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    Tollip toll interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 54473, updated on 16-Apr-2024

    Summary

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    Official Symbol
    Tollipprovided by MGI
    Official Full Name
    toll interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1891808
    See related
    Ensembl:ENSMUSG00000025139 AllianceGenome:MGI:1891808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930403G24Rik; 4931428G15Rik
    Summary
    Predicted to enable enzyme binding activity; signaling receptor binding activity; and ubiquitin-like protein binding activity. Involved in interleukin-1-mediated signaling pathway. Part of protein-containing complex. Is expressed in ovary; renal interstitium; renal vasculature; and testis. Orthologous to human TOLLIP (toll interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 75.3), cerebellum adult (RPKM 36.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F5; 7 87.34 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141435317..141456198, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141881580..141902461, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene mucin 5, subtypes A and C, tracheobronchial/gastric Neighboring gene STARR-seq mESC enhancer starr_20496 Neighboring gene mucin 5, subtype B, tracheobronchial Neighboring gene STARR-seq mESC enhancer starr_20497 Neighboring gene predicted gene, 32539 Neighboring gene BR serine/threonine kinase 2 Neighboring gene microRNA 3104

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tollip Orchestrates Macrophage Polarization to Alleviate Intestinal Mucosal Inflammation. Liu X, et al. J Crohns Colitis, 2022 Aug 4. PMID 35134154
    2. Protective effect of toll-interacting protein overexpression against paraquat-induced lung injury in mice and A549 cells through inhibiting oxidative stress, inflammation, and NF-κB signaling pathway. Zheng Q, et al. Respir Physiol Neurobiol, 2021 Apr. PMID 33333238
    3. Toll-Interacting Protein Regulates Immune Cell Infiltration and Promotes Colitis-Associated Cancer. Begka C, et al. iScience, 2020 Mar 27. PMID 32114379, Free PMC Article
    4. TOLLIP deficiency is associated with increased resistance to Legionella pneumophila pneumonia. Shah JA, et al. Mucosal Immunol, 2019 Nov. PMID 31462698, Free PMC Article
    5. Enhanced tumor immune surveillance through neutrophil reprogramming due to Tollip deficiency. Zhang Y, et al. JCI Insight, 2019 Jan 24. PMID 30674719, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TOLLIP inhibits lipid accumulation and the integrated stress response in alveolar macrophages to control Mycobacterium tuberculosis infection.
      Title: TOLLIP inhibits lipid accumulation and the integrated stress response in alveolar macrophages to control Mycobacterium tuberculosis infection.
    2. Tollip Inhibits IL-33 Release and Inflammation in Influenza A Virus-Infected Mouse Airways.
      Title: Tollip Inhibits IL-33 Release and Inflammation in Influenza A Virus-Infected Mouse Airways.
    3. BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP phosphorylation.
      Title: BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP phosphorylation.
    4. Tollip Orchestrates Macrophage Polarization to Alleviate Intestinal Mucosal Inflammation.
      Title: Tollip Orchestrates Macrophage Polarization to Alleviate Intestinal Mucosal Inflammation.
    5. TOLLIP Optimizes Dendritic Cell Maturation to Lipopolysaccharide and Mycobacterium tuberculosis.
      Title: TOLLIP Optimizes Dendritic Cell Maturation to Lipopolysaccharide and Mycobacterium tuberculosis.
    6. PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip.
      Title: PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip.
    7. Protective effect of toll-interacting protein overexpression against paraquat-induced lung injury in mice and A549 cells through inhibiting oxidative stress, inflammation, and NF-kappaB signaling pathway.
      Title: Protective effect of toll-interacting protein overexpression against paraquat-induced lung injury in mice and A549 cells through inhibiting oxidative stress, inflammation, and NF-κB signaling pathway.
    8. Toll-Interacting Protein in Pulmonary Diseases. Abiding by the Goldilocks Principle.
      Title: Toll-Interacting Protein in Pulmonary Diseases. Abiding by the Goldilocks Principle.
    9. TOLLIP decreases lung-specific TLR responses to increase susceptibility to Legionella pneumophila pneumonia.
      Title: TOLLIP deficiency is associated with increased resistance to Legionella pneumophila pneumonia.
    10. our findings reveal that resting-state STING protein level is strictly regulated by a constant tug-of-war between 'stabilizer' TOLLIP and 'degrader' IRE1alpha-lysosome that together maintain tissue immune homeostasis
      Title: Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Toll-like receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-1, type I receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-1-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    toll-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347562.1 → NP_001334491.1  toll-interacting protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL772165
      Consensus CDS
      CCDS85459.1
      UniProtKB/TrEMBL
      F7AT44, Q8BQL7
      Related
      ENSMUSP00000117938.3, ENSMUST00000130439.3
      Conserved Domains (2) summary
      cd04016
      Location:48 → 168
      C2_Tollip; C2 domain present in Toll-interacting protein (Tollip)
      cd14363
      Location:226 → 266
      CUE_TOLIP; CUE domain found in the C-terminal of toll-interacting protein (Tollip) and similar proteins

    2. NM_023764.4 → NP_076253.1  toll-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_076253.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK016482, AL772165, CF171126
      Consensus CDS
      CCDS22020.1
      UniProtKB/Swiss-Prot
      Q543N1, Q9D5P5, Q9QZ06
      UniProtKB/TrEMBL
      Q8BQL7
      Related
      ENSMUSP00000001950.6, ENSMUST00000001950.12
      Conserved Domains (2) summary
      cd04016
      Location:52 → 172
      C2_Tollip; C2 domain present in Toll-interacting protein (Tollip)
      cd14363
      Location:230 → 270
      CUE_TOLIP; CUE domain found in the C-terminal of toll-interacting protein (Tollip) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      141435317..141456198 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZ06.1 GenPept UniProtKB/Swiss-Prot:Q9QZ06

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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