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    Ica1l islet cell autoantigen 1-like [ Mus musculus (house mouse) ]

    Gene ID: 70375, updated on 9-May-2024

    Summary

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    Official Symbol
    Ica1lprovided by MGI
    Official Full Name
    islet cell autoantigen 1-likeprovided by MGI
    Primary source
    MGI:MGI:1917625
    See related
    Ensembl:ENSMUSG00000026018 AllianceGenome:MGI:1917625
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Als2cr15; b2b3465Clo; 1700030B17Rik
    Summary
    Predicted to enable protein domain specific binding activity. Acts upstream of or within spermatid development. Located in acrosomal vesicle. Orthologous to human ICA1L (islet cell autoantigen 1 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 8.3), CNS E18 (RPKM 6.5) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C2; 1 30.45 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (60024955..60082646, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (59985796..60043481, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene bone morphogenetic protein receptor type 2 Neighboring gene STARR-seq mESC enhancer starr_01055 Neighboring gene STARR-positive B cell enhancer ABC_E5760 Neighboring gene family with sequence similarity 117, member B Neighboring gene arginyl-tRNA synthetase 2, mitochondrial pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr1:60073097-60073398 Neighboring gene STARR-seq mESC enhancer starr_01058 Neighboring gene STARR-seq mESC enhancer starr_01059 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:60154934-60155145 Neighboring gene WD repeat domain 12 Neighboring gene calcium response factor Neighboring gene predicted gene 15464

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis. He J, et al. J Cell Sci, 2015 Oct 15. PMID 26306493
    2. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, et al. Nature, 2015 May 28. PMID 25807483, Free PMC Article
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.
      Title: ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (4)  1 citation
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    islet cell autoantigen 1-like protein
    Names
    Ica69-related protein
    amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 15
    amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316694.2 → NP_001303623.1  islet cell autoantigen 1-like protein isoform a

      Status: VALIDATED

      Source sequence(s)
      AC125377
      Consensus CDS
      CCDS14987.1
      UniProtKB/Swiss-Prot
      Q3TY65, Q6AXB8, Q6PD23, Q8C0R6, Q9D9S5
      UniProtKB/TrEMBL
      A0A087WSM1
      Related
      ENSMUSP00000140520.2, ENSMUST00000191251.7
      Conserved Domains (2) summary
      pfam04629
      Location:254 → 431
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      pfam06456
      Location:15 → 242
      Arfaptin; Arfaptin-like domain

    2. NM_001316695.2 → NP_001303624.1  islet cell autoantigen 1-like protein isoform b

      Status: VALIDATED

      Source sequence(s)
      AC125377
      Related
      ENSMUST00000186970.2
      Conserved Domains (1) summary
      cl12013
      Location:15 → 84
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. NM_001357296.2 → NP_001344225.1  islet cell autoantigen 1-like protein isoform a

      Status: VALIDATED

      Source sequence(s)
      AC125377
      Consensus CDS
      CCDS14987.1
      UniProtKB/Swiss-Prot
      Q3TY65, Q6AXB8, Q6PD23, Q8C0R6, Q9D9S5
      UniProtKB/TrEMBL
      A0A087WSM1
      Conserved Domains (2) summary
      pfam04629
      Location:254 → 431
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      pfam06456
      Location:15 → 242
      Arfaptin; Arfaptin-like domain

    4. NM_027407.5 → NP_081683.3  islet cell autoantigen 1-like protein isoform a

      See identical proteins and their annotated locations for NP_081683.3

      Status: VALIDATED

      Source sequence(s)
      AC125377
      Consensus CDS
      CCDS14987.1
      UniProtKB/Swiss-Prot
      Q3TY65, Q6AXB8, Q6PD23, Q8C0R6, Q9D9S5
      UniProtKB/TrEMBL
      A0A087WSM1
      Related
      ENSMUSP00000027172.7, ENSMUST00000027172.13
      Conserved Domains (2) summary
      pfam04629
      Location:254 → 431
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      pfam06456
      Location:15 → 242
      Arfaptin; Arfaptin-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      60024955..60082646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153607.1 → XP_036009500.1  islet cell autoantigen 1-like protein isoform X7

      Conserved Domains (2) summary
      pfam04629
      Location:327 → 365
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:67 → 269
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_036153596.1 → XP_036009489.1  islet cell autoantigen 1-like protein isoform X1

      UniProtKB/TrEMBL
      A0A087WSM1
      Conserved Domains (2) summary
      pfam04629
      Location:276 → 452
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:67 → 269
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. XM_030242893.2 → XP_030098753.1  islet cell autoantigen 1-like protein isoform X2

      UniProtKB/TrEMBL
      A0A087WSM1
      Conserved Domains (2) summary
      pfam04629
      Location:248 → 425
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      pfam06456
      Location:15 → 236
      Arfaptin; Arfaptin-like domain

    4. XM_036153605.1 → XP_036009498.1  islet cell autoantigen 1-like protein isoform X5

      UniProtKB/TrEMBL
      A0A087WSM1
      Conserved Domains (2) summary
      pfam04629
      Location:255 → 414
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:46 → 248
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    5. XM_017312240.3 → XP_017167729.1  islet cell autoantigen 1-like protein isoform X5

      UniProtKB/TrEMBL
      A0A087WSM1
      Conserved Domains (2) summary
      pfam04629
      Location:255 → 414
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:46 → 248
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    6. XM_011238597.4 → XP_011236899.1  islet cell autoantigen 1-like protein isoform X4

      See identical proteins and their annotated locations for XP_011236899.1

      UniProtKB/Swiss-Prot
      Q3TY65, Q6AXB8, Q6PD23, Q8C0R6, Q9D9S5
      UniProtKB/TrEMBL
      A0A087WSM1
      Conserved Domains (2) summary
      pfam04629
      Location:254 → 431
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      pfam06456
      Location:15 → 242
      Arfaptin; Arfaptin-like domain

    7. XM_006496270.3 → XP_006496333.1  islet cell autoantigen 1-like protein isoform X4

      See identical proteins and their annotated locations for XP_006496333.1

      UniProtKB/Swiss-Prot
      Q3TY65, Q6AXB8, Q6PD23, Q8C0R6, Q9D9S5
      UniProtKB/TrEMBL
      A0A087WSM1
      Conserved Domains (2) summary
      pfam04629
      Location:254 → 431
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      pfam06456
      Location:15 → 242
      Arfaptin; Arfaptin-like domain

    8. XM_017312238.2 → XP_017167727.1  islet cell autoantigen 1-like protein isoform X2

      UniProtKB/TrEMBL
      A0A087WSM1
      Conserved Domains (2) summary
      pfam04629
      Location:248 → 425
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      pfam06456
      Location:15 → 236
      Arfaptin; Arfaptin-like domain

    9. XM_006496272.3 → XP_006496335.1  islet cell autoantigen 1-like protein isoform X9

      See identical proteins and their annotated locations for XP_006496335.1

      Conserved Domains (2) summary
      pfam04629
      Location:150 → 327
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:1 → 144
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    10. XM_036153597.1 → XP_036009490.1  islet cell autoantigen 1-like protein isoform X3

      UniProtKB/TrEMBL
      A0A087WSM1
      Conserved Domains (2) summary
      pfam04629
      Location:276 → 435
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:67 → 269
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    11. XM_030242896.2 → XP_030098756.1  islet cell autoantigen 1-like protein isoform X8

      Conserved Domains (2) summary
      pfam04629
      Location:310 → 344
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:46 → 248
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    12. XM_030242895.1 → XP_030098755.1  islet cell autoantigen 1-like protein isoform X6

      UniProtKB/TrEMBL
      A0A087WSM1
      Conserved Domains (2) summary
      pfam04629
      Location:248 → 408
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      pfam06456
      Location:15 → 236
      Arfaptin; Arfaptin-like domain

    13. XM_030242894.2 → XP_030098754.1  islet cell autoantigen 1-like protein isoform X5

      UniProtKB/TrEMBL
      A0A087WSM1
      Related
      ENSMUSP00000141103.2, ENSMUST00000189776.2
      Conserved Domains (2) summary
      pfam04629
      Location:255 → 414
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:46 → 248
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    14. XM_030242898.2 → XP_030098758.1  islet cell autoantigen 1-like protein isoform X10

      Conserved Domains (1) summary
      cl12013
      Location:15 → 84
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    15. XM_017312257.3 → XP_017167746.1  islet cell autoantigen 1-like protein isoform X10

      Conserved Domains (1) summary
      cl12013
      Location:15 → 84
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    16. XM_030242897.2 → XP_030098757.1  islet cell autoantigen 1-like protein isoform X10

      Conserved Domains (1) summary
      cl12013
      Location:15 → 84
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    17. XM_030242900.1 → XP_030098760.1  islet cell autoantigen 1-like protein isoform X10

      Conserved Domains (1) summary
      cl12013
      Location:15 → 84
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    18. XM_017312256.2 → XP_017167745.1  islet cell autoantigen 1-like protein isoform X10

      Conserved Domains (1) summary
      cl12013
      Location:15 → 84
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TY65.1 GenPept UniProtKB/Swiss-Prot:Q3TY65

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