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    Themis3 thymocyte selection associated family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 74556, updated on 27-Feb-2024

    Summary

    Official Symbol
    Themis3provided by MGI
    Official Full Name
    thymocyte selection associated family member 3provided by MGI
    Primary source
    MGI:MGI:1921806
    See related
    Ensembl:ENSMUSG00000024105 AllianceGenome:MGI:1921806
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9130404H23Rik
    Summary
    Predicted to be involved in T cell receptor signaling pathway. Predicted to be active in cytoplasm and nucleus. Orthologous to human THEMIS3P (thymocyte selection associated family member 3, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 23.6), small intestine adult (RPKM 11.9) and 2 other tissues See more
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    Genomic context

    See Themis3 in Genome Data Viewer
    Location:
    17 E1.1; 17 37.88 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (66861519..66901642, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (66554524..66594647, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43061 Neighboring gene microtubule crosslinking factor 1 Neighboring gene STARR-seq mESC enhancer starr_43062 Neighboring gene STARR-seq mESC enhancer starr_43065 Neighboring gene STARR-seq mESC enhancer starr_43067 Neighboring gene STARR-seq mESC enhancer starr_43070 Neighboring gene VISTA enhancer mm1499 Neighboring gene STARR-seq mESC enhancer starr_43072 Neighboring gene predicted gene 4705 Neighboring gene STARR-seq mESC enhancer starr_43077 Neighboring gene STARR-seq mESC enhancer starr_43079 Neighboring gene predicted gene, 41608 Neighboring gene RAB12, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_43080 Neighboring gene predicted gene, 46576 Neighboring gene VISTA enhancer mm1745 Neighboring gene RIKEN cDNA 1700016K05 gene Neighboring gene protein tyrosine phosphatase receptor type M

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein THEMIS3
    Names
    thymocyte-expressed molecule involved in selection protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028998.2NP_083274.1  protein THEMIS3

      See identical proteins and their annotated locations for NP_083274.1

      Status: VALIDATED

      Source sequence(s)
      AC122445, CT010496
      Consensus CDS
      CCDS50170.1
      UniProtKB/Swiss-Prot
      Q9CU24
      Related
      ENSMUSP00000024914.3, ENSMUST00000024914.4
      Conserved Domains (1) summary
      pfam12736
      Location:17262
      CABIT; Cell-cycle sustaining, positive selection,

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      66861519..66901642 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)