Apom apolipoprotein M [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Apomprovided by MGI
Official Full Name: apolipoprotein Mprovided by MGI
Primary source: MGI:MGI:1930124
See related: Ensembl:ENSMUSG00000024391 AllianceGenome:MGI:1930124
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: G3a; NG20; 1190010O19Rik
Summary: Enables antioxidant activity. Involved in several processes, including cholesterol efflux; high-density lipoprotein particle clearance; and plasma lipoprotein particle organization. Acts upstream of or within lipoprotein metabolic process and reverse cholesterol transport. Located in extracellular region. Part of discoidal high-density lipoprotein particle. Is expressed in several structures, including gut; liver; male reproductive gland or organ; and urinary system. Human ortholog(s) of this gene implicated in coronary artery disease; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human APOM (apolipoprotein M). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 336.8), liver E18 (RPKM 311.5) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 18.59 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (35347973..35350777, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (35128997..35131801, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Apolipoprotein M bound sphingosine 1-phosphate suppresses NETosis through activating S1P1 and S1P4.
Title: Apolipoprotein M bound sphingosine 1-phosphate suppresses NETosis through activating S1P1 and S1P4.
Apolipoprotein M/sphingosine 1-phosphate protects against diabetic nephropathy.
Title: Apolipoprotein M/sphingosine 1-phosphate protects against diabetic nephropathy.
Hepatic FoxOs link insulin signaling with plasma lipoprotein metabolism through an apolipoprotein M/sphingosine-1-phosphate pathway.
Title: Hepatic FoxOs link insulin signaling with plasma lipoprotein metabolism through an apolipoprotein M/sphingosine-1-phosphate pathway.
Apolipoprotein M promotes cholesterol uptake and efflux from mouse macrophages.
Title: Apolipoprotein M promotes cholesterol uptake and efflux from mouse macrophages.
Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein.
Title: Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein.
Endothelial Spns2 and ApoM Regulation of Vascular Tone and Hypertension Via Sphingosine-1-Phosphate.
Title: Endothelial Spns2 and ApoM Regulation of Vascular Tone and Hypertension Via Sphingosine-1-Phosphate.
Comprehensive lipidomics in apoM(-/-) mice reveals an overall state of metabolic distress and attenuated hepatic lipid secretion into the circulation.
Title: Comprehensive lipidomics in apoM(-/-) mice reveals an overall state of metabolic distress and attenuated hepatic lipid secretion into the circulation.
Increased expression levels of inflammatory cytokines and adhesion molecules in lipopolysaccharideinduced acute inflammatory apoM/ mice.
Title: Increased expression levels of inflammatory cytokines and adhesion molecules in lipopolysaccharide‑induced acute inflammatory apoM‑/‑ mice.
Insulin Resistance in Apolipoprotein M Knockout Mice is Mediated by the Protein Kinase Akt Signaling Pathway.
Title: Insulin Resistance in Apolipoprotein M Knockout Mice is Mediated by the Protein Kinase Akt Signaling Pathway.
Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair.
Title: Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Apom (e-PCR), detects polymorphism
- UniSTS:506682

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antioxidant activity	IDA Inferred from Direct Assay more info	PubMed
enables antioxidant activity	ISO Inferred from Sequence Orthology more info
enables lipid transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipid transporter activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cholesterol efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol efflux	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in high-density lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in high-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipoprotein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of plasma lipoprotein oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of plasma lipoprotein oxidation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reverse cholesterol transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of discoidal high-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed
part_of discoidal high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of high-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of spherical high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apolipoprotein M

Names: apo-M

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.