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    Dnajc4 DnaJ heat shock protein family (Hsp40) member C4 [ Mus musculus (house mouse) ]

    Gene ID: 57431, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Dnajc4provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C4provided by MGI
    Primary source
    MGI:MGI:1927346
    See related
    Ensembl:ENSMUSG00000024963 AllianceGenome:MGI:1927346
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hspf2; Mcg18
    Summary
    Located in mitochondrion. Orthologous to human DNAJC4 (DnaJ heat shock protein family (Hsp40) member C4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 41.6), colon adult (RPKM 24.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnajc4 in Genome Data Viewer
    Location:
    19 A; 19 5.13 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6965279..6969954, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6987911..6992591, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51400 Neighboring gene FK506 binding protein 2 Neighboring gene predicted gene, 54053 Neighboring gene vascular endothelial growth factor B Neighboring gene STARR-positive B cell enhancer ABC_E1971 Neighboring gene nudix hydrolase 22 Neighboring gene tRNA phosphotransferase 1 Neighboring gene fermitin family member 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7092729-7092882 Neighboring gene predicted gene, 54052

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterisation of a new human and murine member of the DnaJ family of proteins. Silins G, et al. Biochem Biophys Res Commun, 1998 Feb 4. PMID 9473517
    2. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. Ohtsuka K, et al. Cell Stress Chaperones, 2000 Apr. PMID 11147971, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • 2010301J22Rik

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 4
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 4
    heat shock 40kD protein 2
    multiple endocrine neoplasia type 1 candidate protein 18
    multiple endocrine neoplasia type 1 candidate protein number 18 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356999.1 → NP_001343928.1  dnaJ homolog subfamily C member 4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC120557, AK008507
      Consensus CDS
      CCDS89329.1
      UniProtKB/TrEMBL
      K3W4M1
      Related
      ENSMUSP00000025915.7, ENSMUST00000025915.13
      Conserved Domains (1) summary
      pfam00226
      Location:53 → 115
      DnaJ; DnaJ domain

    2. NM_001357000.1 → NP_001343929.1  dnaJ homolog subfamily C member 4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC120557
      Consensus CDS
      CCDS89329.1
      UniProtKB/TrEMBL
      K3W4M1
      Conserved Domains (1) summary
      pfam00226
      Location:53 → 115
      DnaJ; DnaJ domain

    3. NM_001357001.1 → NP_001343930.1  dnaJ homolog subfamily C member 4 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC120557
      UniProtKB/TrEMBL
      Q6GTN1
      Conserved Domains (1) summary
      pfam00226
      Location:37 → 99
      DnaJ; DnaJ domain

    4. NM_001414717.1 → NP_001401646.1  dnaJ homolog subfamily C member 4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC120557
      UniProtKB/TrEMBL
      K3W4M1

    5. NM_001414718.1 → NP_001401647.1  dnaJ homolog subfamily C member 4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC120557
      UniProtKB/TrEMBL
      K3W4M1

    6. NM_001414719.1 → NP_001401648.1  dnaJ homolog subfamily C member 4 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC120557

    7. NM_001414720.1 → NP_001401649.1  dnaJ homolog subfamily C member 4 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC120557
      UniProtKB/TrEMBL
      Q6GTN1

    8. NM_020566.2 → NP_065591.1  dnaJ homolog subfamily C member 4 isoform c

      See identical proteins and their annotated locations for NP_065591.1

      Status: VALIDATED

      Source sequence(s)
      AC120557, AF036875
      Consensus CDS
      CCDS50374.1
      UniProtKB/Swiss-Prot
      O70278, Q9D844
      Related
      ENSMUSP00000136062.2, ENSMUST00000179118.2
      Conserved Domains (2) summary
      COG0484
      Location:35 → 99
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:37 → 99
      DnaJ; DnaJ domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6965279..6969954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D844.2 GenPept UniProtKB/Swiss-Prot:Q9D844

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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