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    Ak3 adenylate kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 56248, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ak3provided by MGI
    Official Full Name
    adenylate kinase 3provided by MGI
    Primary source
    MGI:MGI:1860835
    See related
    Ensembl:ENSMUSG00000024782 AllianceGenome:MGI:1860835
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AK-3; Ak3l; Ak3l1; Akl3l
    Summary
    Predicted to enable adenylate kinase activity; identical protein binding activity; and nucleoside triphosphate adenylate kinase activity. Predicted to be involved in ADP biosynthetic process and nucleoside triphosphate metabolic process. Predicted to act upstream of or within phosphorylation. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human AK3 (adenylate kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 99.4), liver adult (RPKM 67.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ak3 in Genome Data Viewer
    Location:
    19 C1; 19 23.61 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (28968715..29026122, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (28995053..29048080, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene phytanoyl-CoA hydroxylase pseudogene Neighboring gene tektin 5 like Neighboring gene cell division cycle 37-like 1 Neighboring gene STARR-seq mESC enhancer starr_45875 Neighboring gene ribosomal protein L26 pseudogene Neighboring gene RIKEN cDNA 1700018L02 gene Neighboring gene STARR-positive B cell enhancer ABC_E1523 Neighboring gene STARR-seq mESC enhancer starr_45878 Neighboring gene predicted gene 9895 Neighboring gene STARR-positive B cell enhancer ABC_E3249 Neighboring gene RNA terminal phosphate cyclase-like 1 Neighboring gene microRNA 101b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix. Noma T, et al. Biochem J, 2001 Aug 15. PMID 11485571, Free PMC Article
    2. Biochemical diversity and evolution in the genus Mus. Bonhomme F, et al. Biochem Genet, 1984 Apr. PMID 6375655
    3. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, et al. Mol Cell, 2006 Aug. PMID 16916647
    4. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleobase-containing compound kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside triphosphate adenylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleoside triphosphate adenylate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, phosphate group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ADP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in AMP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in AMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in AMP phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GTP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ITP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UTP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside triphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GTP:AMP phosphotransferase AK3, mitochondrial
    Names
    adenylate kinase 3 alpha-like 1
    NP_001352000.1
    NP_067274.1
    XP_006527285.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365071.1 → NP_001352000.1  GTP:AMP phosphotransferase AK3, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113961
      UniProtKB/TrEMBL
      Q9D8W6
      Conserved Domains (1) summary
      pfam00406
      Location:12 → 189
      ADK; Adenylate kinase

    2. NM_021299.2 → NP_067274.1  GTP:AMP phosphotransferase AK3, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_067274.1

      Status: VALIDATED

      Source sequence(s)
      AK147060, AW457236
      Consensus CDS
      CCDS29730.1
      UniProtKB/Swiss-Prot
      Q3UDN7, Q8BGX5, Q9D7Z1, Q9DB57, Q9DBM5, Q9WTP7
      UniProtKB/TrEMBL
      Q9D8W6
      Related
      ENSMUSP00000025696.5, ENSMUST00000025696.5
      Conserved Domains (1) summary
      pfam00406
      Location:12 → 190
      ADK; Adenylate kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      28968715..29026122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527222.5 → XP_006527285.1  GTP:AMP phosphotransferase AK3, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam00406
      Location:12 → 189
      ADK; Adenylate kinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WTP7.3 GenPept UniProtKB/Swiss-Prot:Q9WTP7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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