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    Keg1 kidney expressed gene 1 [ Mus musculus (house mouse) ]

    Gene ID: 64697, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Keg1provided by MGI
    Official Full Name
    kidney expressed gene 1provided by MGI
    Primary source
    MGI:MGI:1928492
    See related
    Ensembl:ENSMUSG00000024694 AllianceGenome:MGI:1928492
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GS4059; 0610008P16Rik
    Summary
    Predicted to enable glycine N-acyltransferase activity and glycine N-benzoyltransferase activity. Predicted to be involved in benzoyl-CoA metabolic process and glycine metabolic process. Located in mitochondrion. Is expressed in several structures, including genitourinary system and liver. Orthologous to human GLYAT (glycine-N-acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward kidney adult (RPKM 563.1) See more
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    Genomic context

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    See Keg1 in Genome Data Viewer
    Location:
    19 A; 19 8.73 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (12673154..12697266)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (12695790..12719902)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 5 subfamily B member 94 Neighboring gene olfactory receptor family 5 subfamily B member 95 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45598 Neighboring gene predicted readthrough transcript (NMD candidate), 44505 Neighboring gene ciliary neurotrophic factor Neighboring gene zinc finger protein 91 Neighboring gene STARR-positive B cell enhancer ABC_E11024 Neighboring gene STARR-positive B cell enhancer ABC_E4268 Neighboring gene leupaxin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. HP33: hepatocellular carcinoma-enriched 33-kDa protein with similarity to mitochondrial N-acyltransferase but localized in a microtubule-dependent manner at the centrosome. Nakadai T, et al. J Cell Sci, 1999 May. PMID 10194414
    2. Structure of rat gamma-tubulin and its binding to HP33. Nakadai T, et al. DNA Res, 1999 Jun 30. PMID 10470852
    3. Isolation of genes identified in mouse renal proximal tubule by comparing different gene expression profiles. Takenaka M, et al. Kidney Int, 1998 Mar. PMID 9507200
    4. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, et al. Mol Cell, 2006 Aug. PMID 16916647
    5. Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Tang F, et al. PLoS One, 2011. PMID 21731673, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycine N-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glycine N-acyltransferase-like protein Keg1
    Names
    Acyl-CoA:glycine N-acyltransferase protein Keg1
    kidney-expressed gene 1 protein
    NP_083826.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029550.4 → NP_083826.1  glycine N-acyltransferase-like protein Keg1

      See identical proteins and their annotated locations for NP_083826.1

      Status: VALIDATED

      Source sequence(s)
      AC150901, AI099383, AK165515
      Consensus CDS
      CCDS29636.1
      UniProtKB/Swiss-Prot
      Q9DCY0
      Related
      ENSMUSP00000025598.4, ENSMUST00000025598.10
      Conserved Domains (2) summary
      pfam08444
      Location:206 → 294
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:10 → 205
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      12673154..12697266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCY0.1 GenPept UniProtKB/Swiss-Prot:Q9DCY0

    Gene LinkOut

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