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    Mms19 MMS19 cytosolic iron-sulfur assembly component [ Mus musculus (house mouse) ]

    Gene ID: 72199, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mms19provided by MGI
    Official Full Name
    MMS19 cytosolic iron-sulfur assembly componentprovided by MGI
    Primary source
    MGI:MGI:1919449
    See related
    Ensembl:ENSMUSG00000025159 AllianceGenome:MGI:1919449
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mms19l; 2410001K24Rik; 2610042O15Rik
    Summary
    Enables enzyme binding activity. Predicted to be involved in several processes, including iron-sulfur cluster assembly; positive regulation of nucleobase-containing compound metabolic process; and protein maturation by iron-sulfur cluster transfer. Predicted to be located in cytosol; nucleoplasm; and spindle. Predicted to be part of CIA complex and MMXD complex. Is expressed in several structures, including apical ectodermal ridge; liver; nervous system; neural retina; and trunk somite. Orthologous to human MMS19 (MMS19 homolog, cytosolic iron-sulfur assembly component). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 24.9), ovary adult (RPKM 20.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 C3; 19 35.49 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (41932146..41969603, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (41943707..41981164, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7659 Neighboring gene phosphoglycerate mutase 1 Neighboring gene STARR-positive B cell enhancer ABC_E3252 Neighboring gene exosome component 1 Neighboring gene zinc finger, DHHC domain containing 16 Neighboring gene STARR-positive B cell enhancer ABC_E1524 Neighboring gene predicted gene, 23113 Neighboring gene ubiquitin domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_46168 Neighboring gene STARR-seq mESC enhancer starr_46171 Neighboring gene ankyrin repeat domain 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mms19 protein functions in nucleotide excision repair by sustaining an adequate cellular concentration of the TFIIH component Rad3. Kou H, et al. Proc Natl Acad Sci U S A, 2008 Oct 14. PMID 18836076, Free PMC Article
    2. Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant. Queimado L, et al. Nucleic Acids Res, 2001 May 1. PMID 11328871, Free PMC Article
    3. The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly. van Wietmarschen N, et al. J Biol Chem, 2012 Dec 21. PMID 23150669, Free PMC Article
    4. RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication. Vannier JB, et al. Science, 2013 Oct 11. PMID 24115439
    5. MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism. Gari K, et al. Science, 2012 Jul 13. PMID 22678361

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly.
      Title: The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly.
    2. in the absence of MMS19, a failure to transfer Fe-S clusters to target proteins is associated with Fe-S protein instability and preimplantation death of mice in which Mms19 has been knocked out; propose that MMS19 functions as a platform to facilitate Fe-S cluster transfer to proteins critical for DNA replication and repair
      Title: MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.
    3. Mms19 has distinct and separable functions in nucleotide excision repair and cell growth
      Title: Mms19 protein functions in nucleotide excision repair by sustaining an adequate cellular concentration of the TFIIH component Rad3.
    4. Cloning of the mouse MMS19 genes and functional complementation in Saccharomyces cerevisiae
      Title: Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CIA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CIA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MMXD complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MMXD complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MMS19 nucleotide excision repair protein homolog
    Names
    MET18 homolog
    MMS19 (MET18 S. cerevisiae)
    MMS19-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001373946.1 → NP_001360875.1  MMS19 nucleotide excision repair protein homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140193
      UniProtKB/TrEMBL
      F7C9N6
      Related
      ENSMUSP00000026168.3, ENSMUST00000026168.9
      Conserved Domains (2) summary
      pfam12460
      Location:527 → 962
      MMS19_C; RNAPII transcription regulator C-terminal
      pfam14500
      Location:54 → 312
      MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

    2. NM_028152.3 → NP_082428.1  MMS19 nucleotide excision repair protein homolog isoform 1

      See identical proteins and their annotated locations for NP_082428.1

      Status: VALIDATED

      Source sequence(s)
      AC140193
      Consensus CDS
      CCDS29818.1
      UniProtKB/Swiss-Prot
      F8WHX3, Q925N8, Q9CWX3, Q9D071
      UniProtKB/TrEMBL
      F7C9N6
      Related
      ENSMUSP00000130900.2, ENSMUST00000171561.8
      Conserved Domains (2) summary
      pfam12460
      Location:528 → 963
      MMS19_C; RNAPII transcription regulator C-terminal
      pfam14500
      Location:54 → 312
      MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

    RNA

    1. NR_164197.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC140193
      Related
      ENSMUST00000163398.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      41932146..41969603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247350.3 → XP_011245652.1  MMS19 nucleotide excision repair protein homolog isoform X2

      UniProtKB/TrEMBL
      F7C9N6
      Conserved Domains (2) summary
      pfam12460
      Location:374 → 809
      MMS19_C; RNAPII transcription regulator C-terminal
      pfam14500
      Location:26 → 158
      MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

    2. XM_030251078.2 → XP_030106938.1  MMS19 nucleotide excision repair protein homolog isoform X5

      Conserved Domains (1) summary
      pfam12460
      Location:163 → 598
      MMS19_C; RNAPII transcription regulator C-terminal

    3. XM_030251082.2 → XP_030106942.1  MMS19 nucleotide excision repair protein homolog isoform X6

      Conserved Domains (1) summary
      pfam12460
      Location:162 → 597
      MMS19_C; RNAPII transcription regulator C-terminal

    4. XM_030251081.2 → XP_030106941.1  MMS19 nucleotide excision repair protein homolog isoform X5

      Conserved Domains (1) summary
      pfam12460
      Location:163 → 598
      MMS19_C; RNAPII transcription regulator C-terminal

    5. XM_030251080.1 → XP_030106940.1  MMS19 nucleotide excision repair protein homolog isoform X5

      Conserved Domains (1) summary
      pfam12460
      Location:163 → 598
      MMS19_C; RNAPII transcription regulator C-terminal

    6. XM_030251079.1 → XP_030106939.1  MMS19 nucleotide excision repair protein homolog isoform X5

      Conserved Domains (1) summary
      pfam12460
      Location:163 → 598
      MMS19_C; RNAPII transcription regulator C-terminal

    7. XM_011247349.4 → XP_011245651.1  MMS19 nucleotide excision repair protein homolog isoform X1

      See identical proteins and their annotated locations for XP_011245651.1

      UniProtKB/TrEMBL
      F7C9N6
      Related
      ENSMUST00000171755.8
      Conserved Domains (2) summary
      pfam12460
      Location:528 → 886
      MMS19_C; RNAPII transcription regulator C-terminal
      pfam14500
      Location:54 → 312
      MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

    8. XM_011247348.4 → XP_011245650.1  MMS19 nucleotide excision repair protein homolog isoform X1

      See identical proteins and their annotated locations for XP_011245650.1

      UniProtKB/TrEMBL
      F7C9N6
      Conserved Domains (2) summary
      pfam12460
      Location:528 → 886
      MMS19_C; RNAPII transcription regulator C-terminal
      pfam14500
      Location:54 → 312
      MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

    9. XM_017318292.3 → XP_017173781.1  MMS19 nucleotide excision repair protein homolog isoform X4

      Conserved Domains (2) summary
      pfam12460
      Location:527 → 804
      MMS19_C; RNAPII transcription regulator C-terminal
      pfam14500
      Location:54 → 312
      MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

    10. XM_011247351.4 → XP_011245653.1  MMS19 nucleotide excision repair protein homolog isoform X3

      Conserved Domains (2) summary
      pfam12460
      Location:528 → 805
      MMS19_C; RNAPII transcription regulator C-terminal
      pfam14500
      Location:54 → 312
      MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

    RNA

    1. XR_001782617.3 RNA Sequence

    2. XR_001782619.3 RNA Sequence

    3. XR_001782618.3 RNA Sequence

      Related
      ENSMUST00000164776.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D071.1 GenPept UniProtKB/Swiss-Prot:Q9D071

    Gene LinkOut

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