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    Atp10a ATPase, class V, type 10A [ Mus musculus (house mouse) ]

    Gene ID: 11982, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Atp10aprovided by MGI
    Official Full Name
    ATPase, class V, type 10Aprovided by MGI
    Primary source
    MGI:MGI:1330809
    See related
    Ensembl:ENSMUSG00000025324 AllianceGenome:MGI:1330809
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    pfatp; Atp10c
    Summary
    Predicted to enable glycosylceramide flippase activity and phosphatidylcholine flippase activity. Predicted to be involved in phospholipid translocation and positive regulation of membrane tubulation. Predicted to act upstream of or within lipid transport. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of plasma membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; brain; dorsal grey horn; lung; and testis. Orthologous to human ATP10A (ATPase phospholipid transporting 10A (putative)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thymus adult (RPKM 15.3), adrenal adult (RPKM 11.8) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B5; 7 33.88 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (58305896..58479783)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (58656142..58830244)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26288 Neighboring gene STARR-seq mESC enhancer starr_18982 Neighboring gene STARR-positive B cell enhancer ABC_E6550 Neighboring gene nuclear encoded tRNA glutamic acid 7 (anticodon TTC) Neighboring gene STARR-seq mESC enhancer starr_18985 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:65913391-65913574 Neighboring gene STARR-seq mESC enhancer starr_18986 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:65952583-65952778 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:65997400-65997583 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:66010520-66010731 Neighboring gene predicted gene, 39019 Neighboring gene non-catalytic region of tyrosine kinase adaptor protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18988 Neighboring gene STARR-seq mESC enhancer starr_18989 Neighboring gene crumbs homolog 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Atp10a, the mouse ortholog of the human imprinted ATP10A gene, escapes genomic imprinting. Kayashima T, et al. Genomics, 2003 Jun. PMID 12782135
    2. Predominant maternal expression of the mouse Atp10c in hippocampus and olfactory bulb. Kashiwagi A, et al. J Hum Genet, 2003. PMID 12730723
    3. Atp10a, a gene adjacent to the PWS/AS gene cluster, is not imprinted in mouse and is insensitive to the PWS-IC. DuBose AJ, et al. Neurogenetics, 2010 May. PMID 19894069
    4. Mice heterozygous for Atp10c, a putative amphipath, represent a novel model of obesity and type 2 diabetes. Dhar MS, et al. J Nutr, 2004 Apr. PMID 15051828
    5. An aminophospholipid translocase associated with body fat and type 2 diabetes phenotypes. Dhar M, et al. Obes Res, 2002 Jul. PMID 12105293

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice.
      Title: Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice.
    2. Data report that Atp10a is biallelically expressed in both the newborn and adult brain, and Atp10a allelic expression is insensitive to deletion or mutation of the PWS imprinting center.
      Title: Atp10a, a gene adjacent to the PWS/AS gene cluster, is not imprinted in mouse and is insensitive to the PWS-IC.
    3. report the generation of the complete genomic structure
      Title: An aminophospholipid translocase associated with body fat and type 2 diabetes phenotypes.
    4. Atp10a was biallelically expressed in all tissues examined. Furthermore, there was no differential methylation in the CpG island and no antisense transcripts of the gene. These findings suggest that the mouse Atp10a gene escapes genomic imprinting.
      Title: Atp10a, the mouse ortholog of the human imprinted ATP10A gene, escapes genomic imprinting.
    5. A putative phospholipid transporter, is the only coding unit between Gabrb3 and Ube3a.
      Title: Physical mapping of the pink-eyed dilution complex in mouse chromosome 7 shows that Atp10c is the only transcript between Gabrb3 and Ube3a.
    6. Atp10c/pfatp showed tissue-specific maternal expression in the hippocampus and olfactory bulb
      Title: Predominant maternal expression of the mouse Atp10c in hippocampus and olfactory bulb.
    7. data suggest that heterozygous deletion along with an unusual pattern of maternal inheritance of the chromosomal region containing the single gene, Atp10c, causes obesity, type 2 diabetes, and nonalcoholic fatty liver disease in these mice
      Title: Mice heterozygous for Atp10c, a putative amphipath, represent a novel model of obesity and type 2 diabetes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (4)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosylceramide flippase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine flippase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of phospholipid-translocating ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid-transporting ATPase VA
    Names
    ATPase 10A, class V
    ATPase, class 5
    P-locus fat-associated ATPase
    P4-ATPase flippase complex alpha subunit ATP10A
    probable phospholipid-transporting ATPase VA
    NP_033858.2
    XP_006540643.1
    XP_006540644.1
    XP_006540646.1
    XP_017177441.1
    XP_036008505.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009728.2 → NP_033858.2  phospholipid-transporting ATPase VA

      See identical proteins and their annotated locations for NP_033858.2

      Status: VALIDATED

      Source sequence(s)
      AC163271, AK132174, AK172972, AV273066
      Consensus CDS
      CCDS39972.1
      UniProtKB/Swiss-Prot
      O54827, Q8R3B8
      UniProtKB/TrEMBL
      Q3TA23, Q3V1Y7
      Related
      ENSMUSP00000129811.2, ENSMUST00000168747.3
      Conserved Domains (1) summary
      cd02073
      Location:65 → 1203
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      58305896..58479783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540581.4 → XP_006540644.1  phospholipid-transporting ATPase VA isoform X1

      See identical proteins and their annotated locations for XP_006540644.1

      UniProtKB/Swiss-Prot
      O54827, Q8R3B8
      UniProtKB/TrEMBL
      Q3TA23, Q3V1Y7
      Conserved Domains (1) summary
      cd02073
      Location:65 → 1203
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    2. XM_006540580.4 → XP_006540643.1  phospholipid-transporting ATPase VA isoform X1

      See identical proteins and their annotated locations for XP_006540643.1

      UniProtKB/Swiss-Prot
      O54827, Q8R3B8
      UniProtKB/TrEMBL
      Q3TA23, Q3V1Y7
      Conserved Domains (1) summary
      cd02073
      Location:65 → 1203
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    3. XM_036152612.1 → XP_036008505.1  phospholipid-transporting ATPase VA isoform X2

      Conserved Domains (1) summary
      cl21460
      Location:2 → 876
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    4. XM_006540583.5 → XP_006540646.1  phospholipid-transporting ATPase VA isoform X4

      Conserved Domains (1) summary
      cd02073
      Location:258 → 763
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    5. XM_017321952.3 → XP_017177441.1  phospholipid-transporting ATPase VA isoform X3

      Conserved Domains (1) summary
      cd02073
      Location:1 → 835
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    RNA

    1. XR_882009.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54827.4 GenPept UniProtKB/Swiss-Prot:O54827

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