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    Nudt3 nudix hydrolase 3 [ Mus musculus (house mouse) ]

    Gene ID: 56409, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Nudt3provided by MGI
    Official Full Name
    nudix hydrolase 3provided by MGI
    Primary source
    MGI:MGI:1928484
    See related
    Ensembl:ENSMUSG00000024213 AllianceGenome:MGI:1928484
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dipp; Dipp1; 1110011B09Rik
    Summary
    Predicted to enable magnesium ion binding activity and pyrophosphatase activity. Predicted to be involved in RNA decapping and organophosphate catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to human NUDT3 (nudix hydrolase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 71.3), adrenal adult (RPKM 66.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A3.3; 17 14.59 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (27798356..27842426, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (27579382..27623452, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42162 Neighboring gene high mobility group AT-hook 1 Neighboring gene small integral membrane protein 29 Neighboring gene STARR-positive B cell enhancer ABC_E8662 Neighboring gene STARR-seq mESC enhancer starr_42166 Neighboring gene STARR-seq mESC enhancer starr_42169 Neighboring gene ribosomal protein S10 Neighboring gene predicted gene 15420 Neighboring gene protein kinase C and casein kinase substrate in neurons 1 Neighboring gene STARR-seq mESC enhancer starr_42171

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ectopic expression of murine diphosphoinositol polyphosphate phosphohydrolase 1 attenuates signaling through the ERK1/2 pathway. Chu C, et al. Cell Signal, 2004 Sep. PMID 15212765
    2. The Obesity-Linked Gene Nudt3 Drosophila Homolog Aps Is Associated With Insulin Signaling. Williams MJ, et al. Mol Endocrinol, 2015 Sep. PMID 26168034, Free PMC Article
    3. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables bis(5'-adenosyl)-hexaphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bis(5'-adenosyl)-pentaphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diphosphoinositol-polyphosphate diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diphosphoinositol-polyphosphate diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endopolyphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopolyphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol diphosphate pentakisphosphate diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol diphosphate tetrakisphosphate diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA decapping IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in RNA decapping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenosine 5'-(hexahydrogen pentaphosphate) catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in diadenosine hexaphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in diadenosine hexaphosphate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in diadenosine pentaphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in diphosphoinositol polyphosphate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in diphosphoinositol polyphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    diphosphoinositol polyphosphate phosphohydrolase 1
    Names
    DIPP-1
    ap6A hydrolase
    diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1
    diadenosine hexaphosphate hydrolase
    endopolyphosphatase
    m7GpppN-mRNA hydrolase
    m7GpppX diphosphatase
    nudix (nucleoside diphosphate linked moiety X)-type motif 3
    nudix (nucleotide diphosphate linked moiety X)-type motif 3
    NP_001277975.1
    NP_062811.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291046.1 → NP_001277975.1  diphosphoinositol polyphosphate phosphohydrolase 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' terminal exon compared to variant 1. The resulting protein (isoform 1) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC127341, AC131800, BU919402
      Consensus CDS
      CCDS70776.1
      UniProtKB/TrEMBL
      A0A338P6T6, B2KF67
      Related
      ENSMUSP00000110536.2, ENSMUST00000114886.8
      Conserved Domains (1) summary
      cd04666
      Location:4 → 105
      Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

    2. NM_019837.2 → NP_062811.1  diphosphoinositol polyphosphate phosphohydrolase 1 isoform 1

      See identical proteins and their annotated locations for NP_062811.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AC127341, AC131800
      Consensus CDS
      CCDS28566.1
      UniProtKB/Swiss-Prot
      B2KF68, Q6PG02, Q8BV71, Q9JI46
      UniProtKB/TrEMBL
      I1E4X7
      Related
      ENSMUSP00000025050.6, ENSMUST00000025050.13
      Conserved Domains (1) summary
      cd04666
      Location:19 → 134
      Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      27798356..27842426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JI46.1 GenPept UniProtKB/Swiss-Prot:Q9JI46

    Gene LinkOut

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