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    Ikzf2 IKAROS family zinc finger 2 [ Mus musculus (house mouse) ]

    Gene ID: 22779, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Ikzf2provided by MGI
    Official Full Name
    IKAROS family zinc finger 2provided by MGI
    Primary source
    MGI:MGI:1342541
    See related
    Ensembl:ENSMUSG00000025997 AllianceGenome:MGI:1342541
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Helios; Zfpn1a2; Znfn1a2; A730095J18Rik
    Summary
    Enables identical protein binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in early conceptus and genitourinary system. Orthologous to human IKZF2 (IKAROS family zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 4.1), thymus adult (RPKM 2.6) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ikzf2 in Genome Data Viewer
    Location:
    1 C3; 1 34.9 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (69570382..69726510, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (69531207..69687351, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene PC-esterase domain containing 1C, pseudogene Neighboring gene STARR-seq mESC enhancer starr_01215 Neighboring gene predicted gene 28497 Neighboring gene STARR-seq mESC enhancer starr_01218 Neighboring gene STARR-seq mESC enhancer starr_01219 Neighboring gene STARR-seq mESC enhancer starr_01220 Neighboring gene predicted gene, 53559 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:69815414-69815635 Neighboring gene predicted gene, 29822 Neighboring gene STARR-seq mESC enhancer starr_01224 Neighboring gene sperm associated antigen 16 Neighboring gene predicted gene, 23879

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ikzf2 Regulates the Development of ICOS(+) Th Cells to Mediate Immune Response in the Spleen of S. japonicum-Infected C57BL/6 Mice. Xie S, et al. Front Immunol, 2021. PMID 34475870, Free PMC Article
    2. Lack of Helios During Neural Development Induces Adult Schizophrenia-Like Behaviors Associated With Aberrant Levels of the TRIF-Recruiter Protein WDFY1. Sancho-Balsells A, et al. Front Cell Neurosci, 2020. PMID 32477064, Free PMC Article
    3. Helios(+) and Helios(-) Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires. Thornton AM, et al. Eur J Immunol, 2019 Mar. PMID 30620397, Free PMC Article
    4. IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation. Park SM, et al. Cell Stem Cell, 2019 Jan 3. PMID 30472158, Free PMC Article
    5. Generation of Helios reporter mice and an evaluation of the suppressive capacity of Helios(+) regulatory T cells in vitro. Sugita K, et al. Exp Dermatol, 2015 Jul. PMID 25846704

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD4[+] regulatory T cells lacking Helios and Eos.
      Title: CD4(+) regulatory T cells lacking Helios and Eos.
    2. Epistatic genetic interactions between Insm1 and Ikzf2 during cochlear outer hair cell development.
      Title: Epistatic genetic interactions between Insm1 and Ikzf2 during cochlear outer hair cell development.
    3. Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.
      Title: Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.
    4. Ikzf2 Regulates the Development of ICOS(+) Th Cells to Mediate Immune Response in the Spleen of S. japonicum-Infected C57BL/6 Mice.
      Title: Ikzf2 Regulates the Development of ICOS(+) Th Cells to Mediate Immune Response in the Spleen of S. japonicum-Infected C57BL/6 Mice.
    5. RNA-Binding Protein ZFP36L2 Downregulates Helios Expression and Suppresses the Function of Regulatory T Cells.
      Title: RNA-Binding Protein ZFP36L2 Downregulates Helios Expression and Suppresses the Function of Regulatory T Cells.
    6. Our results demonstrated that...Helios has a specific and important role for a correct function of hippocampal calbindin-positive CA1 pyramidal neurons regulating spinogenesis...and that Visinin-like protein 1 (VSNL1) could play an important role in such processes
      Title: Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation.
    7. CD4+ Tconv cells can differentiate into both RORgamma+ and Helios+ pTreg cells.
      Title: Developmental and cellular age direct conversion of CD4+ T cells into RORγ+ or Helios+ colon Treg cells.
    8. Data show that zinc finger protein subfamily 1A 2 (Helios)Helios(+) and Helios(-) Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires.
      Title: Helios(+) and Helios(-) Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires.
    9. The transcription factor Helios, a member of the Ikaros transcription factor family, is expressed in 60-70% of Treg cells in both mouse and man, and is believed to be a marker of tTreg cells.
      Title: Helios: still behind the clouds.
    10. identification of Ikzf2 (which encodes Helios) as an essential transcription factor in mice that is required for outer hair cells functional maturation and hearing
      Title: Helios is a key transcriptional regulator of outer hair cell maturation.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein Helios
    Names
    ikaros family zinc finger protein 2
    zinc finger protein, subfamily 1A, 2 (Helios)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402850.1 → NP_001389779.1  zinc finger protein Helios isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC101737

    2. NM_001402852.1 → NP_001389781.1  zinc finger protein Helios isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC101737
      UniProtKB/Swiss-Prot
      P81183, Q8C8A3

    3. NM_001402853.1 → NP_001389782.1  zinc finger protein Helios isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC101737
      UniProtKB/Swiss-Prot
      P81183, Q8C8A3

    4. NM_001402854.1 → NP_001389783.1  zinc finger protein Helios isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC101737
      UniProtKB/Swiss-Prot
      P81183, Q8C8A3

    5. NM_001402855.1 → NP_001389784.1  zinc finger protein Helios isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC101737

    6. NM_001402856.1 → NP_001389785.1  zinc finger protein Helios isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC101737
      Related
      ENSMUSP00000141075.2, ENSMUST00000187184.7

    7. NM_001402857.1 → NP_001389786.1  zinc finger protein Helios isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC101737
      UniProtKB/Swiss-Prot
      P81183, Q8C8A3

    8. NM_011770.5 → NP_035900.2  zinc finger protein Helios isoform 2

      See identical proteins and their annotated locations for NP_035900.2

      Status: VALIDATED

      Source sequence(s)
      AC101737
      Consensus CDS
      CCDS15026.1
      UniProtKB/Swiss-Prot
      P81183, Q8C8A3
      UniProtKB/TrEMBL
      A0A087WQ51
      Related
      ENSMUSP00000027146.3, ENSMUST00000027146.9
      Conserved Domains (2) summary
      sd00017
      Location:114 → 134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:154 → 179
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      69570382..69726510 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164623.1 → XP_036020516.1  zinc finger protein Helios isoform X5

      UniProtKB/TrEMBL
      A0A087WQ51
      Conserved Domains (2) summary
      sd00017
      Location:115 → 135
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:155 → 180
      zf-H2C2_2; Zinc-finger double domain

    2. XM_030253862.2 → XP_030109722.1  zinc finger protein Helios isoform X2

      UniProtKB/TrEMBL
      A0A087WQ51
      Conserved Domains (2) summary
      sd00017
      Location:137 → 157
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:177 → 202
      zf-H2C2_2; Zinc-finger double domain

    3. XM_030253863.2 → XP_030109723.1  zinc finger protein Helios isoform X2

      UniProtKB/TrEMBL
      A0A087WQ51
      Conserved Domains (2) summary
      sd00017
      Location:137 → 157
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:177 → 202
      zf-H2C2_2; Zinc-finger double domain

    4. XM_030253867.2 → XP_030109727.1  zinc finger protein Helios isoform X3

      UniProtKB/TrEMBL
      A0A087WQ51
      Conserved Domains (2) summary
      sd00017
      Location:121 → 141
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:161 → 186
      zf-H2C2_2; Zinc-finger double domain

    5. XM_006495961.4 → XP_006496024.1  zinc finger protein Helios isoform X4

      UniProtKB/TrEMBL
      A0A087WNY4, A0A087WQ51
      Related
      ENSMUSP00000139543.2, ENSMUST00000190771.7
      Conserved Domains (2) summary
      sd00017
      Location:120 → 140
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:160 → 185
      zf-H2C2_2; Zinc-finger double domain

    6. XM_006495968.4 → XP_006496031.1  zinc finger protein Helios isoform X8

      UniProtKB/TrEMBL
      A0A087WQ74
      Conserved Domains (3) summary
      COG5048
      Location:130 → 204
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:151 → 176
      zf-H2C2_2; Zinc-finger double domain

    7. XM_011238508.3 → XP_011236810.1  zinc finger protein Helios isoform X5

      See identical proteins and their annotated locations for XP_011236810.1

      UniProtKB/TrEMBL
      A0A087WQ51
      Conserved Domains (2) summary
      sd00017
      Location:115 → 135
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:155 → 180
      zf-H2C2_2; Zinc-finger double domain

    8. XM_011238509.3 → XP_011236811.1  zinc finger protein Helios isoform X7

      UniProtKB/TrEMBL
      A0A087WQ74
      Conserved Domains (3) summary
      COG5048
      Location:131 → 205
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:140 → 160
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152 → 177
      zf-H2C2_2; Zinc-finger double domain

    9. XM_011238504.3 → XP_011236806.1  zinc finger protein Helios isoform X1

      UniProtKB/TrEMBL
      A0A087WQ51
      Conserved Domains (2) summary
      sd00017
      Location:138 → 158
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:178 → 203
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P81183.2 GenPept UniProtKB/Swiss-Prot:P81183

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