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    Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 13106, updated on 11-Apr-2024

    Summary

    Official Symbol
    Cyp2e1provided by MGI
    Official Full Name
    cytochrome P450, family 2, subfamily e, polypeptide 1provided by MGI
    Primary source
    MGI:MGI:88607
    See related
    Ensembl:ENSMUSG00000025479 AllianceGenome:MGI:88607
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cyp2e; CYPIIE1
    Summary
    Enables monooxygenase activity. Acts upstream of or within response to bacterium. Located in endoplasmic reticulum. Is expressed in several structures, including cardiovascular system; exocrine gland; foregut; liver and biliary system; and white fat. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; fatty liver disease; gastrointestinal system cancer (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human CYP2E1 (cytochrome P450 family 2 subfamily E member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 981.7), subcutaneous fat pad adult (RPKM 122.6) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Cyp2e1 in Genome Data Viewer
    Location:
    7 F4; 7 85.94 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140343732..140354903)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140763819..140774990)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 13 subfamily A member 26 Neighboring gene olfactory receptor family 13 subfamily S member 1, pseudogene 1 Neighboring gene synaptonemal complex central element protein 1 Neighboring gene predicted gene, 29799 Neighboring gene zinc finger protein 941

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4-nitrophenol 2-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables arachidonic acid epoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aromatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables long-chain fatty acid omega-1 hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in 4-nitrophenol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epoxygenase P450 pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heterocycle metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid hydroxylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoterpenoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cytochrome P450 2E1
    Names
    4-nitrophenol 2-hydroxylase
    cytochrome P450, 2e1, ethanol inducible
    cytochrome P450-ALC
    cytochrome P450-J
    NP_067257.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021282.3NP_067257.1  cytochrome P450 2E1

      See identical proteins and their annotated locations for NP_067257.1

      Status: VALIDATED

      Source sequence(s)
      AC107815
      Consensus CDS
      CCDS21985.1
      UniProtKB/Swiss-Prot
      Q05421, Q9Z198
      UniProtKB/TrEMBL
      A0A1B0GSV7
      Related
      ENSMUSP00000026552.8, ENSMUST00000026552.9
      Conserved Domains (1) summary
      pfam00067
      Location:44489
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140343732..140354903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)