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    Arhgap19 Rho GTPase activating protein 19 [ Mus musculus (house mouse) ]

    Gene ID: 71085, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Arhgap19provided by MGI
    Official Full Name
    Rho GTPase activating protein 19provided by MGI
    Primary source
    MGI:MGI:1918335
    See related
    Ensembl:ENSMUSG00000025154 AllianceGenome:MGI:1918335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mFLJ00368; 4933411B03Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including gut; male reproductive gland or organ; and trigeminal nerve. Orthologous to human ARHGAP19 (Rho GTPase activating protein 19). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 16.1), testis adult (RPKM 15.6) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 C3; 19 35.19 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (41755027..41790523, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (41766588..41802084, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene slit guidance ligand 1 Neighboring gene predicted gene, 34116 Neighboring gene VISTA enhancer mm1552 Neighboring gene predicted gene, 19424 Neighboring gene STARR-seq mESC enhancer starr_46160 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:41843349-41843458 Neighboring gene STARR-seq mESC enhancer starr_46161 Neighboring gene STARR-positive B cell enhancer ABC_E7656 Neighboring gene predicted gene, 41847 Neighboring gene STARR-positive B cell enhancer ABC_E7657 Neighboring gene STARR-seq mESC enhancer starr_46163 Neighboring gene frequently rearranged in advanced T cell lymphomas

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. What Goes Around Can Come Around: An Unexpected Deleterious Effect of Using Mouse Running Wheels for Environmental Enrichment. Leduc RY, et al. J Am Assoc Lab Anim Sci, 2017 Mar 1. PMID 28315651, Free PMC Article
    2. Regulation of ARHGAP19 in the endometrial epithelium: a possible role in the establishment of uterine receptivity. Liang J, et al. Reprod Biol Endocrinol, 2021 Jan 7. PMID 33407571, Free PMC Article
    3. Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes. Kooistra MK, et al. Physiol Genomics, 2012 Jan 18. PMID 22045912
    4. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of ARHGAP19 in the endometrial epithelium: a possible role in the establishment of uterine receptivity.
      Title: Regulation of ARHGAP19 in the endometrial epithelium: a possible role in the establishment of uterine receptivity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1)  1 citation
    • Gene trapped (1) 
    • Targeted (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ00368

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 19
    Names
    rho-type GTPase-activating protein 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163495.1 → NP_001156967.1  rho GTPase-activating protein 19 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, compared to variant 1, that causes a frameshift. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC145557, BC086680
      Consensus CDS
      CCDS50435.1
      UniProtKB/TrEMBL
      E9Q4T1
      Related
      ENSMUSP00000129586.2, ENSMUST00000163265.9
      Conserved Domains (1) summary
      cd04392
      Location:113 → 320
      RhoGAP_ARHGAP19; RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

    2. NM_027667.3 → NP_081943.2  rho GTPase-activating protein 19 isoform 1

      See identical proteins and their annotated locations for NP_081943.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC145557, BC086680
      Consensus CDS
      CCDS37989.1
      UniProtKB/Swiss-Prot
      B9EI55, Q0VGS7, Q5DU53, Q8BRH3, Q9D468
      Related
      ENSMUSP00000026150.9, ENSMUST00000026150.15
      Conserved Domains (1) summary
      cd04392
      Location:113 → 320
      RhoGAP_ARHGAP19; RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      41755027..41790523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161690.1 → XP_036017583.1  rho GTPase-activating protein 19 isoform X6

      Conserved Domains (1) summary
      cd04392
      Location:107 → 293
      RhoGAP_ARHGAP19; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...

    2. XM_036161689.1 → XP_036017582.1  rho GTPase-activating protein 19 isoform X5

    3. XM_011247341.2 → XP_011245643.1  rho GTPase-activating protein 19 isoform X1

      Conserved Domains (1) summary
      cd04392
      Location:104 → 311
      RhoGAP_ARHGAP19; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...

    4. XM_011247343.2 → XP_011245645.1  rho GTPase-activating protein 19 isoform X3

      Conserved Domains (1) summary
      cd04392
      Location:104 → 311
      RhoGAP_ARHGAP19; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...

    5. XM_011247342.2 → XP_011245644.1  rho GTPase-activating protein 19 isoform X2

      Conserved Domains (1) summary
      cd04392
      Location:104 → 311
      RhoGAP_ARHGAP19; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...

    6. XM_011247344.4 → XP_011245646.3  rho GTPase-activating protein 19 isoform X4

      Conserved Domains (1) summary
      cd04392
      Location:98 → 284
      RhoGAP_ARHGAP19; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BRH3.2 GenPept UniProtKB/Swiss-Prot:Q8BRH3

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