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    Plaat5 phospholipase A and acyltransferase 5 [ Mus musculus (house mouse) ]

    Gene ID: 66727, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Plaat5provided by MGI
    Official Full Name
    phospholipase A and acyltransferase 5provided by MGI
    Primary source
    MGI:MGI:1913977
    See related
    Ensembl:ENSMUSG00000024973 AllianceGenome:MGI:1913977
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    iNAT; HRSL5; Hrasls5; 1700055A14Rik; 1700086E08Rik; 4921526K24Rik
    Summary
    Enables N-acyltransferase activity. Acts upstream of or within N-acylphosphatidylethanolamine metabolic process. Predicted to be active in cytoplasm. Orthologous to human PLAAT5 (phospholipase A and acyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 836.0) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 A; 19 5.33 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (7589902..7618405)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (7612537..7641040)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene phospholipase A and acyltransferase 3 Neighboring gene STARR-seq mESC enhancer starr_45469 Neighboring gene STARR-seq mESC enhancer starr_45470 Neighboring gene lectin, galactose binding, soluble 12 Neighboring gene IscU iron-sulfur cluster scaffold homolog pseudogene Neighboring gene solute carrier family 22 (organic anion transporter), member 19 Neighboring gene Yamaguchi sarcoma viral (v-yes) oncogene homolog 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning and characterization of human and mouse Ca(2+)-independent phosphatidylethanolamine N-acyltransferases. Jin XH, et al. Biochim Biophys Acta, 2009 Jan. PMID 19000777
    2. Discovery and characterization of a Ca2+-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners. Jin XH, et al. J Biol Chem, 2007 Feb 9. PMID 17158102
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-acyl-2-lysophosphatidylserine acylhydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylserine 1-acylhydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase A1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase A1 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acylphosphatidylethanolamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within N-acylphosphatidylethanolamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within N-acylphosphatidylethanolamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in N-acylphosphatidylethanolamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipase A and acyltransferase 5
    Names
    Ca(2+)-independent N-acyltransferase
    Ca-independent N-acyltransferase
    H-rev107-like protein 5
    HRAS-like suppressor 5
    HRAS-like suppressor family, member 5
    NP_001355625.1
    NP_080007.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368696.1 → NP_001355625.1  phospholipase A and acyltransferase 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109225, AK006790
      UniProtKB/TrEMBL
      D3YZK9
      Related
      ENSMUSP00000118096.3, ENSMUST00000148558.3
      Conserved Domains (1) summary
      pfam04970
      Location:134 → 236
      LRAT; Lecithin retinol acyltransferase

    2. NM_025731.3 → NP_080007.2  phospholipase A and acyltransferase 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC109225, AK014971
      Consensus CDS
      CCDS29530.1
      UniProtKB/Swiss-Prot
      Q6P8Y6, Q9CPX5, Q9CVQ2, Q9CVS0
      Related
      ENSMUSP00000025929.6, ENSMUST00000025929.12
      Conserved Domains (1) summary
      pfam04970
      Location:134 → 236
      LRAT; Lecithin retinol acyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      7589902..7618405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPX5.2 GenPept UniProtKB/Swiss-Prot:Q9CPX5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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