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    Ppp2r5b protein phosphatase 2, regulatory subunit B', beta [ Mus musculus (house mouse) ]

    Gene ID: 225849, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ppp2r5bprovided by MGI
    Official Full Name
    protein phosphatase 2, regulatory subunit B', betaprovided by MGI
    Primary source
    MGI:MGI:2388480
    See related
    Ensembl:ENSMUSG00000024777 AllianceGenome:MGI:2388480
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B'beta
    Summary
    Predicted to enable protein phosphatase activator activity. Predicted to be involved in protein dephosphorylation. Predicted to act upstream of or within several processes, including positive regulation of cellular component organization; regulation of protein phosphorylation; and regulation of transcription, DNA-templated. Predicted to be located in cytoplasm. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including gut; nervous system; and sensory organ. Orthologous to human PPP2R5B (protein phosphatase 2 regulatory subunit B'beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 89.9), cerebellum adult (RPKM 51.2) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 A; 19 4.35 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6277795..6286294, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6227765..6236264, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene basic leucine zipper transcription factor, ATF-like 2 Neighboring gene membrane anchored junction protein Neighboring gene STARR-positive B cell enhancer ABC_E9990 Neighboring gene glycoprotein hormone alpha 2 Neighboring gene STARR-positive B cell enhancer ABC_E5681 Neighboring gene STARR-positive B cell enhancer ABC_E619 Neighboring gene autophagy related 2A Neighboring gene microRNA 194-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PPP2R5B, a regulatory subunit of PP2A, contributes to adipocyte insulin resistance. Beg M, et al. Mol Cell Endocrinol, 2016 Dec 5. PMID 27521959
    2. Clk2 and B56β mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt. Rodgers JT, et al. Mol Cell, 2011 Feb 18. PMID 21329884, Free PMC Article
    3. Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice. Martens E, et al. J Mol Biol, 2004 Feb 27. PMID 15095873
    4. The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Van Kanegan MJ, et al. Mol Cell Biol, 2009 Feb. PMID 19029245, Free PMC Article
    5. Novel genes differentially expressed in cortical regions during late neurogenesis. Mühlfriedel S, et al. Eur J Neurosci, 2007 Jul. PMID 17614941

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of G0 to G1 transition ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of neurotrophin TRK receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198168.3 → NP_937811.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

      See identical proteins and their annotated locations for NP_937811.1

      Status: VALIDATED

      Source sequence(s)
      AK171178
      Consensus CDS
      CCDS29499.1
      UniProtKB/Swiss-Prot
      Q3V3S8, Q6PD28, Q8R342
      Related
      ENSMUSP00000025695.10, ENSMUST00000025695.10
      Conserved Domains (1) summary
      pfam01603
      Location:69 → 467
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6277795..6286294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161520.1 → XP_036017413.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1

      UniProtKB/Swiss-Prot
      Q3V3S8, Q6PD28, Q8R342
      Conserved Domains (1) summary
      pfam01603
      Location:69 → 467
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    2. XM_030250869.1 → XP_030106729.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X2

      Conserved Domains (1) summary
      pfam01603
      Location:1 → 381
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PD28.1 GenPept UniProtKB/Swiss-Prot:Q6PD28

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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