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    Lancl1 LanC (bacterial lantibiotic synthetase component C)-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 14768, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Lancl1provided by MGI
    Official Full Name
    LanC (bacterial lantibiotic synthetase component C)-like 1provided by MGI
    Primary source
    MGI:MGI:1336997
    See related
    Ensembl:ENSMUSG00000026000 AllianceGenome:MGI:1336997
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p40; Gpr69; Gpr69a
    Summary
    Enables glutathione transferase activity. Involved in regulation of neuron apoptotic process and regulation of oxidative stress-induced neuron death. Predicted to be located in cytoplasm and membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human LANCL1 (LanC like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 84.4), cortex adult (RPKM 23.2) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C3; 1 33.75 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (67039676..67078049, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (67000517..67038891, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31, pseudogene 14 Neighboring gene STARR-seq mESC enhancer starr_01194 Neighboring gene histidyl-tRNA synthetase pseudogene Neighboring gene predicted gene, 57531 Neighboring gene STARR-seq mESC enhancer starr_01196 Neighboring gene carbamoyl-phosphate synthetase 1 Neighboring gene STARR-seq mESC enhancer starr_01197 Neighboring gene predicted gene, 26342

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice. Tan H, et al. Cell Death Differ, 2020 Apr. PMID 31570855, Free PMC Article
    2. Molecular characterization and tissue-specific expression of a murine putative G-protein-coupled receptor. Mayer H, et al. Biochim Biophys Acta, 1998 Jul 30. PMID 9714732
    3. Animal models of male subfertility targeted on LanCL1-regulated spermatogenic redox homeostasis. Huang C, et al. Lab Anim (NY), 2022 May. PMID 35469022
    4. Germ cell differentiation-dependent and stage-specific expression of LANCL1 in rodent testis. Nielsen JE, et al. Eur J Histochem, 2003. PMID 14514412
    5. Organization and chromosomal localization of the human and mouse genes coding for LanC-like protein 1 (LANCL1). Mayer H, et al. Cytogenet Cell Genet, 2001. PMID 11474189

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice.
      Title: LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice.
    2. Very similar concentrations of lanthionine ketimine (0.5-2.5 nmol/g tissue) were found in LanCL1 knock-out, LanCL1/LanCL2/LanCL3 triple-knock-out and wild type (WT) mouse brains, suggesting that LanCL proteins are not involved in lanthionine biosynthesis.
      Title: LanCL proteins are not Involved in Lanthionine Synthesis in Mammals.
    3. Loss of LanCL1 causes progressive oxidative damage and neuronal death. LanCL1 transgene protects neurons from oxidative stress.
      Title: Developmental and activity-dependent expression of LanCL1 confers antioxidant activity required for neuronal survival.
    4. Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine beta-synthase: a target for neuronal antioxidant defense.
      Title: Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine β-synthase: a target for neuronal antioxidant defense.
    5. LanC-like protein 1 expression in rat testes was initiated already in pachytene spermatocytes in stage IX, but otherwise similar to mouse.
      Title: Germ cell differentiation-dependent and stage-specific expression of LANCL1 in rodent testis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular detoxification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptide modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase LANCL1
    Names
    40 kDa erythrocyte membrane protein
    G protein-coupled receptor 69
    G protein-coupled receptor 69A
    LanC-like protein 1
    NP_001177913.1
    NP_001177914.1
    NP_067270.1
    XP_011236737.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190984.1 → NP_001177913.1  glutathione S-transferase LANCL1

      See identical proteins and their annotated locations for NP_001177913.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC133187, BC058560
      Consensus CDS
      CCDS15025.1
      UniProtKB/Swiss-Prot
      O89112
      Related
      ENSMUSP00000113080.2, ENSMUST00000119559.8
      Conserved Domains (2) summary
      cd04794
      Location:62 → 395
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
      cl04955
      Location:1 → 89
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

    2. NM_001190985.1 → NP_001177914.1  glutathione S-transferase LANCL1

      See identical proteins and their annotated locations for NP_001177914.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC133187
      Consensus CDS
      CCDS15025.1
      UniProtKB/Swiss-Prot
      O89112
      Related
      ENSMUSP00000109612.4, ENSMUST00000113979.10
      Conserved Domains (2) summary
      cd04794
      Location:62 → 395
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
      cl04955
      Location:1 → 89
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

    3. NM_021295.3 → NP_067270.1  glutathione S-transferase LANCL1

      See identical proteins and their annotated locations for NP_067270.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC133187, Y11550
      Consensus CDS
      CCDS15025.1
      UniProtKB/Swiss-Prot
      O89112
      Related
      ENSMUSP00000027149.6, ENSMUST00000027149.12
      Conserved Domains (2) summary
      cd04794
      Location:62 → 395
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
      cl04955
      Location:1 → 89
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      67039676..67078049 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238435.4 → XP_011236737.1  glutathione S-transferase LANCL1 isoform X1

      Conserved Domains (1) summary
      cd04794
      Location:16 → 349
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O89112.1 GenPept UniProtKB/Swiss-Prot:O89112

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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