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    Vegfb vascular endothelial growth factor B [ Mus musculus (house mouse) ]

    Gene ID: 22340, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Vegfbprovided by MGI
    Official Full Name
    vascular endothelial growth factor Bprovided by MGI
    Primary source
    MGI:MGI:106199
    See related
    Ensembl:ENSMUSG00000024962 AllianceGenome:MGI:106199
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vrf; VEGF-B
    Summary
    Enables identical protein binding activity. Acts upstream of or within cardiac muscle contraction; coronary vasculature development; and protein O-linked glycosylation. Located in extracellular region. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and musculoskeletal system. Human ortholog(s) of this gene implicated in myocardial infarction and pulmonary hypertension. Orthologous to human VEGFB (vascular endothelial growth factor B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in heart adult (RPKM 99.0), adrenal adult (RPKM 88.4) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vegfb in Genome Data Viewer
    Location:
    19 A; 19 5.12 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6959840..6965019, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6982472..6987651, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7050464-7050926 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 14B Neighboring gene predicted gene, 51400 Neighboring gene FK506 binding protein 2 Neighboring gene predicted gene, 54053 Neighboring gene DnaJ heat shock protein family (Hsp40) member C4 Neighboring gene STARR-positive B cell enhancer ABC_E1971 Neighboring gene tRNA phosphotransferase 1 Neighboring gene nudix hydrolase 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of adipose tissue development and energy metabolism by VEGFB isoforms. Chen Y, et al. J Endocrinol, 2023 Jul 1. PMID 37074365
    2. Reducing VEGFB accelerates NAFLD and insulin resistance in mice via inhibiting AMPK signaling pathway. Li R, et al. J Transl Med, 2022 Jul 30. PMID 35907871, Free PMC Article
    3. Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium. Lähteenvuo J, et al. Mol Ther, 2020 Jul 8. PMID 32243833, Free PMC Article
    4. VEGF-B ablation in pancreatic β-cells upregulates insulin expression without affecting glucose homeostasis or islet lipid uptake. Ning FC, et al. Sci Rep, 2020 Jan 22. PMID 31969592, Free PMC Article
    5. Adipose vascular endothelial growth factor B is a major regulator of energy metabolism. Chen Y, et al. J Endocrinol, 2020 Mar. PMID 31910156

    See all (117) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of adipose tissue development and energy metabolism by VEGFB isoforms.
      Title: Regulation of adipose tissue development and energy metabolism by VEGFB isoforms.
    2. Reducing VEGFB accelerates NAFLD and insulin resistance in mice via inhibiting AMPK signaling pathway.
      Title: Reducing VEGFB accelerates NAFLD and insulin resistance in mice via inhibiting AMPK signaling pathway.
    3. Knockdown of VEGFB/VEGFR1 Signaling Promotes White Adipose Tissue Browning and Skeletal Muscle Development.
      Title: Knockdown of VEGFB/VEGFR1 Signaling Promotes White Adipose Tissue Browning and Skeletal Muscle Development.
    4. Reducing VEGFB expression regulates the balance of glucose and lipid metabolism in mice via VEGFR1.
      Title: Reducing VEGFB expression regulates the balance of glucose and lipid metabolism in mice via VEGFR1.
    5. VEGFB Promotes Myoblasts Proliferation and Differentiation through VEGFR1-PI3K/Akt Signaling Pathway.
      Title: VEGFB Promotes Myoblasts Proliferation and Differentiation through VEGFR1-PI3K/Akt Signaling Pathway.
    6. Class A1 scavenger receptor prevents obesity-associated blood pressure elevation through suppressing overproduction of vascular endothelial growth factor B in macrophages.
      Title: Class A1 scavenger receptor prevents obesity-associated blood pressure elevation through suppressing overproduction of vascular endothelial growth factor B in macrophages.
    7. Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium.
      Title: Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium.
    8. VEGF-B ablation in pancreatic beta-cells upregulates insulin expression without affecting glucose homeostasis or islet lipid uptake.
      Title: VEGF-B ablation in pancreatic β-cells upregulates insulin expression without affecting glucose homeostasis or islet lipid uptake.
    9. Adipose vascular endothelial growth factor B is a major regulator of energy metabolism.
      Title: Adipose vascular endothelial growth factor B is a major regulator of energy metabolism.
    10. VEGF and VEGFB counteractively regulate adipose development and function in energy metabolism.
      Title: VEGF and VEGFB Play Balancing Roles in Adipose Differentiation, Gene Expression, and Function.
    Submit: New GeneRIF Correction See all GeneRIFs (39)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (4)  1 citation
    • Endonuclease-mediated (5) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chemoattractant activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chemoattractant activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables vascular endothelial growth factor receptor 1 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables vascular endothelial growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in induction of positive chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in induction of positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of endothelial cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mast cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mast cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vascular wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein O-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vascular endothelial growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vascular endothelial growth factor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vascular endothelial growth factor B
    Names
    VEGF-related factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001185164.1 → NP_001172093.1  vascular endothelial growth factor B isoform Vegf-b167 precursor

      See identical proteins and their annotated locations for NP_001172093.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. This difference results in a frameshift and an isoform (Vegf-b167) with a shorter and distinct C-terminus, compared to isoform Vegf-b186.
      Source sequence(s)
      AK148188, BC046303, CF804631
      Consensus CDS
      CCDS50373.1
      UniProtKB/Swiss-Prot
      P49766
      Related
      ENSMUSP00000120860.2, ENSMUST00000130048.8
      Conserved Domains (1) summary
      smart00141
      Location:45 → 126
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

    2. NM_011697.3 → NP_035827.1  vascular endothelial growth factor B isoform Vegf-b186 precursor

      See identical proteins and their annotated locations for NP_035827.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (Vegf-b186).
      Source sequence(s)
      AK148188, CF804631, U43836
      Consensus CDS
      CCDS29516.1
      UniProtKB/Swiss-Prot
      P49766, Q3UG04, Q5D0B1, Q64290
      Related
      ENSMUSP00000025914.7, ENSMUST00000025914.7
      Conserved Domains (1) summary
      smart00141
      Location:45 → 126
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6959840..6965019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49766.2 GenPept UniProtKB/Swiss-Prot:P49766

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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