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    Shisa5 shisa family member 5 [ Mus musculus (house mouse) ]

    Gene ID: 66940, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Shisa5provided by MGI
    Official Full Name
    shisa family member 5provided by MGI
    Primary source
    MGI:MGI:1915044
    See related
    Ensembl:ENSMUSG00000025647 AllianceGenome:MGI:1915044
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Scotin; mShisa5; 2310008D10Rik; 6430628I05Rik
    Summary
    Predicted to enable WW domain binding activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Located in endoplasmic reticulum and nuclear envelope. Is expressed in chorion; extraembryonic ectoderm; foregut diverticulum; and yolk sac. Orthologous to human SHISA5 (shisa family member 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 466.2), mammary gland adult (RPKM 229.2) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 F2; 9 59.63 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108867635..108886860)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (109038567..109057792)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E192 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Neighboring gene urocortin 2 Neighboring gene STARR-seq mESC enhancer starr_25229 Neighboring gene STARR-positive B cell enhancer ABC_E5105 Neighboring gene STARR-positive B cell enhancer ABC_E5106 Neighboring gene STARR-positive B cell enhancer ABC_E10586 Neighboring gene STARR-positive B cell enhancer ABC_E10587 Neighboring gene STARR-positive B cell enhancer ABC_E5107 Neighboring gene predicted gene, 53191 Neighboring gene three prime repair exonuclease 1 Neighboring gene ATR interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Scotin: A new p63 target gene expressed during epidermal differentiation. Zocchi L, et al. Biochem Biophys Res Commun, 2008 Mar 7. PMID 18164684, Free PMC Article
    2. The calcium binding protein ALG-2 binds and stabilizes Scotin, a p53-inducible gene product localized at the endoplasmic reticulum membrane. Draeby I, et al. Arch Biochem Biophys, 2007 Nov 1. PMID 17889823, Free PMC Article
    3. Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane. Bourdon JC, et al. J Cell Biol, 2002 Jul 22. PMID 12135983, Free PMC Article
    4. Cell cycle regulation by the pro-apoptotic gene Scotin. Gupta RK, et al. Cell Cycle, 2008 Aug. PMID 18677103
    5. Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. Furushima K, et al. Dev Biol, 2007 Jun 15. PMID 17481602

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mouse Scotin induces apoptosis and developmental defects when overexpressed in Drosophila.
      Title: Cell cycle regulation by the pro-apoptotic gene Scotin.
    2. We conclude that Scotin is a new p63 target gene induced during epithelial differentiation, a complex process that also involves ER stress induction.
      Title: Scotin: A new p63 target gene expressed during epidermal differentiation.
    3. ALG-2 binding to Scotin is strictly calcium dependent, indicating a role of this interaction in calcium signaling pathways
      Title: The calcium binding protein ALG-2 binds and stabilizes Scotin, a p53-inducible gene product localized at the endoplasmic reticulum membrane.
    4. Scotin plays a role in p53-dependent apoptosis
      Title: Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein shisa-5
    Names
    shisa homolog 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284332.1 → NP_001271261.1  protein shisa-5 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001271261.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest protein (isoform 3).
      Source sequence(s)
      AC140383, AK212074
      Consensus CDS
      CCDS72309.1
      UniProtKB/Swiss-Prot
      Q9D7I0
      Related
      ENSMUSP00000107690.6, ENSMUST00000112059.10
      Conserved Domains (1) summary
      pfam13908
      Location:26 → 192
      Shisa; Wnt and FGF inhibitory regulator

    2. NM_001357932.1 → NP_001344861.1  protein shisa-5 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC140383
      Consensus CDS
      CCDS90665.1
      UniProtKB/TrEMBL
      A0A0G2JGP8, Q8BU09
      Related
      ENSMUSP00000143648.2, ENSMUST00000197099.5
      Conserved Domains (1) summary
      pfam13908
      Location:11 → 123
      Shisa; Wnt and FGF inhibitory regulator

    3. NM_001357933.1 → NP_001344862.1  protein shisa-5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC140383, AK090357
      Consensus CDS
      CCDS90666.1
      UniProtKB/TrEMBL
      Q8BU09
      Related
      ENSMUSP00000142835.2, ENSMUST00000200515.5
      Conserved Domains (1) summary
      pfam13908
      Location:15 → 127
      Shisa; Wnt and FGF inhibitory regulator

    4. NM_001357934.1 → NP_001344863.1  protein shisa-5 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC140383
      UniProtKB/TrEMBL
      A0A0G2JER0
      Conserved Domains (1) summary
      pfam13908
      Location:17 → 103
      Shisa; Wnt and FGF inhibitory regulator

    5. NM_001357935.1 → NP_001344864.1  protein shisa-5 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 8-12, encodes isoform 7.
      Source sequence(s)
      AC140383
      Consensus CDS
      CCDS90667.1
      UniProtKB/TrEMBL
      A0A0G2JER0, A0A0G2JGK4
      Related
      ENSMUSP00000142978.2, ENSMUST00000198708.5
      Conserved Domains (1) summary
      pfam13908
      Location:1 → 89
      Shisa; Wnt and FGF inhibitory regulator

    6. NM_001357936.1 → NP_001344865.1  protein shisa-5 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 7 and 9-12, encodes isoform 7.
      Source sequence(s)
      AC140383
      Consensus CDS
      CCDS90667.1
      UniProtKB/TrEMBL
      A0A0G2JER0, A0A0G2JGK4
      Conserved Domains (1) summary
      pfam13908
      Location:1 → 89
      Shisa; Wnt and FGF inhibitory regulator

    7. NM_001357937.1 → NP_001344866.1  protein shisa-5 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 7, 8, and 10-12, encodes isoform 7.
      Source sequence(s)
      AC140383
      Consensus CDS
      CCDS90667.1
      UniProtKB/TrEMBL
      A0A0G2JER0, A0A0G2JGK4
      Conserved Domains (1) summary
      pfam13908
      Location:1 → 89
      Shisa; Wnt and FGF inhibitory regulator

    8. NM_001357939.1 → NP_001344868.1  protein shisa-5 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 7-9, 11, and 12, encodes isoform 7.
      Source sequence(s)
      AC140383
      Consensus CDS
      CCDS90667.1
      UniProtKB/TrEMBL
      A0A0G2JER0, A0A0G2JGK4
      Related
      ENSMUSP00000143613.2, ENSMUST00000197483.5
      Conserved Domains (1) summary
      pfam13908
      Location:1 → 89
      Shisa; Wnt and FGF inhibitory regulator

    9. NM_001357940.1 → NP_001344869.1  protein shisa-5 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 7-10 and 12, encodes isoform 7.
      Source sequence(s)
      AC140383, BF731565
      Consensus CDS
      CCDS90667.1
      UniProtKB/TrEMBL
      A0A0G2JER0, A0A0G2JGK4
      Conserved Domains (1) summary
      pfam13908
      Location:1 → 89
      Shisa; Wnt and FGF inhibitory regulator

    10. NM_001357941.1 → NP_001344870.1  protein shisa-5 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 7-11, encodes isoform 7.
      Source sequence(s)
      AA088083, AC140383
      Consensus CDS
      CCDS90667.1
      UniProtKB/TrEMBL
      A0A0G2JER0, A0A0G2JGK4
      Related
      ENSMUSP00000143599.2, ENSMUST00000196954.5
      Conserved Domains (1) summary
      pfam13908
      Location:1 → 89
      Shisa; Wnt and FGF inhibitory regulator

    11. NM_025858.3 → NP_080134.1  protein shisa-5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_080134.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate splice site in the coding region compared to variant 3. The resulting protein (isoform 1) is shorter but has the same N- and C-termini compared to isoform 3.
      Source sequence(s)
      AC140383, AK033545
      Consensus CDS
      CCDS23543.1
      UniProtKB/Swiss-Prot
      Q8BJ86, Q8BJ87, Q8BLE9, Q8K4W3, Q91Z37, Q9CQP5, Q9D7I0
      Related
      ENSMUSP00000026737.8, ENSMUST00000026737.12
      Conserved Domains (1) summary
      pfam13908
      Location:26 → 191
      Shisa; Wnt and FGF inhibitory regulator

    12. NM_026381.5 → NP_080657.1  protein shisa-5 isoform 2

      See identical proteins and their annotated locations for NP_080657.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' terminal exon and initiates translation at an alternate start codon compared to variant 3. The resulting protein (isoform 2) has a distinct N-terminus and is shorter than isoform 3.
      Source sequence(s)
      AC140383, AK081060
      Consensus CDS
      CCDS40771.1
      UniProtKB/TrEMBL
      A0A0G2JER0
      Related
      ENSMUSP00000128901.2, ENSMUST00000154184.5
      Conserved Domains (1) summary
      pfam13908
      Location:2 → 88
      Shisa; Wnt and FGF inhibitory regulator

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108867635..108886860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244508.2 → XP_030100368.1  protein shisa-5 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JER0, A0A0G2JGK4
      Conserved Domains (1) summary
      pfam13908
      Location:1 → 89
      Shisa; Wnt and FGF inhibitory regulator

    2. XM_030244506.1 → XP_030100366.1  protein shisa-5 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JER0, A0A0G2JGK4
      Conserved Domains (1) summary
      pfam13908
      Location:1 → 89
      Shisa; Wnt and FGF inhibitory regulator

    3. XM_006512212.4 → XP_006512275.1  protein shisa-5 isoform X1

      See identical proteins and their annotated locations for XP_006512275.1

      Conserved Domains (1) summary
      pfam13908
      Location:39 → 127
      Shisa; Wnt and FGF inhibitory regulator
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7I0.1 GenPept UniProtKB/Swiss-Prot:Q9D7I0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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