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    Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 [ Mus musculus (house mouse) ]

    Gene ID: 67264, updated on 5-Apr-2024

    Summary

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    Official Symbol
    Ndufb8provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit B8provided by MGI
    Primary source
    MGI:MGI:1914514
    See related
    Ensembl:ENSMUSG00000025204 AllianceGenome:MGI:1914514
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CI-ASHI; 2900010I05Rik
    Summary
    Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of mitochondrial respiratory chain complex I. Is expressed in several structures, including alimentary system; integumental system; nervous system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 32. Orthologous to human NDUFB8 (NADH:ubiquinone oxidoreductase subunit B8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 237.7), kidney adult (RPKM 174.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 C3; 19 37.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44537010..44543881, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44548571..44555442, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene wingless-type MMTV integration site family, member 8B Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:44587253-44587525 Neighboring gene SEC31 homolog B, COPII coat complex component Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:44637138-44637321 Neighboring gene hypoxia-inducible factor 1, alpha subunit inhibitor Neighboring gene STARR-seq mESC enhancer starr_46238 Neighboring gene predicted gene, 35460

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reduced levels of mitochondrial complex I subunit NDUFB8 and linked complex I + III oxidoreductase activity in the TgCRND8 mouse model of Alzheimer's disease. Francis BM, et al. J Alzheimers Dis, 2014. PMID 24217272
    2. Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis. Hangen E, et al. Mol Cell, 2015 Jun 18. PMID 26004228
    3. A concerted metabolic shift in early forebrain alters the CSF proteome and depends on MYC downregulation for mitochondrial maturation. Fame RM, et al. Development, 2019 Oct 24. PMID 31575649, Free PMC Article
    4. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Odegaard JI, et al. Cell, 2016 Aug 11. PMID 27453471, Free PMC Article
    5. FBXL4 deficiency increases mitochondrial removal by autophagy. Alsina D, et al. EMBO Mol Med, 2020 Jul 7. PMID 32525278, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study reports mitochondrial dysfunction in TgCRND8 mouse model of Alzheimer's disease and identifies the NDUFB8 subunit of complex I as a key target of A-beta toxicity
      Title: Reduced levels of mitochondrial complex I subunit NDUFB8 and linked complex I + III oxidoreductase activity in the TgCRND8 mouse model of Alzheimer's disease.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, NADH to ubiquinone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in respirasome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
    Names
    NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8
    NADH-ubiquinone oxidoreductase ASHI subunit
    complex I-ASHI
    NP_001334376.1
    NP_080337.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347447.1 → NP_001334376.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC151478
      Consensus CDS
      CCDS84446.1
      UniProtKB/TrEMBL
      Q3V406
      Related
      ENSMUSP00000128192.2, ENSMUST00000171415.8

    2. NM_026061.3 → NP_080337.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_080337.1

      Status: VALIDATED

      Source sequence(s)
      AC151478
      Consensus CDS
      CCDS29851.1
      UniProtKB/Swiss-Prot
      Q9D6J5, Q9D6M7
      Related
      ENSMUSP00000026222.5, ENSMUST00000026222.11
      Conserved Domains (1) summary
      pfam05821
      Location:21 → 186
      NDUF_B8; NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      44537010..44543881 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D6J5.1 GenPept UniProtKB/Swiss-Prot:Q9D6J5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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