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    Zdhhc16 zinc finger, DHHC domain containing 16 [ Mus musculus (house mouse) ]

    Gene ID: 74168, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zdhhc16provided by MGI
    Official Full Name
    zinc finger, DHHC domain containing 16provided by MGI
    Primary source
    MGI:MGI:1921418
    See related
    Ensembl:ENSMUSG00000025157 AllianceGenome:MGI:1921418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aph2; 1500015N03Rik
    Summary
    Enables palmitoyltransferase activity. Involved in animal organ development; cellular response to DNA damage stimulus; and protein palmitoylation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in early conceptus; eye; genitourinary system; heart; and trunk somite. Orthologous to human ZDHHC16 (zinc finger DHHC-type palmitoyltransferase 16). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 18.4), ovary adult (RPKM 16.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 C3; 19 35.48 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (41921884..41932543)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (41933445..41944104)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7659 Neighboring gene phosphoglycerate mutase 1 Neighboring gene exosome component 1 Neighboring gene STARR-positive B cell enhancer ABC_E3252 Neighboring gene MMS19 cytosolic iron-sulfur assembly component Neighboring gene STARR-positive B cell enhancer ABC_E1524 Neighboring gene predicted gene, 23113 Neighboring gene ubiquitin domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_46168 Neighboring gene STARR-seq mESC enhancer starr_46171

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A potential role for protein palmitoylation and zDHHC16 in DNA damage response. Cao N, et al. BMC Mol Biol, 2016 May 10. PMID 27159997, Free PMC Article
    2. Local Palmitoylation Cycles and Specialized Membrane Domain Organization. Fukata Y, et al. Curr Top Membr, 2016. PMID 26781831
    3. Mechanistic effects of protein palmitoylation and the cellular consequences thereof. Blaskovic S, et al. Chem Phys Lipids, 2014 May. PMID 24534427
    4. Palmitoylation and the trafficking of peripheral membrane proteins. Chamberlain LH, et al. Biochem Soc Trans, 2013 Feb 1. PMID 23356259
    5. Palmitoylation and depalmitoylation dynamics at a glance. Conibear E, et al. J Cell Sci, 2010 Dec 1. PMID 21084560, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockout of zDHHC16, a palmitoyltransferase gene is identified as an interacting protein for c-Abl, a non-receptor tyrosine kinase involved in DNA damage response, reproduced most of the defects in DNA damage responses produced by the inhibition of protein palmitoylation.
      Title: A potential role for protein palmitoylation and zDHHC16 in DNA damage response.
    2. Aph2 as a critical in vivo regulator of cardiac function and reveal roles for protein palmitoylation in the development of other organs including eyes.
      Title: Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy.
    3. Aph2 may be involved in ER stress-induced apoptosis in which c-Abl plays an important role
      Title: Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC16
    Names
    Abl-philin 2
    ablphilin-2
    probable palmitoyltransferase ZDHHC16
    zinc finger DHHC domain-containing protein 16
    NP_001347605.1
    NP_001347608.1
    NP_076229.2
    XP_006527467.1
    XP_006527468.1
    XP_006527469.1
    XP_006527470.1
    XP_017173789.1
    XP_030106976.1
    XP_030106977.1
    XP_030106978.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360676.1 → NP_001347605.1  palmitoyltransferase ZDHHC16 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC140193
      Conserved Domains (1) summary
      pfam01529
      Location:156 → 305
      DHHC; DHHC palmitoyltransferase

    2. NM_001360679.1 → NP_001347608.1  palmitoyltransferase ZDHHC16 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC140193
      Conserved Domains (1) summary
      pfam01529
      Location:1 → 109
      DHHC; DHHC palmitoyltransferase

    3. NM_023740.3 → NP_076229.2  palmitoyltransferase ZDHHC16 isoform 2

      See identical proteins and their annotated locations for NP_076229.2

      Status: VALIDATED

      Source sequence(s)
      AK151505, BY634308, CK619221, DV658063
      Consensus CDS
      CCDS29817.1
      UniProtKB/Swiss-Prot
      Q3TI22, Q3UA59, Q91XC5, Q9ESG8
      Related
      ENSMUSP00000026154.8, ENSMUST00000026154.9
      Conserved Domains (1) summary
      pfam01529
      Location:156 → 289
      DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      41921884..41932543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527406.4 → XP_006527469.1  palmitoyltransferase ZDHHC16 isoform X4

      See identical proteins and their annotated locations for XP_006527469.1

      Conserved Domains (1) summary
      pfam01529
      Location:1 → 125
      DHHC; DHHC palmitoyltransferase

    2. XM_006527407.4 → XP_006527470.1  palmitoyltransferase ZDHHC16 isoform X4

      See identical proteins and their annotated locations for XP_006527470.1

      Conserved Domains (1) summary
      pfam01529
      Location:1 → 125
      DHHC; DHHC palmitoyltransferase

    3. XM_030251118.2 → XP_030106978.1  palmitoyltransferase ZDHHC16 isoform X5

      Conserved Domains (1) summary
      pfam01529
      Location:1 → 109
      DHHC; DHHC palmitoyltransferase

    4. XM_017318300.3 → XP_017173789.1  palmitoyltransferase ZDHHC16 isoform X1

      Conserved Domains (1) summary
      pfam01529
      Location:156 → 305
      DHHC; DHHC palmitoyltransferase

    5. XM_030251117.2 → XP_030106977.1  palmitoyltransferase ZDHHC16 isoform X2

      Conserved Domains (1) summary
      pfam01529
      Location:156 → 289
      DHHC; DHHC palmitoyltransferase

    6. XM_006527404.5 → XP_006527467.1  palmitoyltransferase ZDHHC16 isoform X1

      Conserved Domains (1) summary
      pfam01529
      Location:156 → 305
      DHHC; DHHC palmitoyltransferase

    7. XM_030251116.2 → XP_030106976.1  palmitoyltransferase ZDHHC16 isoform X2

      Conserved Domains (1) summary
      pfam01529
      Location:156 → 289
      DHHC; DHHC palmitoyltransferase

    8. XM_006527405.5 → XP_006527468.1  palmitoyltransferase ZDHHC16 isoform X3

      Conserved Domains (1) summary
      cl19890
      Location:156 → 194
      DHHC; DHHC palmitoyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ESG8.2 GenPept UniProtKB/Swiss-Prot:Q9ESG8

    Gene LinkOut

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