Fth1 ferritin heavy polypeptide 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fth1provided by MGI
Official Full Name: ferritin heavy polypeptide 1provided by MGI
Primary source: MGI:MGI:95588
See related: Ensembl:ENSMUSG00000024661 AllianceGenome:MGI:95588
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FHC; Fth; HFt; MFH
Summary: Enables iron ion binding activity. Acts upstream of or within iron ion transport. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hemochromatosis type 5. Orthologous to human FTH1 (ferritin heavy chain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum adult (RPKM 10006.4), adrenal adult (RPKM 4705.3) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 6.23 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (9957964..9962475)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (9980600..9985111)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adipose knockout of H-ferritin improves energy metabolism in mice.
Title: Adipose knockout of H-ferritin improves energy metabolism in mice.
H-Ferritin Produced by Myeloid Cells Is Released to the Circulation and Plays a Major Role in Liver Iron Distribution during Infection.
Title: H-Ferritin Produced by Myeloid Cells Is Released to the Circulation and Plays a Major Role in Liver Iron Distribution during Infection.
A Shortage of FTH Induces ROS and Sensitizes RAS-Proficient Neuroblastoma N2A Cells to Ferroptosis.
Title: A Shortage of FTH Induces ROS and Sensitizes RAS-Proficient Neuroblastoma N2A Cells to Ferroptosis.
Impaired Postnatal Myelination in a Conditional Knockout Mouse for the Ferritin Heavy Chain in Oligodendroglial Cells.
Title: Impaired Postnatal Myelination in a Conditional Knockout Mouse for the Ferritin Heavy Chain in Oligodendroglial Cells.
H-Ferritin is essential for macrophages' capacity to store or detoxify exogenously added iron.
Title: H-Ferritin is essential for macrophages' capacity to store or detoxify exogenously added iron.
Iron and Ferritin Modulate MHC Class I Expression and NK Cell Recognition.
Title: Iron and Ferritin Modulate MHC Class I Expression and NK Cell Recognition.
Deleting Fth in vitro significantly reduce schwann cell proliferation, maturation, and the myelination of DRG axons. This was accompanied by an important reduction in iron incorporation and storage.
Title: Iron Metabolism in the Peripheral Nervous System: The Role of DMT1, Ferritin, and Transferrin Receptor in Schwann Cell Maturation and Myelination.
Fth deletion was associated with a profound atrophy of white and brown adipose tissue as well as with collapse of energy expenditure and thermogenesis.
Title: Ferritin regulates organismal energy balance and thermogenesis.
We provide novel findings that identify the NF-kappaB pathway as a main target of circulating ferritin to establish a restrained response to infection. It elucidate a crucial immunomodulatory function for circulating ferritin that challenges the traditional view of this protein as a mere marker of body iron stores. These findings will stimulate investigations to the adaptive nature of this protein in diverse clinical s...
Title: Ferritin Light Chain Confers Protection Against Sepsis-Induced Inflammation and Organ Injury.
Study using murine model of pulmonary tuberculosis identified unsuspected mechanisms whereby Mycobacterium tuberculosis (Mtb) exploits the metabolic vulnerability of dysregulated iron metabolism. Data suggest that ferritin-H (FtH)-mediated iron dysregulation interrupts metabolic pathways in the lungs of infected mice to shift immune cell fate to excessive inflammation, extensive dissemination of Mtb, and lethal pathology.
Title: Ferritin H Deficiency in Myeloid Compartments Dysregulates Host Energy Metabolism and Increases Susceptibility to Mycobacterium tuberculosis Infection.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124242 (e-PCR)
- UniSTS:161064

RH125317 (e-PCR)
- UniSTS:162139

RH94403 (e-PCR)
- UniSTS:119651

Fth1 (e-PCR), detects polymorphism
- UniSTS:532423

RH127322 (e-PCR)
- UniSTS:210632

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ferric iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferrous iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferrous iron binding	ISO Inferred from Sequence Orthology more info
enables ferroxidase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IDA Inferred from Direct Assay more info	PubMed
enables iron ion sequestering activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular iron ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular iron ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular sequestering of iron ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within iron ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in autolysosome	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endocytic vesicle lumen	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: ferritin heavy chain

Names: H-ferritin; ferritin H subunit; ferritin heavy chain 1

NP_034369.1

EC 1.16.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010239.2 → NP_034369.1 ferritin heavy chain

See identical proteins and their annotated locations for NP_034369.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the protein.

Source sequence(s)

AC134437, AK147082

Consensus CDS

CCDS29567.1

UniProtKB/Swiss-Prot

P09528, Q3UI44

Related

ENSMUSP00000025563.7, ENSMUST00000025563.8

Conserved Domains (1) summary

cd01056
Location:14 → 174

Euk_Ferritin; eukaryotic ferritins

RNA

NR_073181.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an extended 5' splice structure, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC134437, AK152702