembrane component